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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#441

Post by hobby-coder-guy »

threeseed wrote: post #64
calvinv wrote: post #32

Earlier quoted context omitted.

if we're back to normalish by spring next year I think that would be a great outcome, if the messaging to the public would be, buckle down until then I think lockdown complaince could go up

It likely won't be available to everyone in the US until Autumn timeframe. Perhaps even later if the vaccine needs repeated dosages over time. Priority will be health care workers, essential retail, vulnerable etc. By then it will kill at least a million people at the current trajectory. So US needs to start acting more aggressively now.

What season do you think we are in?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#442

Post by ksk »

cwhiz wrote: post #428
keyme wrote: post #423

Earlier quoted context omitted.

Placebo can have an effect on side effects.

Are they testing for side effects in all three stages? I thought the first two trials were for safety and the third was for efficacy. Is that incorrect?

Data on adverse reactions is captured by the CDC/FDA/HHS throughout the lifecycle of the vaccine, from all the phases of clinical trials to its use in the general population. Its required by law.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#443

Post by C1sc0cat »

logicchains wrote: post #262
C1sc0cat wrote: post #153

Earlier quoted context omitted.

Some of the longer term effects are scary though - I suspect that younger people might not be so blasé about chronic illness. At minimum younger people who have had covid are looking at a lot more regular check-ups for the rest of there life.

> Some of the longer term effects are scary though - I suspect that younger people might not be so blasé about chronic illness. There's not a single peer-reviewed study showing a significantly higher frequency of long-term adverse effects in healthy individuals compared to other respiratory illnesses.

There's initial results that indicate that its likely - you wont get hard data for another decade plus - but take it from me you don't want to get CKD or similar organ damage.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#444

Post by kortilla »

xnyan wrote: post #401
SamBam wrote: post #377

Earlier quoted context omitted.

To add some context to this, medical trials generally only compensate time (at a low hourly rate) and expenses, occasionally increased slightly to compensate for hardship. They deliberately do not pay large amounts, because the money is not supposed to overly-incentivize the participation, to avoid ethical issues where someone might choose to participate in something very unsafe only because the reward seems so large…

I did various medial trials in college for money and have mixed feelings about this. When sitting in the various waiting rooms, it was very clear that was only one kind of person that did "open" (not targeting people with a disorder but rather recruiting healthy volunteers) medical trials: the poor. I got to know lots of of people well (we were frequent flyers in the medical trial world), and our common characteristi…

The problem is increasing the reward makes the people “who need the money” much more willing to engage in trials with much worse possible side effects. As long as the pay isn’t life altering money for anyone, nobody will volunteer to do something with a high probability of life altering side effects.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#445

Post by FuckButtons »

fcsp wrote: post #349
Bobblebobble wrote: post #303

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

Considering all the excluded groups on the trial (page 3, kids, 55+, obese, weak immune system, a lot more), it's a lot of exclusions, how does one get from results on a study like this to declaring the vaccine safe for general use?

There isn’t just one trial - there are other safety trials being run in vulnerable groups.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#446

Post by ksk »

xwdv wrote: post #348
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

What if something goes horribly wrong and the vaccine trial causes unwanted side effects? Why risk it, what are they paying you?

By the time human trials commence, we're as sure as we can be that it's safe. Due to how the system is set up at the governmental level, whenever any participant in the trial experiences adverse reactions, the trial is halted, until an explanation can be given. It's a serious concern that can and does lead to products not being approved by the FDA. Not being approved = loss of tens or sometimes hundreds of millions of dollars. People take this stuff very very very seriously :)

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#447

Post by pvg »

fallingfrog wrote: post #340
dang wrote: post #180

Earlier quoted context omitted.

Would you please stop posting flamebait to HN and not use the site primarily for ideological battle? We ban accounts that do those things and have already had to ask you a few times. https://news.ycombinator.com/newsguidelines.html

I’m genuinely surprised.. Does this comment really read as flamebait? The article is about vaccines. A vaccine has to be administered to everyone to work. But I’m very skeptical that it’s actually going to happen given the way our medical system works here. So, I predict that there’s a good chance we won’t get herd immunity. I just don’t see how that’s flamebait. It’s more, known facts and extrapolation.

known facts

You can look up the moderator commentary on 'facts' and flamebait (tldr is, you can flamebait with facts) but these aren't even facts - free vaccine has been the stated official plan in the US for months.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#448

Post by kortilla »

guptaneil wrote: post #399
vorpalhex wrote: post #363

Earlier quoted context omitted.

If your statement was true, Chicago and California would be bastions of government efficiency and capability. Instead we see both Republican and Democratic cities do terribly on most measures, and those cities that generally prosper have very little to do with who is in control other than it not being a single party and they have the right conditions for job growth. School funding happens at the state level too, not…

It's funny you bring that up, because my comment originally even included a bit about how a lot of our current problems can be traced back to Reagan's presidency. He was previously governor of California. Guess when California stopped offering free higher education? Chicago is in Illinois, which has had a lot of flip-flopping between red and blue governors and has an infamous history of governors going to jail for co…

> He was previously governor of California. Guess when California stopped offering free higher education?

And why hasn’t California added free public education or expanded housing in the last 20-30 years then?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#449

Post by chimprich »

marketingPro wrote: post #101
henearkr wrote: post #65

Earlier quoted context omitted.

The statistics are in the making, and researchers discover more illness mechanisms each day. As I said, we are in the presence of a huge risk and there is no "reassuring numbers" anywhere to counterbalance that. As one reference on the risks I'm speaking of, here is an article about the action of the virus on the nerve cells: https://www.scientificamerican.com/article/what-we-know-so-f... By the way, between "relying…

Suicide, abuse/trauma, avoided medical treatments, drug and alcohol addictions, and depression have all been seen to increase since we first had lockdowns. There is no safe solution, it's a decision between protecting the 0.5% old, obese, and sick or the 99.5%

> Suicide, abuse/trauma, [...], drug and alcohol addictions, and depression have all been seen to increase since we first had lockdowns.

Correlation versus causation.

We're in the middle of a major health emergency. Why are you attributing those to the effects of lockdowns, rather than the effects of the pandemic? You don't think that the risk to personal health of a potentially lethal virus, seeing older friends and relatives dying, and worrying about the risk of health systems collapsing are causing any of the above?

In March, someone I know in Italy passed on the virus to his grandfather, who died at home. All the ambulances in the area were tied up for hours. You can imagine the effect on his mental health. I doubt the impact was comparable to the effects of intermittent lockdowns.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#450

Post by rtx »

geuis wrote: post #304
sanketskasar wrote: post #42

Earlier quoted context omitted.

It is the same. But you cannot expect a vaccine to work similarly in people of two different regions having major differences in their diet, climate and lifestyles. That's why many vaccine candidates are being tested in multiple countries( read potential markets). Also, I think the UK has preferential rights at least on the initial yield of the vaccine.

I don’t think you understand how the biology of vaccines work.

Vaccines do have different effect on different people.
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