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Longevity FAQ: A beginner's guide to longevity research

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Re: Longevity FAQ: A beginner's guide to longevity research

#91
post #71
post #47

Food intake is regulated primarily by dietary protein and carbohydrate • Low-protein, high-carbohydrate diets are associated with the longest lifespans • Energy reduction from high-protein diets or dietary dilution does not extend life https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)...

...in mice, which evolved to eat mainly carbohydrates, while humans evolved to eat whatever they could

what's that rule about research that most research should come with the disclaimer "in mice"?

Re: Longevity FAQ: A beginner's guide to longevity research

#92
post #57

Earlier quoted context omitted.

Did people say that 20 years ago?

Yes we did. I was on transhumanist mailing lists twenty years ago and the exact same comments were being made then as are in this thread today

Lol. I seem to recall seeing a comic strip once, where a young, a middle-aged, and an old man were asked when anti-aging treatments would arrive. Their answers were respectively: fifty years, ten years–and this afternoon!

Re: Longevity FAQ: A beginner's guide to longevity research

#93
post #59

In 1897, philosopher Paul Janet came up with the model that current moments of time in our lives might be perceived by their "fraction of life lived thus far". This would seem to undermine the value of longevity somewhat: according to this visualization of the idea: https://www.maximiliankiener.com/digitalprojects/time/

Counterpoint: https://www.wolframalpha.com/input/?i=%5Cint_1%5Ewdx%2Fx

What does that integral show?

Re: Longevity FAQ: A beginner's guide to longevity research

#94

Earlier quoted context omitted.

Counterpoint: https://www.wolframalpha.com/input/?i=%5Cint_1%5Ewdx%2Fx

What does that integral show?

They are making the argument that total perceived time would still increase logarithmically as absolute time increases, even under the model discussed. (And doesn't, say, approach some fixed sum.)

Hence there's still a point to trying to live longer, even if the value of each additional time period decreases.

Anyway, that's if you agree that model! There's a couple of other things I'd consider without even examining it's core assumptions: memory fades over time - time earlier in my life might not contribute as much to my perceived time, as recent time does; what if you spend your early life just getting to the place you want to be (resources, self-development etc)? Extra time in that place could be very valuable!

Re: Longevity FAQ: A beginner's guide to longevity research

#96
post #72

Earlier quoted context omitted.

> As long as the fertility rate is less than 2 children/woman, the total population will still converge even if no one dies. Converge to what? How?

I think they mean the infinite sequence of Σ (generation_n) always converges to some finite number when generation_(n+1) = k * generation_n has k I don’t think that’s a good model, as people who want more offspring will out-reproduce those who don’t, but that’s an argument for another time.

> I don’t think that’s a good model, as people who want more offspring will out-reproduce those who don’t, but that’s an argument for another time.

This argument assumes the offspring behaves in the same way as their parents. I don't see that necessarily being true. Even if that is the case, there are legislative solutions.

Re: Longevity FAQ: A beginner's guide to longevity research

#97
post #87

Earlier quoted context omitted.

Do you have kids? I think my view on this radically changed as a father. I feel like my generation sticking around forever would come at the expense of our children (or their children, which by proxy is the same thing). With kids around, there’s just something biologically soothing that tells you “you’ve done your part. You can leave this world at peace”. I know it’s not the same for everyone but on a humankind level…

Those are beliefs from the past. Given time it will change. What human kind is biologically hardwired for is personal survival ability, not leaving the world for youngsters as soon as possible, and those two precepts are mutually exclusive.

Humans have individually weak survival instincts, which is why soldiers were running into machine gun fire on the beaches of Normandy (or why others ride motorcycles). Some of that is surely the denial of our own mortality.

Humans excel at surviving as a group, which is a very different - sometimes contrasting - thing.

Re: Longevity FAQ: A beginner's guide to longevity research

#98
post #59

In 1897, philosopher Paul Janet came up with the model that current moments of time in our lives might be perceived by their "fraction of life lived thus far". This would seem to undermine the value of longevity somewhat: according to this visualization of the idea: https://www.maximiliankiener.com/digitalprojects/time/

I'm inclined to think that this sort of thing is partly driven by something like Stockholm syndrome, because trying to convince yourself having a shorter life is okay is easier than actually extending it.

Re: Longevity FAQ: A beginner's guide to longevity research

#99

Actual substantial longevity - beyond quality of life enhancements - is something I greatly fear. It would change everything. Imagine life with no kids and the joy they bring, a stagnation in all societal structures, no turnover of ideas (loosely quoting "agendas don't die; people die"). I'm sure such a civilization would be very stable, but won't have any extreme sports.

I don't know why you got down voted. Its perfectly honest to express what you feel.

Re: Longevity FAQ: A beginner's guide to longevity research

#100
post #90

I stopped reading after seeing the cancer/hearth disease chart. It reinforces the belief that most deaths are caused by cancer, while actually it's hearth disease. So if you make a chart, please make it accurate. Therefore I couldn't trust the rest, since it might all be "drawn from the wrist".

If you unify all cancers into one category, then cancer is the top cause. If you split them up into the different types, then heart disease is bigger than any single of them. So you are wrong. https://www.who.int/news-room/fact-sheets/detail/the-top-10-... Shows heart disease as #1 with 3 million deaths but separates the cancer types. https://www.who.int/news-room/fact-sheets/detail/cancer Says there were 9.6 million…

In that case, heart disease should be split too. It isn't as many things as cancer, but it isn't all one thing, either.
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