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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

371–380 of 712 posts

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#371

Earlier quoted context omitted.

> (like we have for literally every single fatal illness) Smallpox. And if you consider within the borders of a given country, a dozen others (polio, measles, mumps, rubella, chickenpox).

None of those are a common type of Flu, which we've never been able to cure, though.

Covid-19 isn't a "common type of flu" either. The diseases I mentioned were certainly widespread and endemic. And they're all different types of virus.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#372
post #354
post #349

Earlier quoted context omitted.

Considering all the excluded groups on the trial (page 3, kids, 55+, obese, weak immune system, a lot more), it's a lot of exclusions, how does one get from results on a study like this to declaring the vaccine safe for general use?

Extrapolation. Is there a scientific rationale as to why the vaccine would NOT be safe and effective in a new population? If not, approve it for that population. If there is rationale why it wouldn’t be, ask for more data.

Why would the reasons used to exclude those cohorts in the first place not be used to determine the vaccine is unsafe for said cohorts?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#373
post #286

Earlier quoted context omitted.

> What is the alternative? We create a government agency that specializes in manufacturing and distributing pharma products? Yes. Why don't you think that would work?

Because the government hasn't been able to do anything right for 270 years, why do you think they're suddenly gonna wake up a figure out mass manufacturing? We can't educate our kids at an acceptable level without billions of dollars being donated on top of all the tax collected, we can't figure out how to make medicare work responsibly despite literally being able to control costs, what do you think makes drug manuf…

> Because the government hasn't been able to do anything right for 270 years, why do you think they're suddenly gonna wake up a figure out mass manufacturing?

worked just fine for penicillin during world war 2

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#375
post #349

Earlier quoted context omitted.

Considering all the excluded groups on the trial (page 3, kids, 55+, obese, weak immune system, a lot more), it's a lot of exclusions, how does one get from results on a study like this to declaring the vaccine safe for general use?

Maybe a stupid question, but do we need to vaccinate everyone? I remember reading that heard immunity is 70% or something - so could we get away with leaving the people out that it wasn’t tested on?

https://en.wikipedia.org/wiki/Herd_immunity#Mechanics

It varies by disease. Can anyone really say what the % is/would be for covid-19?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#376
post #349

Earlier quoted context omitted.

Considering all the excluded groups on the trial (page 3, kids, 55+, obese, weak immune system, a lot more), it's a lot of exclusions, how does one get from results on a study like this to declaring the vaccine safe for general use?

Maybe a stupid question, but do we need to vaccinate everyone? I remember reading that heard immunity is 70% or something - so could we get away with leaving the people out that it wasn’t tested on?

It's not a stupid question, and I've heard that some vaccines are aiming to be approved only for adults at first. This would make sense not only because, as you say, you can start to approach herd immunity without vaccinating everyone, but also because children are weaker spreaders.

Obviously "herd immunity" is more of a gradient than a cut-off, and it's much easier to approach it if we can vaccinate everyone, but we can definitely speed up the process (including the months-long process to even get the vaccines to everyone) if we can start vaccinating some people early.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#377
post #366

Earlier quoted context omitted.

Are you given any monetary compensation or compensation at all for joining the trial?

From TFPDF: >You will be compensated for your time, the inconvenience of having blood tests and procedures, and your travel expenses. The total amount compensated will be approximately £235 - £625 depending on the exact number of visits and whether any repeat or additional visits are necessary.

To add some context to this, medical trials generally only compensate time (at a low hourly rate) and expenses, occasionally increased slightly to compensate for hardship.

They deliberately do not pay large amounts, because the money is not supposed to overly-incentivize the participation, to avoid ethical issues where someone might choose to participate in something very unsafe only because the reward seems so large.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#378
post #349

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

Considering all the excluded groups on the trial (page 3, kids, 55+, obese, weak immune system, a lot more), it's a lot of exclusions, how does one get from results on a study like this to declaring the vaccine safe for general use?

This phase I/II study's primary objective was to learn about the safety of the vaccine, and about whether it causes an immune response. I'm no expert, but I expect the phase III trials in the US and India will include a broader population.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#379

Earlier quoted context omitted.

I guess that's the thing; the gov't is the one who made the decision to bring kids back fulltime, how incompetent do you have to be to not know there'd be a bump in testing demands? Re: Waterloo region, I work at Google Waterloo, so although I don't live in KW (I'm in rural Flamborough) most of my coworkers do. I had one who showed up at 7am to get a test, lineups were around several blocks and they shut the whole th…

Oh yeah, definitely. Can't help thinking of how much better things would likely be if we'd had a Horwath administration through this crisis. :(

I like Horwath but I think her admin would have faced insurmountable ideological opposition, the same way Rae did. And then the whole COVID response would have been framed in those terms, as a right-left politicization like it is in the US. At least now, with a right wing government administrating the COVID response, only the far lunatic right (cough Randy Hillier cough) has politicized it. For conservatives, it's "their guy" delivering the tough medicine, and they just blame Trudeau for anything they don't like, even things the feds have nothing to do with. While it hasn't been great the management of this situation is not _nearly_ as bad as it could be. Just look at Jason Kenney's gov't.
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