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Age Reduction Breakthrough?

joshmitteldorf.scienceblog.com

81–90 of 426 posts

Re: Age Reduction Breakthrough?

#81

> Most of the explosion in aging research (and virtually all the venture capital startups) are looking to treat aging at the cellular level.... The truth, as Katcher understands it, is that, to a large extent, aging is coordinated system-wide via signal molecules in the blood. So the SV execs with their fit young blood-bois were right all along?

Also, telomeres shortening is a real thing. So... so much for a signal-only mechanics!

Re: Age Reduction Breakthrough?

#82

> Most of the explosion in aging research (and virtually all the venture capital startups) are looking to treat aging at the cellular level.... The truth, as Katcher understands it, is that, to a large extent, aging is coordinated system-wide via signal molecules in the blood. So the SV execs with their fit young blood-bois were right all along?

I had the exact same thought. I wonder where those execs get the information from and more importantly, how the information is filtered, because they are clearly a few years ahead of what's being posted on, say, HN.

Re: Age Reduction Breakthrough?

#83
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

https://en.wikipedia.org/wiki/The_Man_from_Earth

Re: Age Reduction Breakthrough?

#84
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

At the risk of the suggestion being a spoiler in and of itself, the movie The Man From Earth is basically about this topic.

Re: Age Reduction Breakthrough?

#85
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

It's also entirely possible that they just look younger, but aren't given much more of a lifespan because there's other issues with such a treatment. So someone that just ages well but ends up dying of otherwise natural looking causes and a typical age.

Re: Age Reduction Breakthrough?

#86

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

[deleted]

Re: Age Reduction Breakthrough?

#87
post #67

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

People who had this mutation could have died of causes other than aging.

My first thought too - maybe it's just wishful thinking, but the bible does talk about people who lived for thousands of years. We're prone to dismiss this as hyperbole from uneducated ancients, but maybe they actually did exist and this sort of thing was why.

Re: Age Reduction Breakthrough?

#88
post #7

Do we really want to live in a world where the billionaires live forever?

Economically, and historically, the more wealthy tend to try out the expensive, new technologies, then as market forces play out, such technologies become cheaper, to where most average workers can afford them (see genome sequencing costs decline over the past 15 years.) We need wealthy people to try out the expensive new advances. Just because someone is wealthy doesn’t necessarily mean they’re apart of the “evil bi…

Didn't the price of insulin in the US nearly triple in 10 years? The market is not always particularly efficient.

Re: Age Reduction Breakthrough?

#89
post #67

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

People who had this mutation could have died of causes other than aging.

On a long enough timeline, can't we assume that pretty much everyone is going to die of cancer?

Re: Age Reduction Breakthrough?

#90
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

Might I recommend the "The Man from Earth" (https://www.imdb.com/title/tt0756683/). Definitely worth checking out.
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