Yes, obviously it's not random nonsense with no reason behind it. Every conspiracy theory is rationalized by the people who believe it, with a framework of logic that makes sense to them, and Christians have been trying to decipher the Book of Revelations ever since it was canonized, breeding such conspiracy theories for a thousand years or more. I know some who adamantly believe the locusts in Revelations refer to Apache attack helicopters, for instance. Every war might be Armageddon, every plague might be a sign of the end times, every Pope and world leader might be the Antichrist. The paredolia, tea-leaf reading and phantom dot-connecting is as endless as it is futile.
The Mark of the Beast has been interpreted to refer to social security numbers, license plate numbers, credit card numbers, dollar bill serial numbers, bar codes, RFID codes, and any number of numbers throughout history. This is just the latest paranoid fixation of the Christian right attempting to justify their constant fear of the future. Tomorrow, when it turns out Bill Gates wasn't the antichrist all along, they'll find another number to obsess over.
It's still nonsense, even when the context is understood, and it doesn't deserve to be taken seriously, or treated with respect.