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Age Reduction Breakthrough?

joshmitteldorf.scienceblog.com

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Re: Age Reduction Breakthrough?

#331

Post by tropheusduboisi »

WhompingWindows wrote: post #20
peter_l_downs wrote: post #4

As someone entirely outside this field, can someone with more inside knowledge give any insight into where this lies on the crank/hoax spectrum? A biorxv paper and a well-written blogpost don't really point either way.

1) It's only rat tissues and human tissues; any research published in only tissues only or in ratsonly , and not a large RCT in actual humans, needs to be taken with a huge grain of salt. 2) The research in the blog post is not fully summarized. You know it's a weak blog post when they post results WITHOUT SAMPLE SIZE. This is a GLARING omission and highly unscientific. The actual paper shows n=593 rat tissues and n=…

Some of the figures are based on N=6 treated old rats.

Re: Age Reduction Breakthrough?

#332

Post by Rury »

zemvpferreira wrote: post #298
rantwasp wrote: post #234

Earlier quoted context omitted.

there is a huge difference between enjoying food and being a slave to food. the best example I have in this bucket is sugar. If you depend on sugar you're basically a drug addict (i know, i know, but just because it's socially acceptable does not make it okay. there is research out there that show sugar is as bad as cocaine when it comes to how addictive it is and on the health effect). if you could pick just one int…

Well we were talking specifically about reducing calories by something like 50%, which automatically cuts out sugar, grains, probably meat. But what really kills it for me is not being able to move, dance, play sports. I understand how people can have fulfilling lives after losing the ability to do those things. Would I voluntarily give them up for a longer life? Probably not.

> which automatically cuts out sugar, grains, probably meat

Not necessarily. There's some evidence that when you eat might matter more than what you eat (given essential nutrition):

>Increasing daily fasting times, without a reduction of calories and regardless of the type of diet consumed, resulted in overall improvements in health and survival in male mice [1]

[1] https://www.nih.gov/news-events/nih-research-matters/fasting...

Re: Age Reduction Breakthrough?

#333

Post by tropheusduboisi »

peter_l_downs wrote: post #4

As someone entirely outside this field, can someone with more inside knowledge give any insight into where this lies on the crank/hoax spectrum? A biorxv paper and a well-written blogpost don't really point either way.

I'm a grad student in the aging bio field. Steve Horvath is well known and well regarded, but I'm pretty sure he just did the regressions. Other characters on the paper are more unusual including a former Investment Banker from India. I think the mainstream aging community view would be "wow these results too good to be true and I wish they presented more methodical details and individual data points". If it's true, it's quite exciting. In my own work, I've seen the rejuvenating effects of young blood.

Re: Age Reduction Breakthrough?

#334

Post by ajuc »

maxander wrote: post #63

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

Some people could have had that molecule, but it might have been undesirable for long-term survival of their tribe.

Re: Age Reduction Breakthrough?

#335

Post by lawrenceyan »

google234123 wrote: post #307
lawrenceyan wrote: post #166

It's impossible for an old cell to become young again, at least with our current level of technology, because that would require you to reverse all the mutations that have built up over time in that cell. If your argument is that our bodies have many different repair mechanisms, and that as long as we can figure out how to activate them properly, we can then reverse aging, I would caution you that while you're correc…

Aren't these mutations diluted any time a cell divides? Anyway, life span has been changed many time for many different species via evaluation. This is not an impossible problem.

> Aren't these mutations diluted any time a cell divides?

It's actually multiplied! When you clone from a corrupted source, the resultant cells contain all the mutations the original one had along with any new errors introduced during the process of copying.

Re: Age Reduction Breakthrough?

#336

Post by StanislavPetrov »

eganist wrote: post #70
maxander wrote: post #63

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

In the end, there can be only one!

Re: Age Reduction Breakthrough?

#337

Post by closeparen »

eganist wrote: post #70
maxander wrote: post #63

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

>25 by the time we reach 40

The socially desirable scenarios like this aren't really the interesting ones. How about looking 5 when you reach 25?

Re: Age Reduction Breakthrough?

#338

Post by koheripbal »

coryfklein wrote: post #265
amluto wrote: post #11

Earlier quoted context omitted.

When the author says things like: > But Katcher has no research grants or university lab or venture capital funding, no team of grad students mining databases and screening chemicals in the back room. > One thing Katcher has going for him is the correct theory. I start to suspect the author’s opinion is stronger than their evidence.

Given that many major scientific discoveries occurred with the prototypical mad scientist working alone, often apart from their main field, this description doesn't seem out of the norm for what I'd expect in somebody trying to urgently raise the signal of a very early and promising discovery. Let's consider the universe where Katcher has discovered the secret to aging. At some point in that universe, Katcher's work…

That may have been true a century or two ago, but that seldom occurs anymore now that scientific discovery has matured into an industry.

The vast vast majority of research discoveries happen within the system as part of large collaborations.

It's always healthy to have people going against the grain, but even they can find funding if they have ideas they can express coherently and that stand up to scrutiny.

Re: Age Reduction Breakthrough?

#339

Post by koheripbal »

zemvpferreira wrote: post #299
saiya-jin wrote: post #258

Earlier quoted context omitted.

Depends which parts gets prolonged - if you are at 80 deteriorated +-same as somebody who dies at 80, and they just keep fixing the next thing that is going to kill ya, then yes, that's a pure physical misery and spiral down progressive dementia (almost all old folks suffer from some form of it). Now if we would be 40-like in our 60s and so on, that's another story. But first thing that would probably change is retir…

Is being 40 and not being able to play tennis or go on long walks because you're too calorie-deprived that different from being 80?

That isn't the outcome though. Those on these strict diets are not lethargic.

Re: Age Reduction Breakthrough?

#340

Post by koheripbal »

themodelplumber wrote: post #252
koheripbal wrote: post #219

Earlier quoted context omitted.

I believe the most impactful thing you can do is drastically reduce caloric intake - like by 50%. Experiments have show large increases in lifespan, across mammals.

By 50% TDEE, or by 50% of what? And for how long? If that's the most impactful thing, these factors should very much be included

> And for how long?

Permanently.

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