The OP says there are 6x10^21 Sudoku puzzles.
If we remove rotations and reflections, there may be (far) fewer unique Sudoku puzzles than we think. In fact, there are many sub-reflections that are essentially the 'same' puzzle:
Take the first three rows as a block, 'rotate' to the bottom of the puzzle - its still 'solved'. In fact permute the blocks of three rows in any order, still the 'same' puzzle in a sense.
Same with the first three columns.
Same with the three rows or columns in a block of three - permute them, the solution is 'unchanged'.
Relabel the digits from 1-9 as 9-1 - another 'reflection' which is the same puzzle pattern.
In fact, permute the digits all different ways - its still solved.
I'm not at all sure there isn't actually just one unique pattern to sudoku. But I don't know how to prove that one way or another.