Drama and politics variously meant that I had to accept requests from people who posted far too many meaningless status updates. Blocking, hiding, muting etc. don't work when you need to respond to 1 out of the 100 posts they send your way.
If it was possible to filter, mute, mark-as-read on a programmatic basis as it is with email (Love gmail filters...), I might not have been forced to delete my account.
People can't take it personally when you delete your account, but not friending, unfriending, hiding, or blocking can all be considered personally offensive actions.