Earlier quoted context omitted.
That put that in a pitch deck and go get some funding.
Might run into severe ego issues blocking doctors from using such service, but probably not enough to make it infeasible.
Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
61–70 of 73 posts
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#62Earlier quoted context omitted.
I don't know how doctors would feel but maybe it's time to have a system to query more than one doctor for patient's ailments. Instead of waiting to run into the occasional pro that actually knows your issue and fix it with a switch. No need for moonshot AI just an large aggregative system that let's curious doctor that are very capable in a subfield scan open issues for diagnosis.
The Human Diagnosis Project (YC S12) is something like this. You can see a sample of the cases on their Twitter: https://twitter.com/hdx
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#63Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#64The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…
"One study of 28 subjects looked specifically at whether psyllium husk plays a role in patients with irritable bowel syndrome, discovering that psyllium husk eliminated symptoms"
https://selfhacked.com/blog/psyllium-husk/ https://selfhacked.com/blog/irritable-bowel-syndrome/
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#65Earlier quoted context omitted.
Would you mind disclosing who the doctor was? I have been dealing with this for years and it's been wreaking havoc on my personal and professional lives. Doctors in my area are not familiar with my condition and don't have a solution. I'm especially tired of the malabsorption, dietary restrictions, sleeping issues, inability to gain weight, edema.. a whole laundry list. Would love to hear your doctor's opinion. I am…
I had similar experiences, but with amitriptyline at the lowest dose of 10mg taken every night. At 25mg I was too drowsy. It drastically improved all of my chronic problems almost immediately - gut problems (IBS-D), inability to sleep more than a few hours, and issues with peripheral nerves. Amitriptyline has a slight sedative effect compared to nortriptyline, which is good if you suffer problems with sleep, but has…
My GPs seem to think I am insane and that this is all induced by "stress and anxiety" since my bloodwork is for the most part normal—although in the past months it's been teetering on the verge of becoming problematic in some areas. Because of this, they write most of my symptoms off.
Was there something that you said specifically that caused them to prescribe that or it was just after describing your symptoms? I feel like if I go in saying "well I read about this SSRI on the internet"... instead the psych ward is going to be their next prescription for me.
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#66Earlier quoted context omitted.
The key to a good diet is balance. Too much red meat has equally severe health implications, leading to a higher risk for heart disease, cancer, diabetes, and premature death.[1][2] [1] https://www.health.harvard.edu/staying-healthy/whats-the-bee... [2] https://pubmed.ncbi.nlm.nih.gov/26780279/
Mankind evolved to eat red meat. We developed fire for it. We invented spears and bow hunting for it. It's one of the healthiest foods you can consume, has been part of the human diet for over 2 million years... and besides the noted protein, it contains B12, Zinc, Selenium, Iron, Niacin, B6, Phosphorous and many other valuable nutrients. You can live exclusively off a diet of just red meat and live a long, healthy l…
The Inuit don't eat the way they used to, but it was a good deal of fish along with game and berries (ditto for Sami). Their CVD profile has never been reported to be particularly good. Maasai consume mostly milk, and are in a perpetual state of caloric deficit.
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#67The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#68About 30 - 60 mins after eating (anything), in addition to bloating and discomfort, I feel the most extremely incapacitating lows. We are talking what I can only assume a depressive episode feels like.
Its like a wave comes over me, I have no joy in my head, no passion, no desire for communication, I simply have to wait for it to pass, and eventually it does, and I feel normal again in a few hours. There is nothing I can do to make it pass earlier. Its as if the food's passage is causing it.
I don't have a eating disorder, ie I like food and comfortable with my body, but really struggle with this. If anyone has had any thing similar I would be very interested in communicating more.
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#69Earlier quoted context omitted.
I had similar experiences, but with amitriptyline at the lowest dose of 10mg taken every night. At 25mg I was too drowsy. It drastically improved all of my chronic problems almost immediately - gut problems (IBS-D), inability to sleep more than a few hours, and issues with peripheral nerves. Amitriptyline has a slight sedative effect compared to nortriptyline, which is good if you suffer problems with sleep, but has…
Wow that's so interesting. What problems were you experiencing with peripheral nerves? I have also developed these problems recently. I had a colonoscopy where I had to chug a bunch of polyethylene glycol and after that I've had fluctuating levels of numbness (peripheral neuropahy? I am assuming) in both of my hands. I have no idea the pathology here.. electrolyte problems? Docs aren't even investigating. My GPs seem…
It seems that the flare-ups heighten pain sensitivity in the peripheral nerves in addition to the gut problems. My whole body feels 'raw' when it happens.
I have no idea on what the pathology is, but I expect it has a genetic component. It seems that my gut has issues with the self-regulation of certain neurotransmitters.
Over the past decade or more, I've tried nearly all of the other treatments for IBS and none of them work. The peppermint oil capsules were the worse. It was a complete waste of time and you walk around with the smell of toothpaste, at least that's how it felt to me.
You can refer back to some credible information for patients like this here from the NHS -
https://www.nhs.uk/conditions/irritable-bowel-syndrome-ibs/f...
Amitriptyline is clearly a treatment option for IBS there. Insist on it and your doctor should have no reason to deny it to you unless you have a contraindication.
If you're not in the UK, then there are other sources like this -
https://www.mayoclinic.org/medical-professionals/digestive-d...
Key takeaway from that article -
>In one trial, nearly 70 percent of patients receiving 10 mg of amitriptyline experienced a complete loss of IBS symptoms compared with 28 percent of those on placebo.
I guess I'm lucky and in that 70%. I hope you are as well. It's such a big effect on my health, I wish I knew how to deal with it sooner.
Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System
#70Earlier quoted context omitted.
Wow that's so interesting. What problems were you experiencing with peripheral nerves? I have also developed these problems recently. I had a colonoscopy where I had to chug a bunch of polyethylene glycol and after that I've had fluctuating levels of numbness (peripheral neuropahy? I am assuming) in both of my hands. I have no idea the pathology here.. electrolyte problems? Docs aren't even investigating. My GPs seem…
I had those same issues with first numbness, then progressing to sore joints, in the fingers and toes. Then it progressed to sore joints around the body. It seems that the flare-ups heighten pain sensitivity in the peripheral nerves in addition to the gut problems. My whole body feels 'raw' when it happens. I have no idea on what the pathology is, but I expect it has a genetic component. It seems that my gut has issu…
Anyways thank you so much. I will run this buy them and see what they say. Now I have a new path to explore and some new found hope as my options were running out.