Earlier quoted context omitted.
AFAIK the ME is required to initialize the processor so it can never be completely disabled. The best you could do is remove any code beyond necessary initialization which has mostly already been done by me_cleaner.
How easy is it to use me_cleaner? Last time I looked it required some wiring and a Raspberry Pi.
It took me about 10 minutes to do my ThinkPad. All I lost was some enhanced integrated GPU power management and integrated thermal management, but I use a userland fan control program anyhow.