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Factors associated with Covid-19 deaths in records of 17M adult NHS patients

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Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#41

Post by ip26 »

mindviews wrote: post #26

Here's a link to the paper: https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v... This is interesting data. I want to see Vitamin D status included in a large population study like this because I've been following two smaller studies covering about a thousand cases total that shows Vitamin D deficiency has a risk ratio of 10 to 20 (more even than being age 80+ in the above study). The studies: [1] https://p…

The critical question remains though- is vitamin D the causal factor, or instead an indicator of something else?

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#42

Post by [deleted] »

ip26 wrote: post #41
mindviews wrote: post #26

Here's a link to the paper: https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v... This is interesting data. I want to see Vitamin D status included in a large population study like this because I've been following two smaller studies covering about a thousand cases total that shows Vitamin D deficiency has a risk ratio of 10 to 20 (more even than being age 80+ in the above study). The studies: [1] https://p…

The critical question remains though- is vitamin D the causal factor, or instead an indicator of something else?

[deleted]

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#43

Post by xhedley »

TuringNYC wrote: post #33
lettergram wrote: post #19

I think one of the key takeaways is in the abstract: > People from Asian and black groups are at markedly increased risk of in-hospital death from COVID-19, and contrary to some prior speculation is only partially attributable to pre-existing clinical risk factors or deprivation

>> is only partially attributable to pre-existing clinical risk factors or deprivation I'd expect more it is attributable to less access to premium healthcare (remember, in the UK everyone gets healthcare, but not everyone gets privately-sponsored add-on healthcare)

UK privately-sponsored healthcare specialises in things that you cannot get free from the National Health Service or things where the wait time is long - for example knee surgery. People don’t use private healthcare for emergencies or intensive care. For example the prime minister was in intensive care in April - in an NHS hospital.

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#44

Post by peteretep »

JPKab wrote: post #25
lettergram wrote: post #19

I think one of the key takeaways is in the abstract: > People from Asian and black groups are at markedly increased risk of in-hospital death from COVID-19, and contrary to some prior speculation is only partially attributable to pre-existing clinical risk factors or deprivation

Deprivation equals poverty. Asian in Britain will primarily be Indian/Pakistani descent. I wonder if this is vitamin d related? Darker complexion of black and Asian could cause higher risks of vitamin d deficiency in UK.

Could be dietary related too, or factors relating to multiple generations of families cohabiting. That said, these are prevalent in the sunny parts of Asia too, which doesn’t appear to be suffering so much, so my suspicion would be Vit-D related.

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#45

Post by user4682 »

melvinroest wrote: post #40
mindviews wrote: post #26

Here's a link to the paper: https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v... This is interesting data. I want to see Vitamin D status included in a large population study like this because I've been following two smaller studies covering about a thousand cases total that shows Vitamin D deficiency has a risk ratio of 10 to 20 (more even than being age 80+ in the above study). The studies: [1] https://p…

"98.9% of Vitamin D deficient cases died while only 1.1% of them were active cases. 87.8% of Vitamin D insufficient cases died while only 12.2% of them were active cases. Only 4.1% of cases with normal Vitamin D levels died while 95.9% of them were active cases." Wait, only 13.3% (1.1 + 12.2) of all the active cases in total were vitamin D insufficient or worse? I thought the majority of people had insufficient vitam…

That's not right. 87.8 + 12.2% = 100% of insufficient etc. Active case = not dead

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#46

Post by martingoodson »

mindviews wrote: post #26

Here's a link to the paper: https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v... This is interesting data. I want to see Vitamin D status included in a large population study like this because I've been following two smaller studies covering about a thousand cases total that shows Vitamin D deficiency has a risk ratio of 10 to 20 (more even than being age 80+ in the above study). The studies: [1] https://p…

In case you weren't aware, controlled trials have shown that vitamin d supplementation protects against respiratory disease [1]. This is evidence that the association you highlight is more than a spurious correlation.

It's likely to be causal.

[1] https://www.bmj.com/content/356/bmj.i6583

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#47

Post by netsharc »

Obligatory, "Fucking Twitter thread" complaint. I dread reading

- Bullet point

- After bullet point

- In the form of a tweet per bullet point

- Trying to skip the bullshit

- And find the conclusion

(I'll stop now) ...and having the anxiety to be disappointed that I'll read so much bullshit and end up with nothing. Yes, in the end he links to the abstract which has the (unfortunately harder to parse) meat, but also yes, the Twitter thread disappoints, because he ends up tooting his own horn that they were the first, "this [study is] extremely important" and how he needs a sandwich... and seemingly that's where the thread ends? (TBH, thank god for that).

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#48

Post by peteretep »

new_realist wrote: post #12

It’s not surprising that historically plague-ridden Europeans would be less susceptible to a new blight then other ethnicities. Disease resistance has been selected for.

Asia got all the same plagues as Europe

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#49

Post by DoreenMichele »

new_realist wrote: post #12

It’s not surprising that historically plague-ridden Europeans would be less susceptible to a new blight then other ethnicities. Disease resistance has been selected for.

That's not how evolution works.

Cystic fibrosis is a predominantly Caucasian genetic disorder because one copy of the gene helps protect against certain historical plagues in Europe without being too debilitating. But two copies kill you gruesomely at a young age. And it kills you primarily by making you more prone to infection.

Kind of like how Sickle Cell works. It helps protect against malaria, but two copies of the gene are bad news.

Re: Factors associated with Covid-19 deaths in records of 17M adult NHS patients

#50

Post by _bxg1 »

tialaramex wrote: post #38
_bxg1 wrote: post #22

> Deprivation was also found to be a major risk factor What does this mean? Sleep deprivation?

Indices of Multiple Deprivation use a bunch of factors to measure how much it sucks to live somewhere. Other people are saying "poverty" but that's only part of the problem. https://en.wikipedia.org/wiki/Multiple_deprivation_index For example suppose you are very poor but you live where I grew up in Metroland. Lack of money sucks pretty badly, but in Metroland other deprivation factors are mostly low. There are jobs…

I always forget that "poor" over there doesn't also mean "unable to get healthcare" and "living in a tent under the highway".
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