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How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

pubmed.ncbi.nlm.nih.gov

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Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#91

Post by Izkata »

voisin wrote: post #54
LegitShady wrote: post #39

Earlier quoted context omitted.

most of the supplements I've seen here are 1000ui, meaning she'd have to take 130 of the pills. It makes more sense when you realize there are liquid forms of d3 you can buy which probably make it much easier to dose really high.

In Canada at least anything over 1,000 IU in a pill needs to be prescribed (at which point I think it is an injection but I might be wrong). You’ll never find larger for sale.

In the US, was looking a week or two ago, I remember seeing 2000 IU pills available over the counter, and I think I saw 3000 IU as well (can't remember that one for sure though).

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#92

Post by lukeschlather »

e9 wrote: post #79
fizwhiz wrote: post #53

Earlier quoted context omitted.

Do you dose the D3/K2 combo on a daily basis? I've got https://amzn.com/B075R56QCQ which i do ~3 times a week.

I did that every day and started to have muscle pains and weakness after a while. After doing some research and experimentations, turns out you also need to take magnesium if that happens.

Every day year-round or just in winter at high latitudes?

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#93

Post by PragmaticPulp »

hammock wrote: post #19
PragmaticPulp wrote: post #5

The title doesn’t match the abstract. This isn’t a study of the tolerable upper limit of Vitamin D intake. It’s a case report of a single individual who was taking astronomical doses of Vitamin D with disastrous consequences. It’s certainly possible to take too much vitamin D without coming anywhere near the silly doses this person was consuming. Anyone taking aggressive vitamin D doses should invest in a vitamin D t…

Everything you say is subjective (at best) or tautological (at worst) until you put a number to what you are calling a "megadose" or "excessive." "Megadose" is relative and needs to be couched with the emerging (not really, it's a decade old at least I believe) that the current official RDA of vit D is about 4-5x TOO LOW and was based on bad data (or a misinterpretation of the data).

> Everything you say is subjective (at best) or tautological (at worst) until you put a number to what you are calling a "megadose" or "excessive."

The Vitamin D blood level range is clearly indicated on the blood test results. That’s why I suggested that people get the blood test.

Blood test shows too little Vitamin D? Supplement more. Blood test shows you’re approaching or exceeding the upper limit? Supplement less.

There’s nothing subjective about it.

> the current official RDA of vit D is about 4-5x TOO LOW and was based on bad data (or a misinterpretation of the data).

This claim, however, is unbounded. We can’t just go around telling people “more is better” and that the official recommendations are vaguely “too low” and expect people to just guess at the real range.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#94

Post by dragonwriter »

Izkata wrote: post #91
voisin wrote: post #54

Earlier quoted context omitted.

In Canada at least anything over 1,000 IU in a pill needs to be prescribed (at which point I think it is an injection but I might be wrong). You’ll never find larger for sale.

In the US, was looking a week or two ago, I remember seeing 2000 IU pills available over the counter, and I think I saw 3000 IU as well (can't remember that one for sure though).

I have 5000 IU pills, OTC.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#95

Post by PragmaticPulp »

tomhoward wrote: post #69

Another concern with Vit D supplementation is magnesium. As calcium and magnesium compete for absorption, Vit D’s effect of increasing calcium absorption can reduce magnesium absorption and lead to symptoms related to magnesium deficiency. I gather the toxic effects described in the article are partly due to extreme magnesium deficiency along with other effects - though magnesium or other effects aren’t mentioned in…

Unfortunately, magnesium has become another common target of megadosing pseudoscience on the Internet. It is possible to overdose on magnesium, despite popular belief.

Excess magnesium is eliminated very slowly, meaning overdose can happen after months of steady supplementation.

Anecdotally, gwern tracked some results after consistent magnesium supplementation and found a trend toward worsening after an initial boost: https://www.gwern.net/nootropics/Magnesium

I think we’re going to look back at this period of high-dose vitamin exuberance with a lot of regret. It’s relatively easy to hit optimal levels of all vitamins with basic attention to one’s diet. We already have several studies showing that multivitamin supplementation is slightly negatively correlated with longevity in elderly populations (or at least statistically insignificant). These people taking unnaturally large amounts of vitamins are in uncharted territory.

> As I’ve had evidence of Mg deficiency, I’ve been taking magnesium malate for a while, but am now looking at the more absorbable forms magnesium l-threonate and magnesium bisglycinate.

Two suggestions:

1) Don’t guess. Get a blood test to check for low magnesium levels. There are too many bad sources of information on the internet that attribute vague symptoms to magnesium deficiency with little supporting evidence. Getting a blood test is cheap.

2) Don’t bother with exotic higher bioavailability supplements. Just take more of the cheap stuff. If the cheap stuff has (example) 20% bioavailability and the expensive stuff has 40%, you’re almost always better off just taking twice as much of the cheap stuff.

Another complication is that the L-threonate and glycine in the more exotic formulations isn’t entirely inert. Glycine, for example, is well studied to improve sleep when taken on an empty stomach. A lot of those glowing reviews of “magnesium” for sleep are from people taking magnesium glycinate and then mis-attributing the effects of the glycine to the magnesium because they read glowing reviews of magnesium on the Internet. It’s a mess out there.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#96

Post by baccheion »

The idea is to push PTH to the bottom of the range. Can be done with a combination of calcium and vitamin D. Get more calcium (maximum 2:1 Ca:Mg) than phosphorus. Serum 25(OH)D at 40(-60) ng/mL or greater.

More vitamin D3 can be handled if taking higher amounts of vitamin K2 (at least 1mg MK-4 and 100 mcg MK-7 per 10,000 IU) and magnesium.

Could also add (sustained-release) melatonin if done growing to balance D3 in the AM.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#97

Post by hexbinencoded »

e9 wrote: post #79
fizwhiz wrote: post #53

Earlier quoted context omitted.

Do you dose the D3/K2 combo on a daily basis? I've got https://amzn.com/B075R56QCQ which i do ~3 times a week.

I did that every day and started to have muscle pains and weakness after a while. After doing some research and experimentations, turns out you also need to take magnesium if that happens.

That sounds like too much, which can cause calcium deposition in soft tissues. I'm 250 lbs / 113 kg and only take 125 μg (mcg) of D3 and 100 of K2 MK-7 once every other day (qod) because of D status for COVID prophylaxis and chronic premature distal osteoarthritis.

Calcium, magnesium, sodium, and potassium in balanced amounts along with K and D maximize bone health. Alkali metals supplementation alone is rarely a good idea because of the often common transports and osmotic competitions.

In general, a multivitamin, b complex, and omega 3 in the form of canned fresh sardines or anchovies (fish oil capsules are typically low in actual 3 and high in 6) is probably enough for most people.

5-10 mg/day of extra zinc during the annual cold season is fine too.

Don't supplement with E without a specific medical need.

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#98

Post by tedunangst »

e9 wrote: post #82
TedDoesntTalk wrote: post #62

Earlier quoted context omitted.

Why would you need so much?

If you do strenuous workouts frequently then this helps you recover faster and workout longer. If you are just couch potato then it’s actually detrimental and you can develop all sorts of problems including peripheral neuropathy.

Is there reason to believe that 10x vitamin B is insufficient to recover from a workout?

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#99

Post by juandazapata »

kevinmgranger wrote: post #24
PragmaticPulp wrote: post #5

The title doesn’t match the abstract. This isn’t a study of the tolerable upper limit of Vitamin D intake. It’s a case report of a single individual who was taking astronomical doses of Vitamin D with disastrous consequences. It’s certainly possible to take too much vitamin D without coming anywhere near the silly doses this person was consuming. Anyone taking aggressive vitamin D doses should invest in a vitamin D t…

Megadosing B12 (if your diet isn't already sufficient in it, which is common amongst certain vegan diets) is still a good idea, no? I recognize this might be the only exception.

Megadosing B12 gave me dizziness and trouble sleeping (I had hypervitaminosis)

Re: How Much Vitamin D Is Too Much? A Case Report and Review of the Literature

#100

Post by fluder »

mcswell wrote: post #86
fluder wrote: post #83

This can be just MS relapse, non related to Vit D overdose.

...which is of course why the patient got better when they went off the Vit D.

When RRMS you always will be better some time later, even without treatment. Just trust me, i have this shit many years.
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