> 2FA compromised This is why sending or generating a OTP, that the user types in, is not secure. The user can be tricked into handing the OTP over the phone. Even the O365 system isn't secure (because the user can be told which number to tap over the phone). The only secure authentication these days is a non-communicable possession: Yubikey or similar. This reflects *very poorly on Twitter opsec.
What you need is a secure client, such as a dedicated tablet that is only used to access that service, along with a tamper-proof self-destruction system and a camera and set of sensors that can identify that only the intended person is present.
Even then the user can still be blackmailed to act in the attacker's interest, so you also need to offer the user a secure place to live in and make sure they are fully happy.