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How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

pubmed.ncbi.nlm.nih.gov

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Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#101

Post by xkcd-sucks »

phobosanomaly wrote: post #33
kevinmgranger wrote: post #24

Earlier quoted context omitted.

Megadosing B12 (if your diet isn't already sufficient in it, which is common amongst certain vegan diets) is still a good idea, no? I recognize this might be the only exception.

I don't see any evidence that it's a bad idea, but from poking around I get the feeling that there is still a lot about it that we don't know. For instance, it may be monkeying around with blood flow to the kidneys somehow. "Among patients with diabetic nephropathy, high doses of B vitamins compared with placebo resulted in a greater decrease in GFR and an increase in vascular events." https://jamanetwork.com/journal…

I mean yeah if you're doing heroic doses of something that you pee out, then your kidneys will be stressed out

... if you're doing heroic doses of something you can't pee out then it's a bit worse

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#102

Post by AQuantized »

vecter wrote: post #32

I had a mini-episode of this earlier this year. Reposting as a warning for people: I had mild Vitamin D deficiency which was diagnosed by a doctor many years ago. I was given Vitamin D supplements, which I stocked up on more than usual recently due to my staying in all day due to WFH and not getting any sunlight. I used to take 50mcg of D3 1-2x a week and I upped that (without consulting a doctor) to 5x a week. Withi…

It seems very unlikely this was Vitamin D related. 1400iu daily is a relatively low amount. Further, Vitamin D is fat soluble, so the amount you take on a given day will have little effect on your overall Vitamin D status, as it builds up in fat over time. If you were really at the point where you had hypervitaminosis D it would have taken a long time to reduce to normal levels.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#104

Post by Wolfenstein98k »

e9 wrote: post #82
TedDoesntTalk wrote: post #62

Earlier quoted context omitted.

Why would you need so much?

If you do strenuous workouts frequently then this helps you recover faster and workout longer. If you are just couch potato then it’s actually detrimental and you can develop all sorts of problems including peripheral neuropathy.

Strenuous workouts don't cause chronic deficiency and don't eliminate chronic overdosing.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#105

Post by Wolfenstein98k »

vecter wrote: post #32

I had a mini-episode of this earlier this year. Reposting as a warning for people: I had mild Vitamin D deficiency which was diagnosed by a doctor many years ago. I was given Vitamin D supplements, which I stocked up on more than usual recently due to my staying in all day due to WFH and not getting any sunlight. I used to take 50mcg of D3 1-2x a week and I upped that (without consulting a doctor) to 5x a week. Withi…

There is no data anywhere showing that 2000IU causes toxicity or harm in anyone.

Could it have been anything else?

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#106

Post by scns »

sva_ wrote: post #47
kevinmgranger wrote: post #24

Earlier quoted context omitted.

Megadosing B12 (if your diet isn't already sufficient in it, which is common amongst certain vegan diets) is still a good idea, no? I recognize this might be the only exception.

The trouble with Vitamin D is afaik, as with some other vitamins, that it is fat-soluble rather than water-soluble. So the excess of the Vitamin won't be flushed out through the urine - but rather accumulates in the fat. At some point this accumulation may lead to toxicity ("Hypervitaminosis D" [1]). Personally, I dose 4000-5000 IU D3+K2 in the darker seasons and that has been working well for me. Vitamin B12 is wate…

You are spot on: https://en.wikipedia.org/wiki/Hypervitaminosis

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#107

Post by koliber »

orblivion wrote: post #42

I initially thought there was a mistake referring to "UI" instead of "IU", but it looks like it's a European thing. The authors' names look Italian. I guess it got lost in translation.

IU is a neat unit. Vitamins can often come in multiple forms, and each will have a different bioavailability. IU normalizes that. When you measure vitamins in mcg the dose may differ from one form to another.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#108

Post by raverbashing »

PragmaticPulp wrote: post #5

The title doesn’t match the abstract. This isn’t a study of the tolerable upper limit of Vitamin D intake. It’s a case report of a single individual who was taking astronomical doses of Vitamin D with disastrous consequences. It’s certainly possible to take too much vitamin D without coming anywhere near the silly doses this person was consuming. Anyone taking aggressive vitamin D doses should invest in a vitamin D t…

And to be very honest, whenever I read articles about the dangers of excess Vitamin D seems I'm reading an article on the dangers of malnourishment. In a country of obese people.

Yes, don't mega dose but you have to go out of the way and ignore all warnings and be reckless. It's the equivalent of "hey, how much aspirin should I take?" And just take a random amount

I do take it, but I know how much of the RDA that corresponds to

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#109

Post by he991z »

vecter wrote: post #32

I had a mini-episode of this earlier this year. Reposting as a warning for people: I had mild Vitamin D deficiency which was diagnosed by a doctor many years ago. I was given Vitamin D supplements, which I stocked up on more than usual recently due to my staying in all day due to WFH and not getting any sunlight. I used to take 50mcg of D3 1-2x a week and I upped that (without consulting a doctor) to 5x a week. Withi…

I had the exact same thing - too much thirst, even with low doses (1000-2000IU), but especially with 4000Iu or 5000IU, and really a lot with the 60kIU which the doctor originally prescribed. But the doctor advised to keep on taking vitamin D, as my levels were low. A second opinion from another doctor was no different. I did some research on my own and figured out it could be because of a Magnesium deficiency. I started taking Magnesium supplement and after supplementing for some time resumed the vitamin D along with Magnesium, and that fixed the thirst issue. If I would take vitamin D without magnesium, the thirst problem would come back. Even now if I take high dose vitamin D or even a calcium supplement without taking Magnesium, it leads to a lot of thirst. It's been a long time but from what I remember, I figured that it was because of vitamin D's effect on Calcium levels and the (electrolytic?) balance between Calcium and Magnesium in the body.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#110

Post by tzs »

Florin_Andrei wrote: post #75
ram_rar wrote: post #6

Taking 130,000UI per day for 20 months is insane. Most of the over the counter doses are ~ 5000UI. I'm curious, as to what was the patients diet like? Vit D is a fat soluble vitamin and its my understanding that one needs to eat healthy fats for it to be absorbed by the body.

> Most of the over the counter doses are ~ 5000UI. In what universe? In this one, doses I've seen are around 1k UI.

Here are some 5k and 10k available OTC.

10000 IU [1].

5000 IU [2] [3] [4].

[1] https://www.cvs.com/shop/nature-s-bounty-vitamin-d3-softgels...

[2] https://www.cvs.com/shop/nature-made-vitamin-d-5000-i-u-soft...

[3] https://www.cvs.com/shop/nature-s-bounty-vitamin-d3-softgels...

[4] https://www.cvs.com/shop/cvs-health-vitamin-d-softgels-5000i...

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