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Human body-on-chip platform could speed up drug testing

europeanscientist.com

21–30 of 47 posts

Re: Human body-on-chip platform could speed up drug testing

#21
We need to clone decephalized humans and livestock.

With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program.

It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and port it to the human model.

There would be a lot of political pressure, but this would be a space-age jump in supporting fundamental biological research, supplying renewable body parts and tissues, and keeping us healthy and young.

We need to do it.

If I ever get Elon Musk money and power, I'm doing this instead of rockets.

Re: Human body-on-chip platform could speed up drug testing

#22
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

Interesting; I have never heard the word "decephalized" before --- in what literature in this used?

Re: Human body-on-chip platform could speed up drug testing

#23
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

>With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program.

what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow.

>It the case of decephalized animals, you also get cruelty free meat.

only if you redefine cruelty to mean "what happens when bad things happen right in front of you". If a tree falls in a forest and no one hears...

>And that's how you bootstrap the program and port it to the human model.

of course, it's really no surprise. why are farmers less intelligent than hunter-gatherers? the process of domestication is self-imprinting. I think vegetarians really do have a point- not one that has to do with the cruelty of animals on an individual level, but with the very nature of domestication of animals itself. because the slippery slope of husbandry is ALWAYS eugenics. and the morality applied to animals always gets applied to humans given enough time.

>There would be a lot of political pressure, but this would be a space-age jump in supporting fundamental biological research, supplying renewable body parts and tissues, and keeping us healthy and young.

>We need to do it.

>If I ever get Elon Musk money and power, I'm doing this instead of rockets.

of course WE need to do it right? for millions of years humans lived and were forced to accept death, but THIS is the generation that we need to change by creating unholy abominations of our own kind.

You are pathetically evil. I will patiently wait for you to die.

Let me tell you who you are:

"Many modern people, on the other hand, are disturbed by the prospect of physical deterioration and death, as is shown by the amount of effort they expend trying to maintain their physical condition, appearance and health. We argue that this is due to unfulfillment resulting from the fact that they have never put their physical powers to any practical use, have never gone through the power process using their bodies in a serious way. It is not the primitive man, who has used his body daily for practical purposes, who fears the deterioration of age, but the modern man, who has never had a practical use for his body beyond walking from his car to his house. It is the man whose need for the power process has been satisfied during his life who is best prepared to accept the end of that life."

Re: Human body-on-chip platform could speed up drug testing

#24
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

Decephalized humans would be great for the sex industry.

Re: Human body-on-chip platform could speed up drug testing

#25
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

Decephalized humans would be great for the sex industry.

Decephalized HN posters would be great for fascist dystopia.

If you can justify the creation of human cattle the purposes of masturbation, you are a monster. You are worse than hitler, because even hitler cared about german people. You would be complicit with "I Have No Mouth And I Must Scream" just for your own sexual amusement. and because you "LOVE SCIENCE" so much

Re: Human body-on-chip platform could speed up drug testing

#26
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

>With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. >It the case of d…

> You are pathetically evil. I will patiently wait for you to die.

I have posed an engineering solution to disease that harms zero humans and furthers knowledge many fold, yet you wish for my death. Wow. You are incredibly misguided in your anger.

> what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow.

You can't dissect or experiment on thinking, feeling humans! That's immoral. Decephalized humans never have a thought process or consciousness. They're vegetables grown in a lab. Using them to further science and heal sick people is even more ethical than using lab animals, and I would argue it is our moral imperative to attempt this as soon as possible.

You do know that humans are animals and that our time in the universe is limited? My perspective is that there is no god other than us to lift ourselves up to reach the stars. We have to help each other as best as we can, and this technological reverse salient is begging for exploitation. It unlocks so much potential.

Biology is a platform, a machine, an ecosystem. We need to fully commandeer it. We're still in the punch card phase, and I want to see us reach the biological equivalent of compilers.

It's a fluke that I even exist, and I want to take full advantage of my limited time here. You're putting up artificial barriers and limitations.

Re: Human body-on-chip platform could speed up drug testing

#27
post #21

We need to clone decephalized humans and livestock. With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. It the case of decephalized animals, you also get cruelty free meat. And that's how you bootstrap the program and p…

>With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. >It the case of d…

Your world view is very bizarre to me. Death of sentient beings is fine or good, but creation of inanimate, non-sentient things - which will invariably reduce sentient suffering and death - is evil?

>what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow.

...Huh? What?

>only if you redefine cruelty to mean "what happens when bad things happen right in front of you". If a tree falls in a forest and no one hears...

How? Going from killing conscious beings to not killing them anymore is the opposite of cruelty.

Re: Human body-on-chip platform could speed up drug testing

#28
post #26

Earlier quoted context omitted.

>With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. >It the case of d…

> You are pathetically evil. I will patiently wait for you to die. I have posed an engineering solution to disease that harms zero humans and furthers knowledge many fold, yet you wish for my death. Wow. You are incredibly misguided in your anger. > what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. You can't dissect or…

[flagged]

Re: Human body-on-chip platform could speed up drug testing

#29

Earlier quoted context omitted.

>With thousands of brainless bodies kept alive on life support, you have test subjects for a limitless number of experiments that would have never been possible before. You also create a never-ending O negative blood supply and organ harvesting program. what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. >It the case of d…

Your world view is very bizarre to me. Death of sentient beings is fine or good, but creation of inanimate, non-sentient things - which will invariably reduce sentient suffering and death - is evil? >what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. ...Huh? What? >only if you redefine cruelty to mean "what happens when…

>Your world view is very bizarre to me

the idea that people should simply live and die naturally is becoming increasingly antiquated

>what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow.

The primary driving force behind growth and change in society (by proxy of individuals attempting to fulfill the power process) is competition. The conflict that causes this motivation is death- that is to say that the root reason why people do things is because they will eventually not be able to do things. In a society where no one has to compete in the "sexual marketplace", and no one dies within a reasonable lifespan, there largely is no reason to change or grow

>How? Going from killing conscious beings to not killing them anymore is the opposite of cruelty.

Is the alternative to this kidnapping people and harvesting their organs? No of course I don't support that. If you are suggesting that letting people die because they needed organs harvested in a gravely unethical manner is "killing". then yes, I do support that form of "killing" because it is so far removed from the actual meaning of killing that it no longer bears meaning.

Re: Human body-on-chip platform could speed up drug testing

#30

Earlier quoted context omitted.

Your world view is very bizarre to me. Death of sentient beings is fine or good, but creation of inanimate, non-sentient things - which will invariably reduce sentient suffering and death - is evil? >what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. ...Huh? What? >only if you redefine cruelty to mean "what happens when…

>Your world view is very bizarre to me the idea that people should simply live and die naturally is becoming increasingly antiquated >what society would ever produce decephalized humans when they could produce cephalized humans? a weak society that could not possibly adapt or grow. The primary driving force behind growth and change in society (by proxy of individuals attempting to fulfill the power process) is compet…

>the idea that people should simply live and die naturally is becoming increasingly antiquated

Indeed, and I personally think that's a very, very good thing. Preventing aging and death is one of the most noble things we as a species can strive towards, in my opinion. I believe this should be the ultimate goal for all sentient beings, not just humans. I believe more and more people are coming to share this sentiment, and I believe that if humanity still exists in 100 years from now, this will be the prevailing world view.

>The primary driving force behind growth and change in society (by proxy of individuals attempting to fulfill the power process) is competition. The conflict that causes this motivation is death- that is to say that the root reason why people do things is because they will eventually not be able to do things. In a society where no one has to compete in the "sexual marketplace", and no one dies within a reasonable lifespan, there largely is no reason to change or grow

This is an extremely common argument, and in my opinion, a weak one. Competitive forces can and do achieve great results across many domains, but to suggest that the only way to achieve great results is through competition, conflict, and death across all areas is a very simplistic and narrow view of reality, I think. I think it's a fallacy of the converse.

Longevity researchers like Aubrey de Grey have good counter-arguments to these sorts of arguments against anti-aging and immortality. For a basic overview, I think the counter-arguments he gave on his recent appearance on Joe Rogan are good: https://www.youtube.com/watch?v=9-z0kglwpwo

I believe eliminating aging and death in humans will enable far more growth, change, and happiness than we ever could have experienced before. (To be clear, true immortality will never be possible; quasi-immortality may eventually be possible; biological immortality seems pretty likely to be possible within this century or next century.)

I don't think if you told people they weren't going to eventually die of cancer and aging that they would no longer want to do anything. If anything, it would more effectively enable them to pursue their true passions, since they wouldn't need to save up for retirement before a certain age. (They could if they wanted to, but they would no longer have to.)

In an immortal society, there would still be market competition, and sexual competition, and all sorts of other competition. (I think even if you did remove those two sorts of competition, society would still grow and change effectively, but that's a separate topic.) Although it's an unavoidably influential force at this time, we aren't slaves to natural selection, and to the extent possible, I think we should try to become the opposite of slaves to it. I think we should try to be self-determining.

People should be able to die whenever they want to. They shouldn't have to slowly fall apart and crumble into goo, largely beyond their control. You only have one chance to exist, and it's extremely brief. Why make it briefer than it otherwise could be?

>If you are suggesting that letting people die because they needed organs harvested in a gravely unethical manner is "killing". then yes, I do support that form of "killing" because it is so far removed from the actual meaning of killing that it no longer bears meaning.

But what about decephalization is at all unethical? I don't understand. It seems like the opposite. I think it's one of the most ethical things we can possibly do. There would be far less need to do potentially harmful, torturous, or lethal experiments on thinking animals, including humans. And for humans who want to consume meat, they can do it in a way that doesn't require inflicting pain and death on conscious entities.

I do happen to think it probably isn't practical for testing. The brain is such a crucial component of the body's functioning, so even making one would be very difficult; and even if you could, it would probably significantly influence drug effects and whatever else you're trying to test.

But it seems very ethical, to me. You described it as "human cattle" - no, it's human rocks. In my opinion, we do want to do our death- and suffering-inducing activities on cow rocks and human rocks, not actual cows and actual humans. Rocks are completely incapable of thinking or feeling. It's not unethical to smash two rocks together. The lifeform would never have a brain or anything like it to begin with - it's not removing a brain from an existing person, or something insane like that.

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