Covid-19 is causing a wide range of disorders in the nervous system
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Covid-19 is causing a wide range of disorders in the nervous system
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Re: Covid-19 is causing a wide range of disorders in the nervous system
#2I got a bad headache last time I had the flu. I even had to take paracetamol.
Re: Covid-19 is causing a wide range of disorders in the nervous system
#3AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG
Re: Covid-19 is causing a wide range of disorders in the nervous system
#4This virus is uncommonly indiscriminate in how many organ systems it damages. This may be due to its ability to deoxygenate a patient, systemic auto-immune response, systemic inflammation or vasculitis in organs, stroke like events with blood clots in multiple events, etc. What a beast of a virus!
Re: Covid-19 is causing a wide range of disorders in the nervous system
#5Re: Covid-19 is causing a wide range of disorders in the nervous system
#6Let me get this right... You significantly reduce the oxygen levels in a bunch of old people's brains for a month and they develop neurological issues? That is a remarkable finding. I would never have guessed.
Re: Covid-19 is causing a wide range of disorders in the nervous system
#7Something to consider and also something not discussed in the article: it's very possible that sars-cov-2 can directly infect neurons directly considering the expression of ace2 receptors across them.
https://www.biorxiv.org/content/10.1101/2020.04.07.030650v1
So beyond the risk of kidney failure stemming from damaged cardiovascular tissue debris jamming up nephrons (as well as potential direct kidney infection by the virus) and beyond the risk of stroke from the uptick of platelets and the redistribution of the marrow cells which produce them across the body (somehow. I can't find the research that identified this), there's also the risk that the virus is actually directly attacking neurons.
Not really a surprise considering how common ACE2 receptors are.
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I'm not a doctor. Not an epidemiologist either. Please fact-check me if I'm wrong.
Re: Covid-19 is causing a wide range of disorders in the nervous system
#8Note that similar effects have been observed with other critical illnesses: https://www.nejm.org/doi/full/10.1056/NEJMoa1301372
Re: Covid-19 is causing a wide range of disorders in the nervous system
#9This virus is uncommonly indiscriminate in how many organ systems it damages. This may be due to its ability to deoxygenate a patient, systemic auto-immune response, systemic inflammation or vasculitis in organs, stroke like events with blood clots in multiple events, etc. What a beast of a virus!
Other coronaviruses can infect the nervous system. In fact, there were papers out in 2018 describing neural infections by "human coronavirus".
Cytokine storms and their associated effects (like clotting ,etc.) are also present with other viral infections, like with the original Spanish Flu H1N1 strain (during the infamous "second wave").
"Regular" pneumonia can severely weaken you for months or a year, even if you have antibiotics.
This virus is absolutely not a magic virus. It is novel, but it is still a coronavirus.
Re: Covid-19 is causing a wide range of disorders in the nervous system
#10Something to consider and also something not discussed in the article: it's very possible that sars-cov-2 can directly infect neurons directly considering the expression of ace2 receptors across them. https://www.biorxiv.org/content/10.1101/2020.04.07.030650v1 So beyond the risk of kidney failure stemming from damaged cardiovascular tissue debris jamming up nephrons (as well as potential direct kidney infection by th…
That paper answers my first question, does neurological tissue have ACE2 receptors. The damage can also be a side-effect of oxygen deprivation. The existence of ACE2 receptors in the brain begs the question of how the SARV-CoV-2 virus crosses the blood-brain barrier. IIRC, dental surgery has been correlated to pathogens crossing the barrier. I wonder if that is a key factor here as well.