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MS treatment a step closer after drug shown to repair nerve coating

theguardian.com

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Re: MS treatment a step closer after drug shown to repair nerve coating

#101

Post by LinuxBender »

rikelmens wrote: post #91

L-carnosine is VERY promising for MS treatment. It's been found that carnosine levels are significantly decreased in both animal MS models and humans with MS. [1] This [2] completed (results pending) small study will try to verify if supplementing with carnosine will help slow down the progress of or even reverse MS. Unofficially, I've heard it was a great success. But let's wait. Edit: Just found another completed s…

Ive used L-carnosine in conjunction with zinc, l-glutamine, keto+IF to repair a serious aspirin lesion in my gut and it worked great. I've read that benfotiamine can also help with myelin repair but do not have the studies handy.

Re: MS treatment a step closer after drug shown to repair nerve coating

#102

Post by peterlk »

panabee wrote: post #83
melling wrote: post #61

Earlier quoted context omitted.

So, that wouldn’t be a good way to address basic medical research for some sort of Manhattan project. To make great progress over a decade, we’d need to do something else to advance medical science.

what's the craziest idea you have heard of that would advance medical science?

Usage of BIL Gates in gene therapy - https://en.m.wikipedia.org/wiki/Transcriptor

The possibilities boggle my mind

Re: MS treatment a step closer after drug shown to repair nerve coating

#103

Post by faeyanpiraat »

treeman79 wrote: post #84
6d6b73 wrote: post #80

Earlier quoted context omitted.

Check out Wahls Protocol.

Looks similar to AIP diet. All anti inflammatory foods

I’m not convinced these diets work as advertised..

I’ve read tons of scientific papers and there are too many contradictions.

For example these diets tend to forbid gluten intake, but some research imply better outcomes for patients with high whole grain intake.

I’ve also read that inflamation is useful for preventing cancer, so what good is not having relapses when you get cancer from all the anti imflammatory stuff..

Re: MS treatment a step closer after drug shown to repair nerve coating

#104

Post by justinclift »

thowaway1001 wrote: post #4
bognition wrote: post #2

It’s kind of disappointing that this drug won’t be used as a treatment. I get that this drug has dangerous side effects but life with MS is terrible and the life expectancy is short 5-10 years. I fully believe that for chronic life threatening diseases people should be allowed to try all sorts of treatments that would be deemed unsafe.

It mat not be only the safety profile, but also the fact that drug patent has expired in 2016. I am sure they’ll come up with an alternative that may have similar or better safety profile and could pay for clinical trials. No company is going to finance Phase 3 trial on patent free drug.

Are you meaning the expiry of the 1999/2000 patents? There seem to be several others, including some filed recently:

https://www.drugpatentwatch.com/p/generic-api/BEXAROTENE

On a side note, is anyone aware of better info source that "drugpatentwatch.com"? That site seems to lock useful info behind a paywall.

Re: MS treatment a step closer after drug shown to repair nerve coating

#105

Post by taurath »

faeyanpiraat wrote: post #103
treeman79 wrote: post #84

Earlier quoted context omitted.

Looks similar to AIP diet. All anti inflammatory foods

I’m not convinced these diets work as advertised.. I’ve read tons of scientific papers and there are too many contradictions. For example these diets tend to forbid gluten intake, but some research imply better outcomes for patients with high whole grain intake. I’ve also read that inflamation is useful for preventing cancer, so what good is not having relapses when you get cancer from all the anti imflammatory stuff…

In theory if you’re comparing white bread eaters to whole grain eaters I’d imagine there would be a net benefit. I wonder if whole grain vs no grain has been studied.

Re: MS treatment a step closer after drug shown to repair nerve coating

#106

Post by Madmallard »

faeyanpiraat wrote: post #103
treeman79 wrote: post #84

Earlier quoted context omitted.

Looks similar to AIP diet. All anti inflammatory foods

I’m not convinced these diets work as advertised.. I’ve read tons of scientific papers and there are too many contradictions. For example these diets tend to forbid gluten intake, but some research imply better outcomes for patients with high whole grain intake. I’ve also read that inflamation is useful for preventing cancer, so what good is not having relapses when you get cancer from all the anti imflammatory stuff…

Are you deep in biology like with a minimum BS or higher degree? If not, might just be too difficult to understand the value of the ideas. The lady prescribing the Wahls protocol is an MD so has a lot more invested into the field than the layperson. That said, she could still be wrong.

One thing is for sure, there is no one-size-fits-all and there is no magic bullet. If there's something helpful for one condition, it's probably harmful for another. The body is a complex holistic system after all.

Re: MS treatment a step closer after drug shown to repair nerve coating

#107

Post by refurb »

aplummer wrote: post #89
melling wrote: post #61

Earlier quoted context omitted.

So, that wouldn’t be a good way to address basic medical research for some sort of Manhattan project. To make great progress over a decade, we’d need to do something else to advance medical science.

The thing is honestly, we make incredible progress every decade. What's important is doing it carefully, correctly, and investing in the right areas to make real positive change (less viagra and hair loss probably). Just a decade ago, Hepatitis C wasn't curable in nearly 100% of patients (in 12 weeks with limited side effects!). It isn't great news cycle content to focus on rehashing the great achievements we have re…

I work in the industry and I agree we make remarkable progress now. And for some technologies like CAR-T and gene therapy, we’ve just started.

Your HCV example is a great one. Before the anti-virals, it was interferon. You had to take it for months and from talking to people, it makes you feel like you have the flu...for months. The label actually describes a risk of suicide. It’s a very rough drug to be on and the cure rate is Today, we have regimens that are weeks in length, minimal side effects and 99% cure rates across all genotypes.

You’re talking about going from a very difficult to cure, chronic condition that can lead to liver failure or liver cancer to just being cured after 12 weeks.

It’s absolutely remarkable.

Re: MS treatment a step closer after drug shown to repair nerve coating

#108

Post by doctor_eval »

nnmg wrote: post #29
doctor_eval wrote: post #15

Earlier quoted context omitted.

I don’t think it’s that settled at all, certainly not in 1965. Prineas in 2001 showed that MS progression may occur in the absence of immune cells and inflammation, for example [0], and people have complained of progression even when taking extremely strong immunosuppressants. While involvement of the immune system seems likely, and certainly most treatments target the immune system, I don’t think causality has been…

> Prineas in 2001 showed that MS progression may occur in the absence of immune cells and inflammation MS researcher here. MS as an autoimmune attack is largely settled in mainstream neuroscience. The paper you cited does not show what you said it does. From the paper: > restricted largely to short segments of disrupted myelin located within linear aggregates of microglial cells The paper is interesting because it sh…

OK. I might be quoting the wrong paper, and I’m not a researcher, but I remember clearly that he found a case (14yo girl IIRC) who died during an attack, and there was no immune activity at the site of at least one of the lesions.

If I’m wrong about this then I will accept it, I don’t have an axe to grind.

Re: MS treatment a step closer after drug shown to repair nerve coating

#109

Post by marta_morena_29 »

faeyanpiraat wrote: post #103
treeman79 wrote: post #84

Earlier quoted context omitted.

Looks similar to AIP diet. All anti inflammatory foods

I’m not convinced these diets work as advertised.. I’ve read tons of scientific papers and there are too many contradictions. For example these diets tend to forbid gluten intake, but some research imply better outcomes for patients with high whole grain intake. I’ve also read that inflamation is useful for preventing cancer, so what good is not having relapses when you get cancer from all the anti imflammatory stuff…

This made me laugh. You read tons of scientific papers? Good for you. As anyone with an auto-immune disease and seriously interested in healing can tell you: AIP, if followed to the letter, works absolute wonders within even just a single god-damn day. But sure, read your papers... I am sure they are funded by people who have a huge interest in the result that you can cure 30% of the general population by merely changing their eating habits, as opposed to prescribing drugs that cost a fortune and going through all the hoops of the expensive medical system. Yeah, sounds really clear to me, these papers have it right.

> tend to forbid gluten intake

They don't tend to. Any diet who doesn't absolutely forbid gluten intake doesn't work. Simple as that. Gluten is one of the primary factors of developing auto-immune diseases and ergo also treating them.

> whole grain

Yeah better. Totally :). Because as opposed to white bread, whole grain bread contains all the goodies of mother nature in full force, like all the poison these flowers made against mammals to survive digestion. Bon appetite!

> get cancer from all the anti imflammatory stuff.

Totally makes sense. Yeah, eat healthy and you get cancer. You really made my day :D. You are just randomly mixing totally unrelated research results into something that is utterly wrong.

Good luck on your journey!

Re: MS treatment a step closer after drug shown to repair nerve coating

#110

Post by jpk »

marta_morena_29 wrote: post #109
faeyanpiraat wrote: post #103

Earlier quoted context omitted.

I’m not convinced these diets work as advertised.. I’ve read tons of scientific papers and there are too many contradictions. For example these diets tend to forbid gluten intake, but some research imply better outcomes for patients with high whole grain intake. I’ve also read that inflamation is useful for preventing cancer, so what good is not having relapses when you get cancer from all the anti imflammatory stuff…

This made me laugh. You read tons of scientific papers? Good for you. As anyone with an auto-immune disease and seriously interested in healing can tell you: AIP, if followed to the letter, works absolute wonders within even just a single god-damn day. But sure, read your papers... I am sure they are funded by people who have a huge interest in the result that you can cure 30% of the general population by merely chan…

I down-voted this comment for its tone. This is a thorough and well-informed rebuttal of the parent comment, but it's buried under an unnecessary layer of sass and sarcasm. I appreciate your passion, but we can do better than this.
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