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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#551

Post by lordnacho »

dragonwriter wrote: post #536
davidhowlett wrote: post #529

Earlier quoted context omitted.

I believe the 1918 flu also had the unusual property of killing people in their 20s at a higher rate than the middle aged and old. https://wwwnc.cdc.gov/eid/article/12/1/05-0979-f3

For much of 1918, a lot of people in their 20s getting the flu were also experiencing trench warfare, which can't be an optimal situation, both in terms of immediate self-care and co-occurring health conditions.

I guess you should see that it was just men in their 20s in the stats then?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#552

Post by divbzero »

aphextron wrote: post #527
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

>AMA? Have you experienced any side effects, even mild like injection pain or fatigue? I'm in the Moderna study and feel pretty disappointed that I may have gotten the placebo.

… or you might have been lucky with getting minimal side effects.

Double blinded placebo controls are critical to clinical trials so you shouldn’t be disappointed one way or the other. Even if you are in the control group you’ll have the opportunity to get the vaccine after you’ve helped prove its efficacy and safety.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#553

Post by vmurthy »

jobigoud wrote: post #517
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

Do you get to know, at the end of trial, in which group you were?

Not OP but from the reports I have read, people who have been given placebos will be informed if the actual vaccine is found be really effective. This is for ethical concerns (in the sense that it would be unethical to not vaccinate people who have got a placebo if the real vaccine is really effective)

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#554

Post by pageandrew »

Dig1t wrote: post #520
Bobblebobble wrote: post #303

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

ChAd to the rescue!

Virgin SARS-CoV- 2 vs Chad ChAdOx1

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#555

Post by neuronic »

Animats wrote: post #499

This is only one of 11 vaccines now in phase III efficacy tests.[1] Six vaccines already have "partial approval", but those are the ones in Russia and China, which may or may not be working, and the governments decided to try anyway. All of those provoke an immune response. Whether it's enough of the right immune response is found out in phase III testing. Something is probably going to work. The big question is how…

Not happening, recent polls suggest that in Germany, 55% percent of the population is willing to get the vaccine.

That isn't enough for herd immunity (at around 60%) and real vaccination rate will be even lower.

There is also no chance in hell that Germans will allow a government-mandated vaccine. It's unconstitutional and there is heavy opposition to government-mandated anything throughout all of society.

So we will be stuck with this virus. But you're free to get the vaccine yourself for your own protection.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#557

Post by neuronic »

maxehmookau wrote: post #359
xwdv wrote: post #357

Earlier quoted context omitted.

How do you prove to people you are in a vaccine trial, do you have a card?

I have a "red alert" card so if I'm found unconscious a paramedic knows to contact the study team to find out if I'm in the control arm or I've had the active vaccine so they can rule out if it's important to why I was found unconscious! But it is just a piece of paper that the team printed out, and I think I lost it.

Paramedics won't go through your wallet anyways.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#558

Post by castis »

alfiedotwtf wrote: post #556

Anyone notice vaccine good news always drops when the Dow drops about 2%? Every time

My understanding is that because stimulus packages are good for the stock market. When hopes are up about a vaccine, the possibility of a stimulus drops, hence the market comes down.

I've only been following the market for about a year, but its a weird thing.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#559

Post by StavrosK »

jedberg wrote: post #455
scrumbledober wrote: post #454

Earlier quoted context omitted.

yes because people in the control group would get sick. Once a certain amount of people get sick they see how many of those people were in control vs vaccine group. In your hypothetical, 100% of the sick people would be from the control group.

Ah this is true. Thanks. I was thinking that some number of vaccinated people had to get sick.

The only issue is that it'd take twice as long to conclude the trial, since you thought that you had X vulnerable people but you only had X/2.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#560

Post by Someone »

cookingrobot wrote: post #402
EpicEng wrote: post #391

Earlier quoted context omitted.

>But for this disease that's particularly bad because... Doesn't change the fact that, when you're developing a new drug, you want to test it in a way which will cause the least harm. You don't begin trials with those most at risk for obvious reasons. The primary goal of this phase it to asses the safety of the vaccine candidate. I'm also unaware of any disease that isn't more threatening to people in relatively poor…

You say it’s “obvious” but it’s the opposite of my intuition. Can you explain the logic a bit more? I would have thought you’d give a risky new drug to the least healthy, most likely to die without it population, to raise the chance of survival from low to unknown.

In addition to what others said, if you know or suspect the procedure is extremely risky, and no other good options exist, you _do_ start with the least healthy.

As an example, the patient who got the first heart transplant:

“As a result of heart attacks in 1965, approximately only one third of his heart was still functioning. In late October, he went into a diabetic coma, but regained consciousness. […] He was also suffering from kidney and liver failure.”

(https://en.wikipedia.org/wiki/Louis_Washkansky)

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