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A Third Solution

paulbuchheit.blogspot.com

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Re: A Third Solution

#281

Post by mrfusion »

tim333 wrote: post #265
mrfusion wrote: post #256

Earlier quoted context omitted.

I wonder why we always jump to the China approach of forcing people to do things. Why not use an incentive system instead? You’d need a lot of work to design a good system but for example pay $100 for a positive test and proof that you isolated that day. (For proof of isolation maybe a system texts you at random times and asks for a picture of something in your house. Eg. 10:13am you get a text asking for a picture o…

You don't really need to pay. At the infectious disease place in Marseille they offered free tests, hundreds lined up to get tested and the the number of infections in community dropped dramatically.

Great point. I guess my thinking was to make sure folks could afford to isolate and increase compliance even more.

Re: A Third Solution

#282

Post by predxionbio »

lvs wrote: post #232
predxionbio wrote: post #173

Earlier quoted context omitted.

0) From a clinical perspective this is data we are generating on an on going basis. Analytically this is a largely a function of the characteristics of the affinity, specificity of the capture molecule used to capture the target (viral particle). As you point out EUA gives opportunities to launch sooner... But it's still critical to validate technogies both internally and externally probably to a greater extent than…

How is chip fabrication is more scalable than plastic 384-well plates and cotton swabs? Nothing shy of a home pregnancy test is more scalable than qPCR.

Great question.

This is one of the implementations we're actually developing. One of the challenges with the implementation of testing on this scale is not necessarily on the technology/assay but on implementation. How do you reasonably test millions of folks each and every day, or said another way actually get millions of nasal swabs, saliva, etc on 384 well plate?

I think our ultimate approach is much more akin, albeit with a bit more sensor voodoo magic, to a at home pregnancy test than 384-well plate qPCR tests at central labs.

Re: A Third Solution

#283

Post by nickysielicki »

> It appears that the virus travels through the air, so whenever possible, it’s important to avoid crowds of people or indoor spaces with shared air. The virus is about the same size as the particles in cigarette smoke (though it would usually be part of a larger droplet), so I find it helpful to imagine a smoker exhaling smoke, and what it would take to avoid inhaling too much of that second-hand smoke.

I just got back from a bike ride and I went through an area where a lot of homeless hang out. I could strongly smell urine and smoke while I was waiting at a stop light under a bridge. Do I need to be concerned that I just exposed myself?

Re: A Third Solution

#284

Post by downerending »

clairity wrote: post #82
downerending wrote: post #59

This is a pleasant thought, but we can't even get most people to obey speed limits most days, even though it's far easier and we know it would save large numbers of lives.

strictly speaking, speed in and of itself isn’t the primary problem, it’s distracted driving in its many forms. speed only makes the severity of those accidents greater.

[footage not found]

Speed kills.

Re: A Third Solution

#285

Post by Mikeb85 »

renewiltord wrote: post #188
Mikeb85 wrote: post #132

Earlier quoted context omitted.

> people who are antibody-positive have a standardized note confirming recovery How do you prove recovery if you were never proven sick first? As an example, I had all the symptoms of Covid in late February, the same severity many people in my age group described, yet was never tested since our health authority dropped the ball and claimed community transmission wasn't a thing back then. If I tested positive for anti…

Test positive. Wait 14 days. Now you're positive clean.

And is someone going to verify I waited 14 days? Also, why should I have to if I already am clean?

Re: A Third Solution

#286

Post by TenJack »

zmmmmm wrote: post #212

The post refers to an alternative method of testing for COVID-19 based on surface plasmon resonance that would have significant advantages, but unfortunately it provides absolutely no real substantiation that the test exists or works. The link about surface plasmon resonance goes to a generic Wikipedia page, the link about saliva is a small scale study that was conducted on RT-PCR not surface plasmon resonance, and t…

I gathered the same thing. Basically the gist is, if we can develop a cheap, fast, and effective test for COVID-19 then we can test everywhere and re-open everything.

Re: A Third Solution

#287

Post by paxys »

nickysielicki wrote: post #283

> It appears that the virus travels through the air, so whenever possible, it’s important to avoid crowds of people or indoor spaces with shared air. The virus is about the same size as the particles in cigarette smoke (though it would usually be part of a larger droplet), so I find it helpful to imagine a smoker exhaling smoke, and what it would take to avoid inhaling too much of that second-hand smoke. I just got b…

The virus can travel through droplets and other large particles, so you definitely have to watch out for people sneezing etc. around you. There isn't any consensus, however, for whether it is airborne or not, i.e. whether it can be in regular exhaled air. Of course you should take precautions regardless.

Re: A Third Solution

#288

Post by krrrh »

danieltillett wrote: post #170

I hope everyone has noticed that if this approach could wipe out COVID-19 it could wipe out influenza and even the common cold.

Imagine how naive our immune systems would become. It could have unpredictable effects, like increasing the rate of novel zoonotic disease transmissions.

Maybe something like this is what set the stage for the common cold wiping out the aliens in War of the Worlds.

Re: A Third Solution

#289

Post by predxionbio »

tptacek wrote: post #229
zmmmmm wrote: post #212

The post refers to an alternative method of testing for COVID-19 based on surface plasmon resonance that would have significant advantages, but unfortunately it provides absolutely no real substantiation that the test exists or works. The link about surface plasmon resonance goes to a generic Wikipedia page, the link about saliva is a small scale study that was conducted on RT-PCR not surface plasmon resonance, and t…

According to my biochem-undergrad kid, surface plasmon resonance is a thing; it had come up in classes. "It's like doing an ELISA with no secondary antibody". Someone here will know what that means. I don't!

A regular ELISA/immunoassay is: surface->Ab->proteinSounds like your undergrad kid has been paying attention in class...

Re: A Third Solution

#290

Post by mikepurvis »

TenJack wrote: post #286
zmmmmm wrote: post #212

The post refers to an alternative method of testing for COVID-19 based on surface plasmon resonance that would have significant advantages, but unfortunately it provides absolutely no real substantiation that the test exists or works. The link about surface plasmon resonance goes to a generic Wikipedia page, the link about saliva is a small scale study that was conducted on RT-PCR not surface plasmon resonance, and t…

I gathered the same thing. Basically the gist is, if we can develop a cheap, fast, and effective test for COVID-19 then we can test everywhere and re-open everything.

Hasn't that always been everyone's argument? That's the crux of Pueyo's "dance" [1], that as long as you've contained the initial outbreak, you can pretty much go back to normal if you track movement and have the capacity to test everyone who comes in contact with an infected person.

[1]: https://medium.com/@tomaspueyo/coronavirus-learning-how-to-d...

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