391–400 of 426 posts
Here's an excellent video on the same topic that discusses David Sinclair's research https://youtu.be/XlFl0jDg0Jg
I like his interview here: https://youtu.be/IEz1P4i1P7s Granted I'm not completely sold on the supplements quite yet.
This article was jolly also https://www.bostonmagazine.com/health/2019/10/29/david-sincl...
Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…
At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…
Earlier quoted context omitted.
Sounds more like vampire-fiction like historical realities. People were "burned at the stake" for heretical ideas and challenging church dogma, not for looking suspiciously young. And the examples we have of living persons being deified was generally because they acquired enormous power (roman emperors, pharaohs and so on) not because of looking particularly young for their age.
> Sounds more like vampire-fiction like historical realities. People were "burned at the stake" for heretical ideas and challenging church dogma, not for looking suspiciously young. And the examples we have of living persons being defied was generally because they acquired enormous power (roman emperors, pharaohs and so on) not because of looking particularly young for their age. https://en.wikipedia.org/wiki/List_of…
Of course that was hard to prove or disprove, but we have examples of alleged witches accepting payment for harming/killing other people using whichcraft - like a contract killer. So at least the intention to cause harm was there in some cases.
There are numerous accounts of people having (alleged) supernatural abilities who was not persecuted, e.g ascetics surviving without eating for years and such. These were generally held in high regard, and could end up as saints.
Of course people could be accused for maleficium on really flimsy evidence so it could also hypothetically happen to the hypothetical slow-aging person just like it could happen to anybody else.
Earlier quoted context omitted.
Is being 40 and not being able to play tennis or go on long walks because you're too calorie-deprived that different from being 80?
That isn't the outcome though. Those on these strict diets are not lethargic.
Earlier quoted context omitted.
At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…
Someone I work with looks very youthful for their actual age, and that isn't always a good thing. When the team went on an offsite morale event jet skiing, he was told by the proprietor that he couldn't participate because their policy requires you to be at least 16 years old. He was 27 at the time. He never lived that down with his peers. When he tries to go to a bar with friends, he's sometimes accused of trying to…
I thought one of the main purposes of research publications was to allow others to reproduce/verify or refute your work. If you look at the methods section, here is what you get for a description of the magic plasma: 'We used a unique plasma fraction "Elixir" developed by Nugenics Research.' This seems to run counter to the philosophy of reproducibility. https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1....
To be fair, this would be a contender for the most epic discovery in human history. Would you simply give the solution away?
Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…
At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…
Earlier quoted context omitted.
I think Jared Diamond had a similar argument that seems valid. Roughly speaking, it boils down to the fact that you need 90 out of 100 subsystems in your body to be working. Your lungs, your heart, your skin, your brain, etc. They interact, but each part also needs to work on its own for you to live. Every one of those systems can fail and leave you dead. Since evolution only "cares" about you to the point where you…
>Since evolution only "cares" about you to the point where you bear children and raise them, what are the chances that it engineered ALL those systems to last FOREVER? This sentence turn things into such an anthropomorphic way, to the point that the concept of evolution en engineering don't make sense anymore. In the (scientific) evolution theories, evolution doesn't "engineer" life. It shapes life forms by environme…
There are scientific papers, BTW, which engineer solutions by evolutionary algorithms. Is that evolution or engineering? Clearly there's an engineering setup, made of all the constraints you speak about for the evolution process to take place, and that evolution process is also defined artificially, yet just like the real stuff, it follows a set of rules, so where's the divide? Why nature couldn't be engineering life with evolution, but humans could?
Your last point OTOH is quite relevant.
Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…
Evolution happens at all scales, not just the creature scale.
>18 rats were divided into three groups. 6 young rats (30 weeks old), 6 old rats (109 weeks old) & 6 old rats (also 109 weeks old) treated with plasma fractions from the young rats.
>Plasma fraction treatment consists of two series of IV injections, four times on alternate days for 8 days. A 2nd series of injections were given 95 days later. In its entirety, the experiment lasted 155 days.
>Blood was drawn at regular intervals for analyses to monitor the impact and cognitive functions were assessed 4 times. DNA methylation profiles of several organs were generated and age was calculated using six epigenetic clocks.
>Using the final versions of their epigenetic clocks the reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%.
Source some David Sinclair tweets (more in there) https://twitter.com/davidasinclair/status/125991292869585715...