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Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

alz-journals.onlinelibrary.wiley.com

31–40 of 42 posts

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#31

Somewhat tangential, but I have a story about acid reflux that I think is worth sharing for anyone who is in a similar boat. Basically, I was having reflux symptoms minus the heartburn. Lots of throat issues, digestive issues, coughing, etc. My doctor looked everything over and concluded that reflux was the most likely cause and we did a treatment of PPIs for a few weeks. The PPI didn't help, but by the time the trea…

Thanks for sharing your experience.

Note that I am not a doctor, but I have my own theories that I want to share: post-nasal drip results in more swallowing, which triggers more acid production, which in turn results in more of the stomach content (ie. acid) getting back into the esophagus, hence GERD.

Acid that reaches high in the throat, for instance while lying down, will likely cause burning that will also result in post-nasal drip or similar symptoms. See the problem here? One issue amplifies the other. That's why once you get into a bad state it's difficult to return to some normality.

Also, other digestive system issues, such as IBS (irritable bowel syndrome), depending on the type and rootcause, will result in GERD. For instance, if you are often bloated, your digestive system may be slowed down significantly, which means there's no place for the stomach content to move into. Hence, more of the content may return into your esophagus.

The good news is that if there's no other underlying condition, these issues can be kept in check with lifestyle changes: diet and exercise (walking seems to be helping a lot; no surprise there, since humans have evolved to walk long distances; also no surprise that a sedentary lifestyle has so many negative effects on us).

Edit: there also seems to be a link between GERD and asthma, in the sense that acid reaching the airways, including lungs, may cause asthma.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#33
post #23

Earlier quoted context omitted.

What dietary changes? Idk if what I have is heartburn but the past 2 months or so I have been waking up to horrific stomach aches. Taking a round of Prilosec seems to have helped it. But I may want to backpedal on it given this news.

Typically people are asked to avoid acidic foods (tomatoes, citrus), raw onions, chocolate, caffeine, sodas, peppermint and high fat foods.

I don't get why high fat foods are lumped in here. I've started avoiding all the others you mentioned, and my reflux has stopped, but I'm on a ketogenic diet that's very high in fat.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#34

Earlier quoted context omitted.

I agree with the GP. Biology is chemistry, and the hydrogen electron shell is what's important in chemistry, not the nucleus. If the proton didn't act as a hydrogen nucleus, we wouldn't use the term PPI at all. Heavy water being (slightly) toxic doesn't have any bearing on the larger point.

>hydrogen electron shell is what's important in chemistry, not the nucleus The kinetic isotope effect would like to have a word with you.

Yes, there are extremely obscure corner cases in nature. The larger point, once again, stands.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#35

Somewhat tangential, but I have a story about acid reflux that I think is worth sharing for anyone who is in a similar boat. Basically, I was having reflux symptoms minus the heartburn. Lots of throat issues, digestive issues, coughing, etc. My doctor looked everything over and concluded that reflux was the most likely cause and we did a treatment of PPIs for a few weeks. The PPI didn't help, but by the time the trea…

Anedcote from me: I took Omeprazole for years and had to stop when I entered USMC bootcamp. All stomach issues disappeared when I started exercising and eating right. That was over 10 years ago and to this day my stomach is fine. I've kept up the habit of eating well and exercising mildly. TL;DR change your eating habits and exercise before trying to solve everything with a drug

Yeah obviously lifestyle should be a first course of action. In my case, no lifestyles changes helped. Which makes sense, since the underlying cause appears to have been allergies.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#36

Earlier quoted context omitted.

> the use of the term "proton" in chemistry which they use to denote the (positive) hydrogen ion H+/K+ ATPase is a proton pump, not a hydrogen ion pump. It evolved to pump protons, and mostly pumps protons. > the term "proton" belongs in physics exclusively and not chemistry which only deals with point-like nuclei carrying mass plus an electric charge, and the electron cloud Lots of biological machinery fails with he…

I agree with the GP. Biology is chemistry, and the hydrogen electron shell is what's important in chemistry, not the nucleus. If the proton didn't act as a hydrogen nucleus, we wouldn't use the term PPI at all. Heavy water being (slightly) toxic doesn't have any bearing on the larger point.

> the hydrogen electron shell is what's important in chemistry, not the nucleus

H+/K+ ATPase is literally a case of a proton pump that pumps protons. It’s in a class of proton pumps that pump far less efficiently, biologically-meaningfully less efficiently, with heavier isotopes. The nuclear structure is relevant.

“Hydrogen pumps” would be inaccurate. “Hydrogen ion pumps”, while practically fine, would be less precise.

General use of the term proton for hydrogen ions is debatable. But this is ironically a case where it isn’t.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#37
post #22

Somewhat tangential, but I have a story about acid reflux that I think is worth sharing for anyone who is in a similar boat. Basically, I was having reflux symptoms minus the heartburn. Lots of throat issues, digestive issues, coughing, etc. My doctor looked everything over and concluded that reflux was the most likely cause and we did a treatment of PPIs for a few weeks. The PPI didn't help, but by the time the trea…

which allergy medications worked best for you? I also have the same issues.

Right now Xyzal plus generic Nasacort. WARNING: "As with any medicine, you should ask your doctor or healthcare provider about using other allergy medications in conjunction with Nasacort."

Nasacort or similar is also nice to have around when switching allergy medications, since a lot of the 2nd gen stuff takes a week or more to reach full effect. So you can use it for those first two weeks on a new medication to help cover the gap.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#38

Somewhat tangential, but I have a story about acid reflux that I think is worth sharing for anyone who is in a similar boat. Basically, I was having reflux symptoms minus the heartburn. Lots of throat issues, digestive issues, coughing, etc. My doctor looked everything over and concluded that reflux was the most likely cause and we did a treatment of PPIs for a few weeks. The PPI didn't help, but by the time the trea…

Which spray worked for you?

Generic version of Nasacort.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#39
post #33
post #23

Earlier quoted context omitted.

Typically people are asked to avoid acidic foods (tomatoes, citrus), raw onions, chocolate, caffeine, sodas, peppermint and high fat foods.

I don't get why high fat foods are lumped in here. I've started avoiding all the others you mentioned, and my reflux has stopped, but I'm on a ketogenic diet that's very high in fat.

Some foods loosen the sphincter making it easier to get reflux. Like eating a slice of pepperoni pizza. My dietitian said each individual is different so you need to determine what works or doesn't works for you.

Re: Proton pump inhibitors (heartburn meds) linked with increased risk of dementia

#40
I had severe acidity issue and ended up in a condition called Barrett's esophagus . Doctor advised me to Omeprazole 40mg life long. After taking it for 6 months, i started following gluten free diet and all my gerd symptoms gone away. After 3 years, my Barrett's esophagus condition also reversed.
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