It has to be noted: it's quite a strange approach all round - this framework reads all the data into memory. So if you have a 100GB genome it will read 100GB into memory. Presumably it stays in memory uncompressed so we are talking hundreds of GB to process even a single whole genome sample. This may indeed have some performance benefits, but it's a very impractical approach from a hardware point of view. Few places…
The authors go in more detail around this topic in: https://journals.plos.org/plosone/article?id=10.1371/journal...