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The First Randomized Controlled Trial on Vitamin D and Covid-19

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Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#71

Earlier quoted context omitted.

Be careful. Vitamin D is a hormone and is not risk-free. Unless you have been prescribed by your doctor. In general, be careful with any fat-soluble "vitamins", as they can build up.

A daily dose of 2000-4000 is enough and is very safe. 42% of Americans are deficient, much more the darker your skin is. https://www.healthline.com/nutrition/vitamin-d-deficiency-sy...

Could help explain why COVID-19 is much more severe (on average) if you’re black...

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#72

Earlier quoted context omitted.

You should almost certainly be going outside for the other health benefits. There's very little risk of transmission if you're outside and 2m away from other people, even if intermittently you're closer than that. Even more so if one or the other of you is masked. Places to be more concerned about are bottlenecks like lobbies and elevators on the way to/from outside.

My understanding is that it hasn’t been shown for elevators. I think this is because of the required time to breathe in a minimal viral load. Do you have evidence otherwise?

> My understanding is that it hasn’t been shown for elevators. I think ...

Where are you getting this understanding? You are asking for evidence while providing none yourself...

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#73
post #26

Looks promising, but I would want to see a true double blinded RCT on a few thousand people before we say that Vitamin D is an effective treatment. Also, there's going to be a confounding question based on this study: is it just Vitamin D, or is it Vitamin D in combination with HCQ / Azithromyacin? That said, it probably wouldn't hurt you to supplement with Vitamin D this winter, even if it doesn't treat Covid.

It's difficult to imagine how the placebo effect could produce this result. Both arms of the trial were receiving HCQ and Azithromycin, so to the extent that there is a placebo effect, you'd think that adding a vitamin wouldn't change the result very much.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#74
post #39

Earlier quoted context omitted.

Wiki says that "Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects." https://en.wikipedia.org/wiki/Hydroxychloroquine

millions of people take HCQ on a daily basis for their lupus. Ask any rheumatologist, the danger of Torsades de Points is only a concern for HCQ if the patient already has a serious heart condition, or if the patient has been taking HCQ for years. Millions more take HCQ as a malaria treatment. It is generally recognized as safe, if you do not have a heart condition (and even then a short course is unlikely to yield a…

Covid has severe effects on the cardiovascular system, with myocardial injury being a frequent occurrence of those covid patients admitted to hospital.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#75
post #47

Earlier quoted context omitted.

I've been taking Vitamin D3 5000 IU and Vitamin K2 MK-7 100 mcg daily since February to boost my immune system, and I've noticed a radical difference in my colds. I used to get a major cold every 2-3 month and they were really bad lasting two weeks with fever, fatigue, coughs, colds, really stuffy nose, etc. Now? The two colds I've had were over in a week and the symptoms were so incredibly mild - mostly a light runn…

Don't really know why you haven't found the most obvious explanation for why you've gotten fewer colds.

Vitamin D has a direct effect on colds.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949172/

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#76
This is not a strong signal. The adjusted odds ratio is 0.03 (95% CI: 0.003 - 0.25). For randomised trials, it makes no sense to say that the difference in baseline is not significant because we have already observed the outcomes. It is better to use ASDs and in such small trials, small differences in baseline matter a lot. In this case it's pretty obvious the effect of vitamin D would easily be non significant if you shift around some variables. Reeks of p hacking imo

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#77

Earlier quoted context omitted.

Be careful. Vitamin D is a hormone and is not risk-free. Unless you have been prescribed by your doctor. In general, be careful with any fat-soluble "vitamins", as they can build up.

You would have to take crazy amounts of vitamin D - more than 250 mcg (10000 IU) - for it to be toxic [0][1]. [0] https://academic.oup.com/ajcn/article/85/1/6/4649294 [1] https://asbmr.onlinelibrary.wiley.com/doi/full/10.1359/jbmr....

Over a prolonged period of time...

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#78

"Don't go outside, you'll get COVID", sounds more and more like horrible advice. Before knowing the virus died in sunlight, I still couldn't fathom why people were avoiding going out to parks and stuff. It was totally non sequitor.

By going outside you are likely to spread the virus.

This does not appear to be true as of Sept 2020.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#79
post #39

Earlier quoted context omitted.

Wiki says that "Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects." https://en.wikipedia.org/wiki/Hydroxychloroquine

millions of people take HCQ on a daily basis for their lupus. Ask any rheumatologist, the danger of Torsades de Points is only a concern for HCQ if the patient already has a serious heart condition, or if the patient has been taking HCQ for years. Millions more take HCQ as a malaria treatment. It is generally recognized as safe, if you do not have a heart condition (and even then a short course is unlikely to yield a…

The dosages are different (much higher) for Covid-19.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#80
post #10
post #2

Noteworthy that this is in combination with anti-viral drugs at hospital admission: hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days). Regardless, I'm going to assume this means being outside and getting sun is good for me.

Except for all the skin cancer, right? FWIW, I was told that when the Sun is above 45 degrees over the horizon you will accrue DNA damage, and it stacks up over your entire lifetime. There is no "reset" or "heal", it just adds up. For that reason I'm doing my darnest best to stay in the shade between 9am and 3pm. Or covering clothing.

> you will accrue DNA damage, and it stacks up over your entire lifetime. There is no "reset" or "heal", it just adds up.

Sort of.

Every time your skin gets 'red' due to sun exposure... that's due to DNA damage.

However, cells have several mechanisms to repair DNA - otherwise we would be in serious trouble after a single radiation burn (which is what UV light does).

They might fully repair an event successfully. Or they might not - in which case the damage may be severe and the cell will either die due to its effects or detect and trigger apoptosis. If the error isn't serious, it might not be detected and be passed on to future cell generations. Those are the ones you need to worry about.

Specifically for the skin, given that skin cells divide quite frequently, they might be caught mid-division, which is a more vulnerable state.

As you get more exposure and more damage, the chances of defects not being properly repaired increase. So you are right that, if you keep letting your skin bake, chances are you will accumulate damage that can't be repaired(over a lifetime, that's a certainty).

Cancer is not the only issue. Have you seen how the skin of people that spent a lifetime working under the sun without adequate protection look like?

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