Ask HN: What startup/technology is on your 'to watch' list? • Hacker News Board

Re: Ask HN: What startup/technology is on your 'to watch' list?

#181

Post by koeng » Sat, May 23, 2020, 2:59 AM UTC

thewarrior wrote: post #162

koeng wrote: post #113

Oxford nanopore sequencing. If a few problems can be figured out (mainly around machine learning and protein design), then it will beat every other biological detection, diagnosis, and sequencing method by a massive amount (no 10x, but more like 100x-1000x) It's hard to explain how big nanopore sequencing is if a few (hard) kinks can be figured out. Basically, it has the potential to completely democratize DNA sequen…

Can this be used to make faster corona virus tests ? If so maybe this is the time to Manhattan project this technology.

Generally, yes absolutely. I’ve been doing a project called “NanoSavSeq” (Nanopore Saliva Sequencing) in my free time. It’s published on dat right now since the raw files for Nanopore are really big (got too big for hashbase). There is one company doing it as well, but my version is completely open source and I’ve optimized it for affordable automation.

To give you a sense, you can buy one for 1k and do as much detection as a 64k device, and it’s small enough to fit in a backpack. One device should be able to do 500-1000 tests per 24hrs at a cost of about $10 per test, not including labor.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#182

Post by derekja » Sat, May 23, 2020, 2:59 AM UTC

sammnaser wrote: post #7

Tailscale.

nice, but what is the benefit over zerotier? Seem to provide very similar end results..

Re: Ask HN: What startup/technology is on your 'to watch' list?

#183

Post by azureus » Sat, May 23, 2020, 3:00 AM UTC

iamwil wrote: post #71

Rust lang - Memory safety through zero cost abstraction as a way to eliminate a large class of errors in systems languages is interesting. Especially if it allows more people to write systems programs. WASM - Mostly as a compile target for Rust, but I think this changes the way software might be deployed. No longer as a website, but as a binary distributed across CDNs. ZK-SNARKS - Zero knowledge proofs are still nasc…

Datomic .. not just because of datalog, but because its hands down the best implementation of a AWS lambda based workflow I've seen (Datomic Ions). It's such a peach to work with.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#184

Post by tmaly » Sat, May 23, 2020, 3:00 AM UTC

I think 3d printing still had enormous potential.

They are printing jet engine parts with it these days.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#185

Post by bionhoward » Sat, May 23, 2020, 3:01 AM UTC

Ubuntu, ParrotOS, Kali

Julia Lang is fun

For devops, Pulumi/CDK

I watch graph dbs but they all suck or are too expensive or have insane licenses (Neo4j, RedisGraph)

Differentiable programming, Zygote, Jax, PyTorch, TF/Keras

Optimal transport (sliced fused gromov-wasserstein)

AGI, levin, solomonoff, hutter, schmidhuber, friston

Ramda is amazing

George Church’s publications

im also super interested in molecular programming

DEAP is fun for tree GP a la Koza

Judea Pearl’s work will change the world once folks grok it

Secure multiparty computation

Re: Ask HN: What startup/technology is on your 'to watch' list?

#186

Post by zadler » Sat, May 23, 2020, 3:01 AM UTC

AI assisted code completion.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#187

Post by reitzensteinm » Sat, May 23, 2020, 3:01 AM UTC

sedgjh23 wrote: post #168

threeseed wrote: post #136

Earlier quoted context omitted.

I would never trust any self driving car that didn't use LiDAR. It's an essential sensor for helping to fix issues like this: https://www.youtube.com/watch?v=1cSw4fXYqWI&feature=emb_logo And it's not contrived since we've seen situations of Telsa Autopilot behaving weirdly when it sees people on the side of billboards, trucks etc.

Humans don’t need LiDAR to recognize billboards

Humans are underrated.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#188

Post by Gollapalli » Sat, May 23, 2020, 3:01 AM UTC

iamwil wrote: post #71

Rust lang - Memory safety through zero cost abstraction as a way to eliminate a large class of errors in systems languages is interesting. Especially if it allows more people to write systems programs. WASM - Mostly as a compile target for Rust, but I think this changes the way software might be deployed. No longer as a website, but as a binary distributed across CDNs. ZK-SNARKS - Zero knowledge proofs are still nasc…

wrt to Datomic there's also another Clojure DB using Datalog called Crux that's pretty interesting. I built my most recent project on that.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#189

Post by hanniabu » Sat, May 23, 2020, 3:01 AM UTC

chrdlu wrote: post #70

Circle.so ( https://circle.so/ ) With a rapidly growing creator economy, the tooling around building custom communities is very far behind. The cutting edge is a Facebook group, Slack channel, or a Discord server.

Would totally use it if they had discord login integration so it'd be easy to migrate our community over.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#190

Post by bionhoward » Sat, May 23, 2020, 3:02 AM UTC

koeng wrote: post #113

Oxford nanopore sequencing. If a few problems can be figured out (mainly around machine learning and protein design), then it will beat every other biological detection, diagnosis, and sequencing method by a massive amount (no 10x, but more like 100x-1000x) It's hard to explain how big nanopore sequencing is if a few (hard) kinks can be figured out. Basically, it has the potential to completely democratize DNA sequen…

Hell yes