I wonder how much the silicon quality differs on a single Threadripper Chip. It would really be interesting to see if it's feasible to Overclock the best numa node to a degree that gives this a couple of high single thread performance cores comparable to the 3900X or 3950X while retaining stability overall.
Do you mean the best ccx? Or best chiplet? There aren't any numa nodes here, and the cache & memory architecture are already the same as a 3900x.
Per-core & per-ccx overclocking does already exist on ryzen though, should work the same on threadripper.