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Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

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61–70 of 105 posts

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#61

This is like the complement for other YC company, Lilia. Do you work together as founders in some way (I guess there are lots of overlap in the challenges you're dealing with)?

Yes! Well first and foremost, Alyssa is an amazing entrepreneur, someone I really enjoy speaking with, and is Canadian, so not much more to ask for there.

We catch up from time to time and I can imagine us partnering down the line. Notably, we do already partner with major female fertility companies in this space to offer packages for couples (like with Ava Fertility, a very rigorous and data-driven company that helps women track their ovulation periods)

I'll just add that we actually do testing & freezing as two linked but independent offerings. So Lilia matches the freezing component of what we do. A company like Modern Fertility (also YC) is closer to the testing component of what we do.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#62

Earlier quoted context omitted.

A very common-sense question to ask. We have agreements with our cryostorage providers to automatically transfer ownership of the assets to them in case Legacy ever did not exist in the future. So you would work directly with them and have the choice of either keeping the sample frozen there, or transferring it to a facility of your choice. We would help facilitate this to the greatest extent possible. We do not yet…

> So you would work directly with them and have the choice of either keeping the sample frozen there, or transferring it to a facility of your choice That reads pretty much as "good luck with that!" to me, I'm sorry. People would pay you exactly because they would never have a facility of their choice and in case it goes sour they would probably have to face a ridiculous price tag from some other new company not trul…

Hey - I hear you, but I don't think that's entirely fair. We are obviously building a company that we believe will go far, and will be around for decades, but we recognize there's no guarantee that will happen.

In a worst case scenario, folks could keep their sample frozen where it is and pay retail rates at those facilities instead of the wholesale rates we offer.

We are real people who care a lot about the people who are using their service, and their ability to have kids in the future. We would genuinely do everything we could to support.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#63
post #53

“ Reproduction in the age of COVID-19 lockdowns ”

Haha! You joke, but there are concerns that COVID-19 might affect male fertility (we are running a study to test this). So it's not the craziest idea to think about preserving your fertility during a global pandemic...

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#64
When we did IVF, I had two choices for providing my sample. Collect it at home and then drive it to the clinic, where I had a max of 15 minutes and had to keep the cup between my legs for the entire trip, or provide the sample at the clinic.

How do you keep the sample fresh for transport if it's collected at home?

ps. In case anyone was wondering I went with collecting at the clinic, and boy do I have some fun stories from that experience!

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#65
post #38

What is the viability over time of your samples? Even the highest quality cryostorage results in 10% loss per year.

Hey there, great questions. Sperm has been frozen for 40+ years and then thawed with no issues. In fact, scientists believe you can freeze sperm indefinitely with no loss in quality. That said, when you are going through the thawing process, you will lose about 50% of the frozen sperm. That's why we do a post-thaw count and motility check 24 hours after freezing, to make sure we know exactly how much of your frozen s…

Guaranteed viability at specific time points would give a significant advantage over other vendors.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#67
post #64

When we did IVF, I had two choices for providing my sample. Collect it at home and then drive it to the clinic, where I had a max of 15 minutes and had to keep the cup between my legs for the entire trip, or provide the sample at the clinic. How do you keep the sample fresh for transport if it's collected at home? ps. In case anyone was wondering I went with collecting at the clinic, and boy do I have some fun storie…

> boy do I have some fun stories from that experience

Not gonna lie, I'm kind of dying to hear them.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#68
post #64

When we did IVF, I had two choices for providing my sample. Collect it at home and then drive it to the clinic, where I had a max of 15 minutes and had to keep the cup between my legs for the entire trip, or provide the sample at the clinic. How do you keep the sample fresh for transport if it's collected at home? ps. In case anyone was wondering I went with collecting at the clinic, and boy do I have some fun storie…

Haha! You and me both! The worst part, to me, was it being referred to as "the specimen". I don't know why that always weirded me out.

Sperm can actually survive fine for 1-2 hours hours when kept near body temperature, so a 1-hour courier service is sufficient (and it usually takes less than 60 minutes). If there were any issues, we'd know when it arrived at the clinic.

For anyone outside of major cities, we do overnight shipping with Fedex's biohazardous materials division. We use a transport medium that keeps sperm alive for up to 48 hours during transit. You add it to the sperm, it protects it during that period, and it gets washed out (via centrifuge) when it arrives at our clinic. It's not perfect - you can expect to lose approx. 10-15% motility during that time, but is particularly useful for folks in rural areas or far from fertility clinics.

PS Always love hearing other folks' clinic stories... my favourite is hearing how clinics have their pornography stolen ALL the time and have to frequently re-stock.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#69

If one's sperm quality is poor, what does Legacy recommend be done about it? Is there anything specific or is it just general health/lifestyle improvements?

Yep - this is a great question and I have tons of thoughts here.

First and foremost: sperm quality is an indicator of overall health, and the two are closely correlated. This is both good and bad.

Good because living a healthier lifestyle improves sperm quality. Bad because there is no easy fix to improve sperm quality. Supplements are fine, and there is some limited research to support them, but they are not a panacea.

We brought on a sperm expert from Harvard - Dr. Mariel Arvizu - to create a protocol to assess and evaluate the lifestyle of our clients and create personalized recommendations based on what we believe is highest impact.

We bucket our recommendations into categories like nutrition, sleep habits, etc. and reference WHO or other trusted resources when possible.

We also get you in touch with a urologist (we have one on-staff) to do a consult if needed. He can discuss your specific case and provide insight.

Lastly, it depends on the results of your analysis. For example, morphology (how "normal" your sperm is) can be significantly impacted by things like using saunas, hot tubs, etc. or even from having the flu. There are simple and easy changes you can make to address things like that.

Sperm takes about 2.5-3 months to regenerate, so any changes you make today will be reflected in your sperm analysis after that time period.

Re: Launch HN: Legacy (YC S19) – we help men test and freeze their sperm

#70
post #64

When we did IVF, I had two choices for providing my sample. Collect it at home and then drive it to the clinic, where I had a max of 15 minutes and had to keep the cup between my legs for the entire trip, or provide the sample at the clinic. How do you keep the sample fresh for transport if it's collected at home? ps. In case anyone was wondering I went with collecting at the clinic, and boy do I have some fun storie…

> boy do I have some fun stories from that experience Not gonna lie, I'm kind of dying to hear them.

Alright. So I go to the clinic and check in with my wife. They take her off to get ready to "receive the sample". A few minutes later they call me up to the desk. The nurse looks at me, pulls something out of the desk, hands it to me with a cup, at tells me to go to room two.

To clarify, since it's relevant, I'm a white guy, my wife is Asian, and the nurse that checked me in is Black. What she handed me was a porn DVD of hardcore Asian porn. I guess she just assumed since my wife was Asian, that's what I was into. I saw in the drawer and there was a variety of choices, but I was never asked.

So I get into the room. To the left is a sink for hand washing with a small counter next to it. In front of me is a very standard office chair, but with a fresh absorbent pad on it (like what you put down when you're house training a puppy). In front of the chair is a 20 inch old-school CRT (this was in 2014, so it was old even then) with a built in DVD player. To the left of the chair is a huge rack with porn magazines.

I evaluate my situation, and decide I'm not going to use the chair, or touch it, or touch anything in the room that I don't have to, because I don't know why it just didn't seem right. Luckily I was smart and brought my laptop with me, so I pop that open and set it on the counter. Attach to the wifi and... all the porn sites are blocked. Apparently they use the same filter as all the other medical offices.

Luckily, being the enterprising engineering that I am, I bounce an SSH session through my home server.

So I start doing my business. I'm standing there with hand occupied, facing the door, when it opens! Apparently the nurse forgot to flip the sign to say "occupied" and also forgot to warn me to lock the door (protip: Always lock the door!). She turned back around and ran out, but I had to start over so to speak.

I finished up, sealed up the sample, washed up, rang the little bell, and the nurse collected my specimen. She was the consummate professional and didn't say anything about the walk-in.

I then went and sat in the waiting room while the doctor impregnated my wife.

ps. This story is a lot better when told in person after a few drinks.

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