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A CRISPR first produces squid as clear as glass

nature.com

61–70 of 71 posts

Re: A CRISPR first produces squid as clear as glass

#61

As a learner, is it possible to self learn more about Gene Editing and these things, and can these things can be learned in a hacker way without going through a formal academic route ?

You can take an at-home course from the-odin.com. Their kits are useful and their youtube videos are too (though they can be a bit slow).

Re: A CRISPR first produces squid as clear as glass

#62

As a learner, is it possible to self learn more about Gene Editing and these things, and can these things can be learned in a hacker way without going through a formal academic route ?

I don't mean to sound pointed, as these links may seem, but honestly just reading the wikis for genetic engineering and genome editing is a viable way to learn more in my opinion. Just make sure to remain in the general sections and click the hyperlinks of unfamiliar topics, and venture into the weeds of the topics once you begin to feel comfortable with the jargon. https://en.wikipedia.org/wiki/Genome_editing https://en.wikipedia.org/wiki/Genetic_engineering

Re: A CRISPR first produces squid as clear as glass

#63
post #27

I feel creeped out/put off about this. These are intelligent beings, apparently limited only by their short lifespan. They communicate by modulating the pigments into patterns. Now that has been taken away. Imagine toasting some genes in a human embryo to the effect of lock in syndrome. Crispy! edit: I think this is a case for PETA to look into.

Cephalopods are amazing animals but I would be careful about anthropomorphizing their behavior. If they are communicating via chromatophores, then this type of animal model will be key to understanding how this kind of signalling works. Cruelty implies stress or pain; albino social animals might be a better analogy than lock in syndrome.

Probably mute(ness) would be most fitting.

Feels wrong to me, any way.

Re: A CRISPR first produces squid as clear as glass

#64
post #5

Earlier quoted context omitted.

And the advantage here is that it's the start of development of a genetic-modification toolkit (similar to that we already have for fruit flies and c elegans and zebrafish) for using them as animal models. Much more complex of a brain than any of the other animal models we usually use.

Isn't this a bit of a slippery slope? The better a model of a human brain you experiment on, the closer you approach the ethics of performing the same experiment on human embryos, infants, children, and adults (as they age). I think this is already pretty close to the case for mice, but when you start doing it to cephalopods, primates, and dolphins/orcas, you're really skirting the line. I wonder if there'll ever be…

Wait until you read about pig intelligence levels. And unfortunately, it seems I still love ham and bacon :-(

Re: A CRISPR first produces squid as clear as glass

#65
post #14

I feel creeped out/put off about this. These are intelligent beings, apparently limited only by their short lifespan. They communicate by modulating the pigments into patterns. Now that has been taken away. Imagine toasting some genes in a human embryo to the effect of lock in syndrome. Crispy! edit: I think this is a case for PETA to look into.

That's octopodes; squid are much less intelligent. They're moving on next to much smaller (and hence even less intelligent) hummingbird bobtail squid.

The big squids are probably much more intelligent than octopus.

Octopuses are solitary. Squids are social and top predators able to travel very long distances and live in a wider range of habitats. They can make light and use light and color patterns to display complex behaviour or lure preys

Is also well known that squids are able to communicate two opposite messages to different colleagues at the same time.

Re: A CRISPR first produces squid as clear as glass

#66

Earlier quoted context omitted.

Youtube is fantastic for this. What you'll find out is that once you understand how DNA works (codons map to amino acids), and that amino acids fold into specific 4D shapes that trap molecule A and mush it into molecule B to make molecule C, the rest kind of falls into place.

Haha, as a Biochemistry PhD student, this is almost exactly how I will often break down biology to a layperson: DNA corresponds to proteins that are essentially just shapes bumping into other shapes, sometimes making new shapes and sometimes destroying them in the process. Of course, provided 4 billion years of evolution, this has yielded staggering complexities, but at the heart of it is just globs.

"Given enough time, Hydrogen starts to wonder where it came from, and where its going."

Re: A CRISPR first produces squid as clear as glass

#67

Earlier quoted context omitted.

Youtube is fantastic for this. What you'll find out is that once you understand how DNA works (codons map to amino acids), and that amino acids fold into specific 4D shapes that trap molecule A and mush it into molecule B to make molecule C, the rest kind of falls into place.

4D shapes as in changing over time?

Yes, exactly. It's really quite fascinating--everything just vibrates, like a lot, all the time. The vibrations of some bits have frequencies that resonate with the frequency of other bits. And when they sync up, they change their frequency and then no longer resonate with each other. The whole universe is basically a giant musical instrument and chemical reactions are just wavelettes resonating with other things.

Re: A CRISPR first produces squid as clear as glass

#69
post #55
post #54

Earlier quoted context omitted.

Is there a specific disease you're targeting, or are you trying to give general humans abilities they don't already have? The latter is not being considered at this point.

It's both. No human has the ability to synthesize vitamin C in their own bodies, leading to scurvy, unless you supplement vitamin C in your diet. Most people eat enough vitamin C to not lead to scurvy. There is a disease that would be eliminated, but it's preventable by watching out what you eat. Also, usually it takes more than just the synthesis of the enzyme. It also needs to be regulated, which requires the syste…

> No human has the ability to synthesize vitamin C in their own bodies, leading to scurvy, unless you supplement vitamin C in your diet. This is a disease that would be eliminated

We could fall in the opposite situation easily, excess of vitamin C (from our body plus the same amount as before in the diet), leading to a scenery of nausea, vomit, headache and diarrhea, maybe permanent.

Re: A CRISPR first produces squid as clear as glass

#70
post #57

Earlier quoted context omitted.

Isn't this a bit of a slippery slope? The better a model of a human brain you experiment on, the closer you approach the ethics of performing the same experiment on human embryos, infants, children, and adults (as they age). I think this is already pretty close to the case for mice, but when you start doing it to cephalopods, primates, and dolphins/orcas, you're really skirting the line. I wonder if there'll ever be…

We're still chopping up likely-sentient animals and eating them, so it's probably a ways off..

Indeed. But many experiments are more cruel to sentient beings than, say, getting shot by a hunter. I'd much prefer to be summarily executed than to end up in Mengele's lab. Both are wrong, but one is worse.
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