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The First Randomized Controlled Trial on Vitamin D and Covid-19

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Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#81
post #30

Non-white skinned people: sunlight may not be enough to increase your vitamin D. https://www.google.com/search?q=dark+skin+vitamin+d+minutes

Is there a scientific classification system for evaluating how light vs. dark a person's skin is? I'd like to know how much my relatively darker skin is preventing vit D uptake / creation in the body

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#82

Earlier quoted context omitted.

I've been taking Vitamin D3 5000 IU and Vitamin K2 MK-7 100 mcg daily since February to boost my immune system, and I've noticed a radical difference in my colds. I used to get a major cold every 2-3 month and they were really bad lasting two weeks with fever, fatigue, coughs, colds, really stuffy nose, etc. Now? The two colds I've had were over in a week and the symptoms were so incredibly mild - mostly a light runn…

Are you sure you just aren't getting colds because of better hygiene, and less contact with others? Without controlling for social distancing, you can't reasonably conclude that it was the vitamin D. I haven't had a cold since we initially locked-down in April, which is very unusual for me, but completely explained by social distancing.

> you can't reasonably conclude that it was the vitamin D.

Except you can, because that is the conclusion of at least one other study of the effect of Vitamin D. https://pubmed.ncbi.nlm.nih.gov/16959053/

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#83

Earlier quoted context omitted.

My understanding is that it hasn’t been shown for elevators. I think this is because of the required time to breathe in a minimal viral load. Do you have evidence otherwise?

Yes I heard planes as well surprisingly safe relative to choir practice. Environments where lots of droplets are created are less safe...

My understanding is that planes have very effective air filtration and movement systems. Choir practice likely would not, and involved people generating aerosols continuously.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#84
post #47

Earlier quoted context omitted.

Don't really know why you haven't found the most obvious explanation for why you've gotten fewer colds.

Vitamin D has a direct effect on colds. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949172/

Another study to back you up: https://pubmed.ncbi.nlm.nih.gov/16959053/

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#85

Earlier quoted context omitted.

I've been taking Vitamin D3 5000 IU and Vitamin K2 MK-7 100 mcg daily since February to boost my immune system, and I've noticed a radical difference in my colds. I used to get a major cold every 2-3 month and they were really bad lasting two weeks with fever, fatigue, coughs, colds, really stuffy nose, etc. Now? The two colds I've had were over in a week and the symptoms were so incredibly mild - mostly a light runn…

Are you sure you just aren't getting colds because of better hygiene, and less contact with others? Without controlling for social distancing, you can't reasonably conclude that it was the vitamin D. I haven't had a cold since we initially locked-down in April, which is very unusual for me, but completely explained by social distancing.

Oh I absolutely believe that social distancing and better hygiene are the reasons why I've gotten so few colds this year but those actions can't fully explain the decrease in severity. My colds have gone from being absolutely miserable to barely noticeable and are over in a week or less. I could be totally wrong but I'm not willing to remove vitamin d/k/c from my diet just to validate the hypothesis.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#86

Earlier quoted context omitted.

You don't need masks if you are maintaining distance of 6 feet. Masks are for situations where distance can not be maintained such as trains and stores.

Evidence suggests that aerosols can remain in the air for minutes after being placed there by another non-masked individual. You could pass through the aerosol and inhale. Masks make sense outside too, at least in some circumstances.

Considering that the risk of transmission seems to depend on how long you are inhaling shared air from an infected person, and their viral load, I don't think it makes sense to worry about intermittently going through someone else's exhaust plume.

I use a mask outside if I'm on a narrow sidewalk, but otherwise, I don't think there's much point. My favourite thing is the people who wear a mask over the mouth, but not the nose. Like worst of both worlds.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#87

And that's why I've been taking Vitamin D pills for the past 6 months. (It's been suspected for some time to have an effect) This doesn't mean go outside and get covid.

Be careful. Vitamin D is a hormone and is not risk-free. Unless you have been prescribed by your doctor. In general, be careful with any fat-soluble "vitamins", as they can build up.

This is kind of a silly thing to be worried about with Vitamin D.

Yes it's fat soluble. But the amount you would need to take in supplements to cause a problem is enormous. (Every vitamin is different)

You could probably take an entire bottle and you'd be fine.

The patients in this study were being given 10x the RDA, about 20k IU/day.

You can very very easily get 25k IU out in the sun and your body has no issues.

It's safe to take 2000IU/day and make sure to get sun if possible.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#88
post #76

This is not a strong signal. The adjusted odds ratio is 0.03 (95% CI: 0.003 - 0.25). For randomised trials, it makes no sense to say that the difference in baseline is not significant because we have already observed the outcomes. It is better to use ASDs and in such small trials, small differences in baseline matter a lot. In this case it's pretty obvious the effect of vitamin D would easily be non significant if yo…

Can you elaborate? As a statistical noob, this feels like a huge effect (1 of 50, or 2% - vs - 13 of 26, or 50%).

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#90

"Don't go outside, you'll get COVID", sounds more and more like horrible advice. Before knowing the virus died in sunlight, I still couldn't fathom why people were avoiding going out to parks and stuff. It was totally non sequitor.

There's a major difference between daylight and getting baked under direct solar irradiation.

If the UV doesn't kill the virus the heat will. But even then, it's not immediate. If droplets containing viruses successfully land in your respiratory system (which is constantly sucking air), it doesn't matter how much sun there is outside, the virus is now cozy.

A beach could be perfect, except that there may be strong winds. You should hope they are not blowing droplets from your neighbor into you.

Similarly, if it's an overcast day, it doesn't really matter much.

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