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Glucosamine Supplementation Reduces All-Cause Mortality: Study

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Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#21

Post by tboughen »

sroussey wrote: post #16
clairity wrote: post #14

Earlier quoted context omitted.

there's no reason to believe macromolecules like glucosamine benefit the body any more than regular, nutritious food. ingested nutrition generally gets broken down into amino acids and the like in the digestive system before it gets distributed to the rest of the body to be reconsistuted into cells and tissue. cartilage in particular is scaffolding and generally must be constructed by other cells from very basic mole…

As someone that has taken various vitamins and supplements over the years, glucosamine is the one where I truly feel a difference. In my knees, my back stopped cracking when I woke up, and generally just better. Others I take based on blood tests if something is out of whack for a time.

Can I ask your age (or which decade if you prefer!)?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#22

Post by polynomial »

brownbat wrote: post #12
throw1234651234 wrote: post #4

Earlier quoted context omitted.

I am guessing they didn't control for lifestyle, etc. Someone who takes glucosamine either works out heavily and supplements (and probably watches their diet), or had joint surgery, and falls into the first group to some degree. Edit: Yea, reading the study, I don't see anything about controlling for fitness level. Running and caring about one's diet alone would account for this effect without glucosamine.

> Edit: Yea, reading the study, I don't see anything about controlling for fitness level. They specifically control for the following lifestyle factors: "smoking status, alcohol consumption, physical activity, body mass index (BMI) and vegetable and fruit consumption." (Ctrl+f for "covariates") In the conclusion, they acknowledge: "Although we had carefully adjusted for potential confounding lifestyle-related factors…

I don't see "other supplements" in that list; surely they had to control for that as well?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#24

Post by ve55 »

I've been supplementing glucosamine along with a large amount of other things for awhile now. I'm not too bullish on it in humans, but it doesn't seem like it hurts, and is definitely cheap: https://nearcyan.com/supplements

My latest favorites that I'm a bit more hopeful for are glycine, spermadine, and rapamycin.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#25

Post by madacol »

brownbat wrote: post #12
throw1234651234 wrote: post #4

Earlier quoted context omitted.

I am guessing they didn't control for lifestyle, etc. Someone who takes glucosamine either works out heavily and supplements (and probably watches their diet), or had joint surgery, and falls into the first group to some degree. Edit: Yea, reading the study, I don't see anything about controlling for fitness level. Running and caring about one's diet alone would account for this effect without glucosamine.

> Edit: Yea, reading the study, I don't see anything about controlling for fitness level. They specifically control for the following lifestyle factors: "smoking status, alcohol consumption, physical activity, body mass index (BMI) and vegetable and fruit consumption." (Ctrl+f for "covariates") In the conclusion, they acknowledge: "Although we had carefully adjusted for potential confounding lifestyle-related factors…

Awesome!, thanks for the tip `(Ctrl+f for "covariates")`

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#27

Post by throw1234651234 »

fluidcruft wrote: post #10
throw1234651234 wrote: post #4

Earlier quoted context omitted.

I am guessing they didn't control for lifestyle, etc. Someone who takes glucosamine either works out heavily and supplements (and probably watches their diet), or had joint surgery, and falls into the first group to some degree. Edit: Yea, reading the study, I don't see anything about controlling for fitness level. Running and caring about one's diet alone would account for this effect without glucosamine.

> Yea, reading the study, I don't see anything about controlling for fitness level. Doesn't table 2 and 3 show that they examined a bunch of relevant covariates including physical activity, smoking, alcohol use, diabetes, hypertension, cholesterol, statin and aspirin use? It's at least "something" at the very least and I'm not sure how you missed it if you were actually reading the study because it's very hard to mis…

"because it's very hard to miss". Haha rub it in, fair enough.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#28

Post by Malic »

mrfusion wrote: post #11
throw1234651234 wrote: post #6

Earlier quoted context omitted.

Yes - cartilage. If you eat chicken or something like that, eat the cartilage. You can do this on pre-cooked chickens you get from Sam's Club / Costco. If you eat chicken breasts only (which a lot of health-conscious people do), you don't get this benefit. I talked to Dr.Yang Jwing Ming (one of the few Kung Fu practioners with a Western phd and he said eating cartilage is one of the best ways to help reduce the risk…

Would chicken bone broth have it?

Quite probably. I am assuming that home-made methods are similar as industrial scale methods (put a bunch of chicken bones and connective tissue in a vat of water, simmer, strain).

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#29

Post by madacol »

ryanmarsh wrote: post #19

People who take glucosamine often do so BECAUSE of their active lifestyle, most don't have a use for it otherwise. This study did not control for lifestyle. In other news, people who own Peloton shoes likely to live longer...

> Covariates

> The UK Biobank used a baseline touch screen questionnaire to assess several potential confounders: ..., lifestyle behaviours (smoking status, alcohol consumption, physical activity, body mass index (BMI) and vegetable and fruit consumption),

You seem to not have read other comments, where the same complaint is made, and its answers.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#30

Post by NickM »

brownbat wrote: post #12
throw1234651234 wrote: post #4

Earlier quoted context omitted.

I am guessing they didn't control for lifestyle, etc. Someone who takes glucosamine either works out heavily and supplements (and probably watches their diet), or had joint surgery, and falls into the first group to some degree. Edit: Yea, reading the study, I don't see anything about controlling for fitness level. Running and caring about one's diet alone would account for this effect without glucosamine.

> Edit: Yea, reading the study, I don't see anything about controlling for fitness level. They specifically control for the following lifestyle factors: "smoking status, alcohol consumption, physical activity, body mass index (BMI) and vegetable and fruit consumption." (Ctrl+f for "covariates") In the conclusion, they acknowledge: "Although we had carefully adjusted for potential confounding lifestyle-related factors…

But if someone "works out heavily and supplements," that should show up in self reported physical activity, and indirectly in BMI.

Well, not to nitpick, but people with high muscle mass can easily end up with an "obese" BMI even if they have very low body fat. And it also doesn't take very many hours of working out per week to get jacked if you're doing heavy weightlifting and supplementing.

No idea if such people are common enough to skew the results of this study significantly, but it still makes me wonder a bit.

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