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Diluting blood plasma rejuvenates tissue, reverses aging in mice

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Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#21

Post by abakker »

downerending wrote: post #18
exabrial wrote: post #5

Basically, stay hydrated? :)

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

If you’ve never encountered someone with low blood albumin, it is a very serious problem. You get terrible edema all over. Albumin helps you not retain the water in your cells, and instead to get the fluid back into your bloodstream for excretion.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#22

Post by mrfusion »

mcculley wrote: post #17

I just gave blood today. I have been trying to give blood as often as possible (once every eight weeks) to help keep cholesterol and iron low. Now, of course, I'm getting a free COVID-19 antibody test out of the deal. I'm wondering if this frequency of blood donations has a similar effect.

I was wondering that too. But donating only takes about 10% of your blood. So maybe not enough for any effect?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#24

Post by ASalazarMX »

mcculley wrote: post #17

I just gave blood today. I have been trying to give blood as often as possible (once every eight weeks) to help keep cholesterol and iron low. Now, of course, I'm getting a free COVID-19 antibody test out of the deal. I'm wondering if this frequency of blood donations has a similar effect.

> "They replace half the blood volume in mice"

I'd speculate the difference in volume is too great, having half your blood replaced with saline solution must feel awful.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#25

Post by wedn3sday »

This may go part of the way to explaining why women have a longer life span then men, they're constantly having to manufacture new blood. Men only have to create new blood if they donate or suffer some injury, but women's bodies are generating new blood all the time.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#28

Post by aomix »

ASalazarMX wrote: post #24
mcculley wrote: post #17

I just gave blood today. I have been trying to give blood as often as possible (once every eight weeks) to help keep cholesterol and iron low. Now, of course, I'm getting a free COVID-19 antibody test out of the deal. I'm wondering if this frequency of blood donations has a similar effect.

> "They replace half the blood volume in mice" I'd speculate the difference in volume is too great, having half your blood replaced with saline solution must feel awful.

Not really the same thing but I'm blood type O- and do the "Power Red" donation at Red Cross events. I have two units of blood taken out and the red cells and plasma are separated so the plasma can be returned along with saline to make up the difference in volume. I don't notice much of a difference besides feeling a little cold since the saline is at room temperature. However in that case I believe I'd only have ~10% of my blood volume replaced with saline.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#29

Post by naasking »

wedn3sday wrote: post #25

This may go part of the way to explaining why women have a longer life span then men, they're constantly having to manufacture new blood. Men only have to create new blood if they donate or suffer some injury, but women's bodies are generating new blood all the time.

Everyone generates new blood all the time. There's nothing gender specific about this. Our blood cells are completely replaced over a cycle of something like 4 months.

And this study is about plasma and albumin specifically.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#30

Post by naasking »

kgin wrote: post #20

The implication is not that young blood has specific positive properties, but that old blood has specific negative properties. Simply removing some of the "bad old blood" is already enough to measurably improve biomarkers. Identifying the bad stuff may go a long way to counteracting it in a more targeted way.

> Simply removing some of the "bad old blood" is already enough to measurably improve biomarkers.

God damn it, those blood letters were onto something!

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