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Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

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Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#121

Post by LocalH »

I’ve had more help with my ADHD symptoms from a series of DMT experiences, than I ever did from the mainstream treatment process. One single DMT experience (containing about an objective hour of intensely being dragged through time) greatly minimized my ADHD symptoms for at least six months. There is untapped potential in psychedelics for treatment of things like this. It’s a crime against humanity that we allowed neurotypicals to decide for everyone how these neurochemistries are managed.

ADHD treatment is not ADHD friendly. Society is not ADHD friendly. Neurotypicals literally have the same scale of mental privilege as whites do in a racial context.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#122

Post by whimsicalism »

dr_dshiv wrote: post #89
kqr wrote: post #71

Earlier quoted context omitted.

> You know what's totally nuts? Taking Amphetamine daily for years in reasonable doses essentially has no long term negative effects. In that way, similar to coffee. This is a null hypothesis that hasn't been refuted due to lack of evidence, and not an alternative hypothesis that has been proven by evidence, right? I ask because I've been looking into this before, and from what I remember there was virtually no evide…

Well, it's scientifically difficult to randomly assign people and assess effects for multiple decades. So the ideal evidence won't be available. But if we accept a "nutrition science" level of evidence, then I'd say there is strong evidence showing the naturalistic longterm use of adhd meds is not dangerous. Especially considering our baysian prior: a person off the street would estimate far stronger negative effects…

> In fact, adhd meds are correlated with healthier outcomes (of course, huge selection effects. Yes, eating kale will be associated with increased health, but it isn't causal)

Yeah, I'd say p much impossible to untangle there without experimental evidence.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#123

Post by whimsicalism »

winter_blue wrote: post #105
dr_dshiv wrote: post #69

Earlier quoted context omitted.

You know what's totally nuts? Taking Amphetamine daily for years in reasonable doses essentially has no long term negative effects. In that way, similar to coffee. When I think about that, it's kind of mind blowing. For that matter, it is also crazy that we don't start giving children coffee at younger ages to help focus — since there are no known negative effects. It's just a cultural trope that it stunts growth, et…

> You know what's totally nuts? Taking Amphetamine daily for years in reasonable doses essentially has no long term negative effects. In that way, similar to coffee. Wow, that is truly amazing. I'm glad to learn about that. I notice a slight depression if I stop taking my ADHD meds for a few days (perhaps up to a week), but after that I'm back to my old (ADHD-driven) self. So in a sense, it's not addictive at all. Th…

> So in a sense, it's not addictive at all.

You definitely have a withdrawal from adderall. A few days (up to a week) is typical of most drug withdrawals.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#124

Post by M0T0K0 »

I'm eternally annoyed that nobody on this page mentions the Racetams (Aniracetam, Piracatam, etc.) as potential alternatives to dosing speed everyday. I myself began to have heart issues from even just Ritalin (mild perhaps compared to Addy or Vyvanse).

Fasoracetam in particular looks promising but seems to be stuck in approval limbo:

https://nootro.info/fasoracetam-adhd-treatment/

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#125

Post by aantix »

_dibly wrote: post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

Curious if you've ever done a hair follicle mineral test to check for mineral deficiencies?

We've been working through the book, "Finally Focused", to help our son. Magnesium supplementation is recommendation #1, Iron supplementation (if deficient as demonstrated by the test) and then the over-the-counter, lithium orotate. We haven't gotten further than chapter 3, yet.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#126

Post by justinko »

acituan wrote: post #98
dr_dshiv wrote: post #69

Earlier quoted context omitted.

You know what's totally nuts? Taking Amphetamine daily for years in reasonable doses essentially has no long term negative effects. In that way, similar to coffee. When I think about that, it's kind of mind blowing. For that matter, it is also crazy that we don't start giving children coffee at younger ages to help focus — since there are no known negative effects. It's just a cultural trope that it stunts growth, et…

> we don't start giving children coffee at younger ages to help focus > we are inhibiting our full potential because of misplaced fears? I'll argue with the assumption that there is zero long term psychobiological consequences to exogenous psychostimulants (I personally don't buy this, but let's assume it was true). Increasing focus and task salience is only one of the many factors constitutive of human potential. Th…

I’ve read a lot of comments around amphetamines. This is probably my favorite.

Amps turn you into a drone. Any perceived benefit is met with equal or greater detriment.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#127

Post by justinko »

pen2l wrote: post #39
PragmaticPulp wrote: post #37

Earlier quoted context omitted.

> I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. That's not entirely true, though. There is a lot of value in learning good habits to cope with ADHD and developing systems and mental models to improve your ADHD situation. ADHD isn't a purely…

> In short, I'd encourage you to continue addressing your ADHD symptoms with ever-improving self discipline, personal habits, and healthy lifestyle choices. The medication is part of a treatment regimen, but it shouldn't be the entirety of one's treatment regimen. No, no, no, no. As someone who suffered remarkable mental turmoil over my inability to focus, despite reading books about it, asking everyone for help with…

Perhaps school and college were the problems and not your ADHD?

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#128

Post by Izkata »

_dibly wrote: post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

> When I was younger I was perscribed ritalin, and it just made me sleepy so I stopped taking it. Now I take a more modern medication and it works wonders.

I don't have ADHD, but I'm curious what the modern one is.

Back in middle school, around 2001, I did a report on ADD and ADHD, and 3 of the medications that existed for it: Ritalin, Cylert, and I'm not certain of the third but from the other comments Adderall sounds like it could be it (though I think it started with a "D", is there one that does?). The only thing I remember from it is the conclusion that if I got diagnosed and needed medication, I'd refuse Ritalin, and that Cylert seemed like the best of the three.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#129

Post by jdc »

M0T0K0 wrote: post #124

I'm eternally annoyed that nobody on this page mentions the Racetams (Aniracetam, Piracatam, etc.) as potential alternatives to dosing speed everyday. I myself began to have heart issues from even just Ritalin (mild perhaps compared to Addy or Vyvanse). Fasoracetam in particular looks promising but seems to be stuck in approval limbo: https://nootro.info/fasoracetam-adhd-treatment/

Cf. phenylpiracetam - developed for the Soviet cosmonauts in '83

https://en.wikipedia.org/wiki/Phenylpiracetam

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#130

Post by anonybadger »

_dibly wrote: post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

Curious - what’s the more modern medication that you take! Thanks.
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