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Estimating unobserved SARS-CoV-2 infections in the United States

pnas.org

21–30 of 73 posts

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#21
post #6

Earlier quoted context omitted.

I had wondered how the current new cases / day in NY were so low as compared to other areas. This seems likely to be at least part of it. What's the theory on why other places that were hit hard early are still quite high...like California? Lower density?

California wasn't hit very hard early. In terms of total reported cases, they're only just now starting to catch up with New York (21 per thousand for the state vs 17 per thousand for California) - and as we catch up we've had a pretty sharp improvement from the peak in July. The theory is that California flattened the curve in the original sense, delaying the peak in order to ensure it's moderately lower and protect…

I’m sure overall prevalence in CA has a ways to go to catch up to NY (NY “cases” is a massive undercount compared to CA’s moderate undercount) but they’ll get there soon enough.

The takeaway to me is that unless you are willing to exert extremely strict border controls, localized quarantines and hard lockdowns of hotspots, and pervasive test & trace, indefinitely, then you wont keep Rt below 1 without the benefit of some herd immunity.

Hence lockdowns should either be as minimal as possible, encouraging low-risk populations to be out and about while high-risk populations shelter.... Or, you need an extreme and extraordinary response until widespread effective vaccination.

Small island nations may find they can choose the second path (although it’s not guaranteed, Hawaii has recently failed at it) but the vast majority of the world should choose the first.

And we should stop politicizing it, because largely everyone is in the same boat and will hit all the same endpoints.

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#22
post #10

Earlier quoted context omitted.

Louisiana, then?

I don't know enough about Louisiana to offer more than the calculation that they've indeed seen more reported cases per capita than New York.

Seems that at least for cases on a per-capita basis, LA got it worse than CA during both humps:

http://91-divoc.com/pages/covid-visualization/?chart=states-...

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#23

Earlier quoted context omitted.

As nice as it would be, seroprevalence studies have ruled out the "basically everyone in New York caught it" theory.

T-cell immunity is known to be a relevant factor, though. It'd be unreasonable to assume it fully plugs the gap, but I think there's gotta be some explanation for why only areas hit hard in April were able to keep cases low over the last few months.

Because the population has been more cautious since then?

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#24
post #9

Earlier quoted context omitted.

I don't know a single person in NY who wasn't coughing for a week at some point between january and march.

In the last few days of January and two weeks in early February in Manhattan, I (26M) got quite sick. The first few days were pretty bad and I had 102F fever. I had lots of difficulty breathing and a dry cough for around 2 weeks after. A friend/co-worker who sits next to me at work had essentially identical symptoms 12 hours before me lasting for similar amount of time. I think his breathing problems were less bad th…

Get an IgG antibody test if you want to know, should still be visible there

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#25
post #23

Earlier quoted context omitted.

T-cell immunity is known to be a relevant factor, though. It'd be unreasonable to assume it fully plugs the gap, but I think there's gotta be some explanation for why only areas hit hard in April were able to keep cases low over the last few months.

Because the population has been more cautious since then?

There's nothing like seeing your friends and family struggling to breath to keep you being careful.

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#26
post #5

I seem to be hitting trying to read this. Can someone help summarize the results of this analysis?

The core result is > Simulating from 1 January, we obtained 108,689 (95% PPI: 1,023 to 14,182,310) local infections cumulatively in the United States by 12 March (Fig. 1A). What that means is that they don't really know - that confidence interval is absurd - but they have reason to think there could have been 100k Americans with the coronavirus on March 12.

Results with such confidence intervals should not be allowed to be published.

As if we don't have enough fake news/hype going around.

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#27
post #17

Earlier quoted context omitted.

As nice as it would be, seroprevalence studies have ruled out the "basically everyone in New York caught it" theory.

It’s statistically impossible for literally everyone in NY to catch COVID. What recent studies have shown is that while the naive herd immunity threshold is perhaps around 60% (working backwards from R0 estimates), after you factor in clustering of populations, baseline hygienic improvements, and moderate social distancing, that NY did reach an effective level of herd immunity.

I hope so. We'll find out either way.

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#29

Interesting. An estimate that infections were multiple orders of magnitude higher than detected in mid-March is higher than I'd heard before, although I suppose it's probably implied by the "basically everyone in New York caught it" theory.

I don't know a single person in NY who wasn't coughing for a week at some point between january and march.

Is it possible that your NY social network at the time was part of a fairly insular clique?

That might explain why your sample is (potentially) not representative of the overall city or state.

Re: Estimating unobserved SARS-CoV-2 infections in the United States

#30
post #24
post #9

Earlier quoted context omitted.

In the last few days of January and two weeks in early February in Manhattan, I (26M) got quite sick. The first few days were pretty bad and I had 102F fever. I had lots of difficulty breathing and a dry cough for around 2 weeks after. A friend/co-worker who sits next to me at work had essentially identical symptoms 12 hours before me lasting for similar amount of time. I think his breathing problems were less bad th…

Get an IgG antibody test if you want to know, should still be visible there

It isn’t a fully reliable test though. There are both false positives and false negatives.
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