Thanks for your response Nikolas!
Prisma's approach is well thought out, and I appreciate the new angle on an old and challenging problem. For Typescript users, especially new users, Prisma can be a big win. Abstracting SQL has huge benefits here (especially type safety/static analysis), and I look forward to seeing where this project goes.
That being said, my favorite database is PostgreSQL because it has so many features (and I'm just comfortable with it). At some point, a tool like Prisma (or Knex, TypeORM, etc) just cannot support all PostgreSQL features because it needs to support other flavors too. While some users may find this trade off acceptable, I always find myself hacking around the tool to use the raw features. Therefore, my ideal environment would be a full-featured PostgreSQL query builder.
TL;DR I see the benefits of Prisma, but they're not for me at this point