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Vitamin D Insufficiency is Prevalent in Severe Covid-19

medrxiv.org

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Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#21

Post by ashtonkem »

mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

Vitamin D isn’t even really a vitamin, if it were we wouldn’t be able to synthesize it. It’s actually a hormone.

Now if you’ll excuse me, I think I’m going to take my next call out on the porch.

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#23

Post by James_Henry »

simonsarris wrote: post #2

I find this compelling: > Strikingly, 100% of ICU patients less than 75 years old had VDI [Vitamin D Insufficiency] Since mid-March I've been trying to keep track of Vitamin D/Sunlight suggestions and papers here: https://simonsarris.com/sunlight

I feel like this is a very expected finding. It would be more compelling to see the covid-19 severity among patients with and without VDI but matched by egfr or one of the many many other confounders. A lot of things are correlated with severity of metabolic disease that could be the thing that makes covid-19 severe in this population.

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#24

Post by dfawcus »

mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

FWIW: I stopped this[1] recently on Wikipedia.

I'm sure someone could chase up more authoritative references.

[1] https://en.wikipedia.org/wiki/Immune_system#Vitamin_D

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#25

Post by ashtonkem »

the_jeremy wrote: post #15
mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

A psychiatrist I saw multiple years ago told me to start taking Vitamin D. I went more or less blindly with 5,000 IU after reading some internet articles. I got my blood checked last year and decided I should probably actually know if I'm doing too much or too little. I was within 5% of the middle of the healthy range for vitamin D levels. For reference, 5,000 IU is >800% the FDA daily recommended value. People with…

Also, the absorption of it orally appears to be kind of finicky.

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#26

Post by subsubzero »

mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

I also had a vitamin D deficiency that was found after a particularly bad string of colds, my Dr told me to take a supplement(5000ius daily) of vitamin D and have not seen anything like it since. Apparently windows cars/office block sunlight's ability to create vitamin D in a person so a car ride or sitting near an office window does not provide any help. And if you are in a office job you are def. not getting enough vitamin D.

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#28

Post by danenania »

mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

Does anyone know of a rule of thumb for how much time spent in direct sunlight is equivalent to a Vitamin D supplement? Is an hour per day (on average) sufficient?

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#29

Post by simonsarris »

the_jeremy wrote: post #15
mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

A psychiatrist I saw multiple years ago told me to start taking Vitamin D. I went more or less blindly with 5,000 IU after reading some internet articles. I got my blood checked last year and decided I should probably actually know if I'm doing too much or too little. I was within 5% of the middle of the healthy range for vitamin D levels. For reference, 5,000 IU is >800% the FDA daily recommended value. People with…

> For reference, 5,000 IU is >800% the FDA daily recommended value.

Unfortunately the daily recommended value was established erroneously and should be much higher. Many research papers mention this. For example:

> The Institute of Medicine recommendation for adults younger than 70 years of age is 600 IU of vitamin D daily. We are told that this would achieve a level of 50 nmol/L in greater than 97.5% of individuals.6 Regrettably, a statistical error has resulted in erroneous recommendations by the Institute of Medicine leading to this conclusion and it might actually take 8800 IU of vitamin D to achieve this level in 97.5% of the population.7 This is a serious public health blunder.

From the 2015 paper, Vitamin D for influenza

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

Re: Vitamin D Insufficiency is Prevalent in Severe Covid-19

#30

Post by o10449366 »

mindcrime wrote: post #8

Interesting thing... Vitamin D is one of those things that, when vitamins come up on HN, you will often hear the refrain that "it's the one vitamin that large numbers of people are actually deficient in and ought to supplement." I've heard that many times over the years and I have taken a Vitamin D supplement on and off (more off than on) over the years. When this COVID-19 thing first hit, I had a physical scheduled…

Likely placebo. Vitamin D is extremely soluble in our bodies and takes months of consistent supplement dosage to have an effect on our baseline levels.
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