Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System • Hacker News Board

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#41

Post by james_s_tayler » Mon, Aug 03, 2020, 9:39 AM UTC

agumonkey wrote: post #39

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

I don't know how doctors would feel but maybe it's time to have a system to query more than one doctor for patient's ailments. Instead of waiting to run into the occasional pro that actually knows your issue and fix it with a switch. No need for moonshot AI just an large aggregative system that let's curious doctor that are very capable in a subfield scan open issues for diagnosis.

That put that in a pitch deck and go get some funding.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#42

Post by fodmap » Mon, Aug 03, 2020, 9:42 AM UTC

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

Are you completely free from IBS (that would be a dream come true for me) or are you still suffering recurrent bursts?

I'm still fighting my way out of it. The Low FODMAP diet is helping me, and I have an eye on hypnotherapy as my next step. See https://lens.monash.edu/@medicine-health/2019/06/24/1351605/...

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#43

Post by ElKrist » Mon, Aug 03, 2020, 10:05 AM UTC

fodmap wrote: post #42

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

Are you completely free from IBS (that would be a dream come true for me) or are you still suffering recurrent bursts? I'm still fighting my way out of it. The Low FODMAP diet is helping me, and I have an eye on hypnotherapy as my next step. See https://lens.monash.edu/@medicine-health/2019/06/24/1351605/...

Have you identified which fodmap group you're sensitive to? My girlfiend is a professional dietician, is suffering from IBS and has found a pill containing an enzyme that she swallows before eating a certain fodmap group. It helped her a lot.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#44

Post by globular-toast » Mon, Aug 03, 2020, 10:20 AM UTC

amelius wrote: post #12

PragmaticPulp wrote: post #6

Earlier quoted context omitted.

Interesting. Every time I go low-carb, I loose my taste for sweets in about 3 weeks. Anything sugary starts to taste bad until I re-acclimate to it.

It's a pity there aren't many foods with a sugar level that tastes well to people who aren't acclimated to eating sugary things. The food industry has decided it's either no sugar or lots of sugar, so it seems.

Make it yourself. Make all of your food yourself. My regular gym routine, which was part of my life for years until a few months ago when I was forced to stop, involved lifting heavy weights followed shortly afterwards by a bowl of porridge. It's a big bowl of porridge and I would put about 2 tsp of sugar in it to sweeten it. I considered this sweet because it was, in fact, the only sugar I was consuming. Now since lockdown I've had to stop my porridge because my muscle was becoming replaced with fat. I've had to lose weight to stay lean. But I've replaced that small amount of sugar I had regularly with other sweet things and noticed that I'm consuming far more sugar now. I've decided to stop completely now. If you consume ready-made things with sugar, it very quickly becomes an addiction.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#45

Post by fodmap » Mon, Aug 03, 2020, 10:34 AM UTC

ElKrist wrote: post #43

fodmap wrote: post #42

Earlier quoted context omitted.

Are you completely free from IBS (that would be a dream come true for me) or are you still suffering recurrent bursts? I'm still fighting my way out of it. The Low FODMAP diet is helping me, and I have an eye on hypnotherapy as my next step. See https://lens.monash.edu/@medicine-health/2019/06/24/1351605/...

Have you identified which fodmap group you're sensitive to? My girlfiend is a professional dietician, is suffering from IBS and has found a pill containing an enzyme that she swallows before eating a certain fodmap group. It helped her a lot.

Thank you for your comment.

Is your girlfriend sensitive to galacto-oligosaccharides (GOS)? I know there this enzyme therapy for that problem https://www.monashfodmap.com/blog/new-research-enzyme-therap... but I haven't try it.

I'm sensitive to some GOS but I haven't being professionally tested for them. I did a fructose malabsorption test though, and I tested positive.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#46

Post by tuukkah » Mon, Aug 03, 2020, 10:43 AM UTC

chrisco255 wrote: post #29

pfundstein wrote: post #28

Earlier quoted context omitted.

>IIRC living into the 40s or 50s was typical for an early human that survived to adulthood. >60s or 70s not uncommon. I would love to see the evidence you're referencing. > Life expectancy being 25 doesn't mean nobody lives past 25. You're absolutely right.

We can't actually tell the age of death of human fossils past the time that wisdom teeth grow in. There's no way of telling whether a fossilized skeleton was 30 at death or 50 at death. Even then, we don't necessarily have a representative sample. The Sami, as I mentioned, have been studied. They are a tribe of reindeer herders in northern Scandinavia. They eat a diet consisting of almost exclusively reindeer meat. T…

> They eat a diet consisting of almost exclusively reindeer meat.

Very far from a typical meat diet (quoting from your link):

"The dietary habits of the Sami differ from those of the other Finns. Reindeer meat (low in fat) and fish have been important foodstuffs in the diet of Sami people. Intake of vegetables and fresh fruits has been low, but berries were eaten, especially by the North Sami. Although nowadays dietary habits have become more similar to that of the rest of the population, still more than 90% of male Sami reindeer herders eat reindeer meat at least 3 times a week and almost 50% eat fish at least twice a week. Reindeer meat and fish contain high concentrations of healthy lipids, trace elements (e.g., selenium), minerals and vitamins. Arctic people usually rely on blood, liver or kidneys from animals to obtain adequate nutrition."

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#47

Post by dillonmckay » Mon, Aug 03, 2020, 11:43 AM UTC

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

The gut is a second brain, kinda...I have always been fascinated by this book:

The Second Brain

https://www.amazon.com/Second-Brain-Groundbreaking-Understan...

Author is Michael D. Gershon M.D., chairman of the Department of Anatomy and Cell Biology at Columbia University's College of Physicians and Surgeons at the Columbia-Presbyterian Medical Center in New York City.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#48

Post by dillonmckay » Mon, Aug 03, 2020, 11:45 AM UTC

FreeFull wrote: post #38

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

The gut has its own nervous system: https://en.wikipedia.org/wiki/Enteric_nervous_system . Usually the effects of antidepressants on the gut are considered an unwanted side-effect, but in your case it was the intended effect.

The Second Brain, according to Michael D. Gershon M.D.

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#49

Post by ElKrist » Mon, Aug 03, 2020, 11:53 AM UTC

fodmap wrote: post #45

ElKrist wrote: post #43

Earlier quoted context omitted.

Have you identified which fodmap group you're sensitive to? My girlfiend is a professional dietician, is suffering from IBS and has found a pill containing an enzyme that she swallows before eating a certain fodmap group. It helped her a lot.

Thank you for your comment. Is your girlfriend sensitive to galacto-oligosaccharides (GOS)? I know there this enzyme therapy for that problem https://www.monashfodmap.com/blog/new-research-enzyme-therap... but I haven't try it. I'm sensitive to some GOS but I haven't being professionally tested for them. I did a fructose malabsorption test though, and I tested positive.

Yes she reckons the enzyme works both for FOS and GOS. Things like onions and garlic were an absolute no-go before she found the enzyme. Now she can eat them

She has to take an enzyme pill before each meal that includes this group though. It's fairly harmless so she doesn't mind, it's just a bit of additional cost on our food.

If you're motivated, you can follow a protocol ("food challenges") to know which group(s) you're sensitive to. The idea is that you have a zero fodmap diet for a few weeks and then slowly reintroduce small amounts from each group and see how you react. It is not an easy task to figure out meals this way and to keep motivation so I'd recommend being helped by a dietician.

To the best of my gf's knowledge, there is no such enzyme for fructose intolerance unfortunately.

Also, if you want to know more about each group and which food is the most problematic in each of them, Monash has a great app for that. You've probably come across it already, otherwise search "Monash fodmap" on your app store. It's great to know if you can have a little bit of something or nothing at all and to educate yourself

Re: Brain-Gut Circuit Lets Microbiota Directly Affect the Sympathetic Nervous System

#50

Post by 1_player » Mon, Aug 03, 2020, 12:00 PM UTC

Vaslo wrote: post #15

The brain gut connection is incredible. For years I suffered with terrible IBS where I would almost always get nauseous after eating and would often need to immediately go to the bathroom. I also had a very difficult time gaining weight. I tried all kinds of drugs - prescriptions to treat nausea, malabsorption, even gastroparesis (slow emptying of the stomach). Nothing worked and a few of the prescriptions were nerve…

I have the exact same problem and symptoms and my cheap solution to completely and radically change diets fixed my IBS and lifelong mood disturbances in a week. It's so good that this weekend I had a "bad food" binge and I've spent 5 hours on the toilet and the whole weekend in a sorry state of mind.

I can't wait for the day until GPs will try and diagnose digestive and psychological issues with dietary changes that are not just "eat whole grains, plenty greens and less meat" which completely miss the mark.