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Nasal vaccine against Covid-19 prevents infection in mice

medicine.wustl.edu

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Re: Nasal vaccine against Covid-19 prevents infection in mice

#11

Post by solinent »

disclaimer: use distilled water or salt water or you could get a severe infection. You can buy this from the pharmacy, and HydraSense sells it pre-packaged in a spray format.

I've been using a nasal rinse since covid started, since it was mentioned by an infectious disesases professor (I forget his name now) that it starts in the nose and if you manage to swallow it into your stomach you'll be okay--it's only if you can't swallow the mucus caught up in your ENT system that it travels to the lungs.

Since I've always had sinus problems this is something I've had to do occasionally anyways.

edit: Michael Osterholm, a regents professor in epidemiology.

edit2: If you're not willing to do a nasal rinse, just gargle with water, I believe that should help as well.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#12

Post by gvjddbnvdrbv »

corty wrote: post #7
user_501238901 wrote: post #5

I'm very interesting if we switched to using nasal vaccines, would it help soothe out the rabid anti-vaxxers? A large part of the movement IMO stems from the fact that subconsciously, humans tend to associate long sharp needles = pain = bad

Polio is available as an oral vaccine that used to be widespread in the west. I still remember demanding a sugarcube with every oral medication after getting one for the polio vaccination :) That doesn't seem to stop anti-vaxxers: https://www.latimes.com/world-nation/story/2019-09-04/anti-v...

The oral polio vaccine is a live vaccine. It is much more effective than the injected dead vaccine we now get in the west but it does occasionally cause polio outbreaks...

Re: Nasal vaccine against Covid-19 prevents infection in mice

#13

Post by jbd28 »

solinent wrote: post #11

disclaimer: use distilled water or salt water or you could get a severe infection. You can buy this from the pharmacy, and HydraSense sells it pre-packaged in a spray format. I've been using a nasal rinse since covid started, since it was mentioned by an infectious disesases professor (I forget his name now) that it starts in the nose and if you manage to swallow it into your stomach you'll be okay--it's only if you…

That viral email was complete junk from early in the pandemic

Re: Nasal vaccine against Covid-19 prevents infection in mice

#14

Post by nO0b »

solinent wrote: post #11

disclaimer: use distilled water or salt water or you could get a severe infection. You can buy this from the pharmacy, and HydraSense sells it pre-packaged in a spray format. I've been using a nasal rinse since covid started, since it was mentioned by an infectious disesases professor (I forget his name now) that it starts in the nose and if you manage to swallow it into your stomach you'll be okay--it's only if you…

It's worth mentioning that nasal rinses without proper precautions can be extremely dangerous, and even fatal.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#15

Post by solinent »

jbd28 wrote: post #13
solinent wrote: post #11

disclaimer: use distilled water or salt water or you could get a severe infection. You can buy this from the pharmacy, and HydraSense sells it pre-packaged in a spray format. I've been using a nasal rinse since covid started, since it was mentioned by an infectious disesases professor (I forget his name now) that it starts in the nose and if you manage to swallow it into your stomach you'll be okay--it's only if you…

That viral email was complete junk from early in the pandemic

It wasn't a viral email--it was a one hour podcast on Youtube. I can post a link if you'd like.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#16

Post by solinent »

nO0b wrote: post #14
solinent wrote: post #11

disclaimer: use distilled water or salt water or you could get a severe infection. You can buy this from the pharmacy, and HydraSense sells it pre-packaged in a spray format. I've been using a nasal rinse since covid started, since it was mentioned by an infectious disesases professor (I forget his name now) that it starts in the nose and if you manage to swallow it into your stomach you'll be okay--it's only if you…

It's worth mentioning that nasal rinses without proper precautions can be extremely dangerous, and even fatal.

Not really fatal, there are many products you can use that don't require a full rinse. Have a source for that? I can't find anything.

It's important not to do it too frequently, but certainly more than 1 billion people do it every day I'm sure.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#17

Post by rzimmerman »

solinent wrote: post #16
nO0b wrote: post #14

Earlier quoted context omitted.

It's worth mentioning that nasal rinses without proper precautions can be extremely dangerous, and even fatal.

Not really fatal, there are many products you can use that don't require a full rinse. Have a source for that? I can't find anything. It's important not to do it too frequently, but certainly more than 1 billion people do it every day I'm sure.

I think they’re referring to the risk of microorganisms in tap water which, when present in a sinus rinse/neti pot can cause illness or be fatal: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html

People should be using distilled water or at least a proper filter when doing a sinus rinse.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#18

Post by Duller-Finite »

This is an interesting and well-done paper. It is, however, difficult to evaluate these mouse studies because, unlike human ACE2, mouse ACE2 doesn't facilitate SARS-CoV-2 cell entry. Therefore, they had to first deliver hACE2 either with an intranasal adenovirus injection, or use transgenic mice expressing hACE2 in a pattern that does not recapitulate its expression in humans.

It does seem like they do an especially good job at blocking infections in the respiratory system, but that's both the system that they primed for infection and where they provided the ChAd vaccine, so I don't know how fair of a comparison the intramuscular injection experiments are.

Re: Nasal vaccine against Covid-19 prevents infection in mice

#19

Post by solinent »

rzimmerman wrote: post #17
solinent wrote: post #16

Earlier quoted context omitted.

Not really fatal, there are many products you can use that don't require a full rinse. Have a source for that? I can't find anything. It's important not to do it too frequently, but certainly more than 1 billion people do it every day I'm sure.

I think they’re referring to the risk of microorganisms in tap water which, when present in a sinus rinse/neti pot can cause illness or be fatal: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html People should be using distilled water or at least a proper filter when doing a sinus rinse.

Yeah, definitely use salt water. I will mention that in the main post. You can get a product like the following which has a water preparation which should be safe:

https://www.hydrasense.com/

Re: Nasal vaccine against Covid-19 prevents infection in mice

#20

Post by rzimmerman »

solinent wrote: post #19
rzimmerman wrote: post #17

Earlier quoted context omitted.

I think they’re referring to the risk of microorganisms in tap water which, when present in a sinus rinse/neti pot can cause illness or be fatal: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html People should be using distilled water or at least a proper filter when doing a sinus rinse.

Yeah, definitely use salt water. I will mention that in the main post. You can get a product like the following which has a water preparation which should be safe: https://www.hydrasense.com/

Most of these products have a salt packet (you’re right - you definitely should not use fresh water - it will very likely cause damage) but you still need to start with distilled or properly filtered water.
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