Are its eyes messed up in the photo or is that normal?
Yeah it really looks like the eye pigments are not the same.
They aren't, and the article notes as much.
A CRISPR first produces squid as clear as glass
31–40 of 71 posts
Re: A CRISPR first produces squid as clear as glass
#32Could this have been done on an adult squid??
Re: A CRISPR first produces squid as clear as glass
#33So we're getting closer to RayFish Footwear https://www.rayfish.com/ - https://www.youtube.com/watch?v=gVk_Vw1C7cs
Re: A CRISPR first produces squid as clear as glass
#34Could this have been done on an adult squid??
I assume not. I am pretty confidnet the whole purpose is for the cells to never grow.
It works by editing cell information. If you let original cells divide there will be more unedited cells. So the eariler in the development you apply modification the more prononuced the effect. I think I read somewhere that they could alter amount of pigmentation by timing application of treatment. So that would fit.
It doesnt work by killing existing cells. Maybe it could work if old cells died and new ones would be edited, so they could gradually replace original ones but I guess its pretty hard to deliver gene editor to so many cells.
Re: A CRISPR first produces squid as clear as glass
#35For anyone coming to the comments before reading the article: the squid is already clear, they just removed some spots of pigment.
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Re: A CRISPR first produces squid as clear as glass
#36Could this have been done on an adult squid??
I assume not. I am pretty confidnet the whole purpose is for the cells to never grow. It works by editing cell information. If you let original cells divide there will be more unedited cells. So the eariler in the development you apply modification the more prononuced the effect. I think I read somewhere that they could alter amount of pigmentation by timing application of treatment. So that would fit. It doesnt work…
Cells divide really slowly so if you could edit most cells in one day then only a negligible amount of new cells would be unedited.
* I guess its pretty hard to deliver gene editor to so many cells* this is the breakthrough waiting CRISPR and impossible to find a great up to date scientific resource on the technical issues and on the path towards progress.
Re: A CRISPR first produces squid as clear as glass
#37Ira Flatow interviews two of the scientists on a Science Friday podcast:
Re: A CRISPR first produces squid as clear as glass
#38Read Sheena 5 by Stephen Baxter, great short story.
Re: A CRISPR first produces squid as clear as glass
#39Ira Flatow interviews two of the scientists on a Science Friday podcast: https://www.sciencefriday.com/segments/squid-gene-editing/
This is a great 17 minute high-level overview of the science. The breakthrough is the tool/technique used to access the embryo without physically damaging the egg. The glass-like embryo is a unique characteristic of this species, not the knockout gene. This work is a proof of concept; this species does not (yet) reproduce in captivity. Both scientists demonstrate a deep love for cephalopods and for science. They also discuss the ethics surrounding cephalopod research.
Re: A CRISPR first produces squid as clear as glass
#40Earlier quoted context omitted.
In my country (France) the use of CRISPR is highly regulated (its basically regulated as biological weapon material). You could learn about it from articles and textbooks but are very unlikely to be able to play with it.
As much as I appreciate the desire for governments to stem the tide, what you're saying is likely very difficult--if not impossible--for a government to effectively stop. Of course, people who don't want to break the law will comply but those who don't care will have no trouble doing as they please. Gene editing is quite simple now, and with only a few purchased parts one can edit whatever they please. Maybe you're t…
Is editing human embryos harder? Or how is it less difficult for a government to stop?