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The First Randomized Controlled Trial on Vitamin D and Covid-19

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Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#121

Post by amelius »

dcolkitt wrote: post #31
autokad wrote: post #22

when i was doing the covid19 kaggle competitions in march and april, someone asked me what I learned. I was like I dont know, the data is messy but the sun seems to have something to do with reducing fatalities. (I used weather data as additional covariates)

In general, the segment of the population that avoids sun exposure has twice as high an all-cause mortality rate as the segment that actively seeks sun exposure.[1] To put that in context that's on par with the health difference found between smokers and non-smokers. [1] https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12251

Maybe also because staying inside makes it easier for the virus to spread.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#122

Post by jerf »

vore wrote: post #120
tboyd47 wrote: post #118

Good on you, Spain. A study like this could never take place in the USA :( Too many powerful people are heavily invested in the belief that there is no treatment for it.

Seems like a ridiculous claim when I'm sure almost absolutely everyone would like to get out of this mess.

It shouldn't be hard to sit for a moment and think of some people who would certainly like for there not to be a treatment consisting of ~$3-5 worth of off-the-shelf, completely unpatentable medicines and vitamins.

There are absolutely some powerful vested interests in not seeing an easy treatment for this disease, or, by the same logic, pretty much any other disease either since there's nothing special about this one. (A not infrequent complaint on Hacker News.) I can't prove they're driving the discourse on treatment for COVID-19, but it sure isn't disproved by what I see happening out there.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#125

Post by tboyd47 »

vore wrote: post #120
tboyd47 wrote: post #118

Good on you, Spain. A study like this could never take place in the USA :( Too many powerful people are heavily invested in the belief that there is no treatment for it.

Seems like a ridiculous claim when I'm sure almost absolutely everyone would like to get out of this mess.

You cannot fast-track a vaccine if there are other treatments available. Letting the word out that you can be cured from COVID-19 could make a lot of people lose much money. Both Vitamin D and the other one (it rhymes with byfroxymorophin) are cheap and out of patent.

* https://www.fda.gov/patients/fast-track-breakthrough-therapy...

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#128

Post by jmalicki »

extremeMath wrote: post #102
mft_ wrote: post #19

Earlier quoted context omitted.

It’s more likely to kill old and obese people, but there are still plenty of rarer cases of harm to younger fitter people (eg triathletes on oxygen post-infection). It’s not binary.

I'm more concerned about the 30% of Americans that are obese than the 0.1% top athletes, who in rare circumstances are badly affected. Open the gyms to save lives.

Truly obese people can benefit a lot from just walking, as they're not trained enough to need high intensity exercise to keep it up.

Gyms are pretty horrible places for spreading COVID and other respiratory infections, as they involve a lot of heavy breathing in confined spaces. They are probably a worse place to be than bars. Would the increase in fitness over a 6 month period for a typical obese person really reduce the risk by more than being in the gym increases it?

https://wwwnc.cdc.gov/eid/article/26/8/20-0633_article https://www.healthline.com/health-news/heres-why-covid-19-ca...

Pre-COVID studies of gyms call out a very high risk factor for respiratory infections.

https://www.researchgate.net/publication/324993154_Infection...

There was one RCT of gym access in Norway that showed no difference, but that's because there was only one case out of over three thousand during the entire study, in either arm, so it's difficult to say that means anything at all.

https://www.medrxiv.org/content/10.1101/2020.06.24.20138768v...

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#129

Post by [deleted] »

jerf wrote: post #122
vore wrote: post #120

Earlier quoted context omitted.

Seems like a ridiculous claim when I'm sure almost absolutely everyone would like to get out of this mess.

It shouldn't be hard to sit for a moment and think of some people who would certainly like for there not to be a treatment consisting of ~$3-5 worth of off-the-shelf, completely unpatentable medicines and vitamins. There are absolutely some powerful vested interests in not seeing an easy treatment for this disease, or, by the same logic, pretty much any other disease either since there's nothing special about this on…

[deleted]

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#130

Post by koboll »

jogundas wrote: post #23
LinuxBender wrote: post #16

Earlier quoted context omitted.

Hydroxychloroquine is a zinc ionophore which helps zinc get into the cells in your lungs and slows the viral replication. It was not designed to be used this way, it just happens to work. This is mostly useful before your viral load is high. Same goes for Quercetin, also a zinc ionophore. They are good proactive measures to slow down the viral transcription before you reach a critical stage. It won't help everyone, e…

Wiki says that "Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects." https://en.wikipedia.org/wiki/Hydroxychloroquine

Here's a good rundown from Science on why hydroxychloroquine has failed large RCTs:

https://www.sciencemag.org/news/2020/06/three-big-studies-di...

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