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Psilocybin Produced in Yeast

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181–190 of 214 posts

Re: Psilocybin Produced in Yeast

#181
post #57

Earlier quoted context omitted.

People with psychiatric disorders need spiritual journeys. Spiritual journeys heal and cleanse the mind, heal and cleanse the soul. Do not try to strip that away. The commodification of medicine troubles me--I prefer the perspective of sacred medicine. It goes roughly definitionally / tautologically: if something heals you, is it not sacred? And likewise, if something is sacred, it heals you. By definition. The idea…

> People with psychiatric disorders need spiritual journeys. Spiritual journeys heal and cleanse the mind, heal and cleanse the soul. Do not try to strip that away. No opinion on the article or yours but where are you getting this opinion? Why or how, do psychiatric disorders need spiritual journeys. Not all people believe in spiritual journeys or are capable of it. There is noting scientific about what you're sugges…

Note what I did and didn't say. I did NOT say: "People with psychiatric disorders will be cured by spiritual experiences."

Having a mental disorder is a pretty miserable existence, in several different ways. Anything that could reasonably be described as a spiritual experience will bring you a sense of wonder, fun, release, enlightenment, excitement, new perspective, added insight about your life, and a sense of connection to others or the Earth or the cosmos. I have difficulty believing that those things will not help people with psychiatric disorders. Everyone needs those things and I cannot take seriously any assertions to the contrary.

I also have difficulty accepting your statement that "not all people believe in spiritual journeys or are capable of it." Some people don't believe in fun? Some people don't believe in healing, in excitement? I have met some of those people but I do not think we should consider that level of disconnection with life as anything but a terrible tragedy. And that we should try to find ways to connect with those people, bring a little fun and joy into those people's lives if we feel able and willing to do so.

It's kind of like, not all people believe in eating food, and those people are in serious danger and need our help.

Re: Psilocybin Produced in Yeast

#182
post #68
post #57

Earlier quoted context omitted.

> People with psychiatric disorders need spiritual journeys. Spiritual journeys heal and cleanse the mind, heal and cleanse the soul. Do not try to strip that away. No opinion on the article or yours but where are you getting this opinion? Why or how, do psychiatric disorders need spiritual journeys. Not all people believe in spiritual journeys or are capable of it. There is noting scientific about what you're sugges…

Many (most?) people taking this substance report having some sort of mystical/spiritual experience. I doubt they are actually convening with the divine, but whether/how/why the substance causes that affect in people is certainly a part of "science". I also don't think the spiritual journey aspect should be dismissed so lightly. Its being investigated to help depression. Perhaps inducing a "spiritual" state in people…

>I doubt they are actually convening with the divine.

I appreciated your comment overall but this statement stood out to me. May I ask what guided this choice of words? Why would you have an opinion on it one way or the other?

Re: Psilocybin Produced in Yeast

#183

Earlier quoted context omitted.

Why can't science be spiritual?

Because HN is primarily the realm of scientism : science as a religion. Anything that deviates from that will be -4'ed within an hour. And it even appears that discussing such will also incur the wrath of non-comment -1 voters. Without requiring a justified reason of a downvote, I don't expect this to be fixed in any reasonable timeframe. It's an emperor's new clothes problem.

I like the idea of requiring a response in order to downvote.

Re: Psilocybin Produced in Yeast

#184
post #81

Earlier quoted context omitted.

Distillation on home premises without proper safety procedures is a recipe for explosions and for contaminated/weird distillation products. I'm a home-brewer, and have cold-distilled a couple of things (you can get up to about 22% that way IIRC), but I'm good with it being a little difficult to get started distilling, from a safety standpoint.

"I'm good with it being a little difficult to get started distilling, from a safety standpoint." If you screw up home canning, you can get botulism, which can very easily kill you and anyone else who consumes it. Same if you simply store some home-made garlic olive oil in your refrigerator. Cook beans wrong and you could get very sick or even die. Cooking on a gas stove could result in your house catching on fire, or…

Only kidney beans though

Re: Psilocybin Produced in Yeast

#185

Earlier quoted context omitted.

I wonder if this type of thinking is a side effect of dmt et al. Perhaps they aren't as safe as is believed.

> I wonder if this type of thinking is a side effect of dmt et al. Based on extensive reading in the community, I would say overwhelmingly yes. To what degree this derives directly from the substance, versus an "unlocking" of thinking modalities that already exist but are dormant (or not normally consciously perrceivable) is interesting and worth study, but disciplined, logical thinking is not something you'll find m…

My educational background is in mathematics and physics. I think you'll find I can give disciplined, logical thinking a run for your money. Logic after all is only an adherence to predetermined axioms in a consistent fashion, not an algorithm for which axioms you should and shouldn't adopt to begin with.

Just like science cannot claim to hold an opinion on a phenomenon it has not studied, logic should have no opinion on the great sea of life that happens outside formal systems. Should I spend my time by the river or walking among the trees? There's no strictly logical general answer. You can say, "It's thunderstorming, you shouldn't be outside at all," but that presupposes that I care about surviving. If I do not share that axiom ie I want to live as the wild, and brave the storm with my body in danger, that's not strictly speaking illogical. It's just not your logic. The logic does not share the same axioms but may be perfectly consistent unto itself.

Re: Psilocybin Produced in Yeast

#186

Earlier quoted context omitted.

I know this statement is false, because I've read thousands of discussions. I challenge you to attempt to prove your assertion with evidence. If you make an attempt, you will quickly realize that you are objectively incorrect . And then, in light of that realization, perhaps there may be value in reviewing and contemplating, at length , your earlier statement: > Think about why these kinds of arguments are made on di…

https://psychedelicreview.com/why-do-magic-mushrooms-cause-n... It would seem that at least some people think Nausea is a problem.

Claim: "You'll find nausea and vomiting in just about every discussion about consuming psilocybin mushrooms.

Challenge: "I know this statement is false, because I've read thousands of discussions. I challenge you to attempt to prove your assertion with evidence. If you make an attempt, you will quickly realize that you are objectively incorrect."

Response (from the claimant, thus far):

Reply (third party): "It would seem that at least some people think Nausea is a problem."

Key distinguishing phrases: "just about every", "some"

Result: Downvote the person who speaks precisely, and objectively correctly.

To those who disagree, first consider how one might physically implement a test of the initial assertion: "You will find or in ~every ".

Might this work: [CountOf forum posts for ] - [CountOf forum posts containing keywords for ]

Does it seem likely that CountOfKeywordHits / CountOfTotalPosts is going to be up in the range of ~"just about every"? I'm guessing no.

Consequence: Here is where my point lies. If people on HN can't be bothered to not only speak/read accurately and precisely, but punish (downvote, vilify, throttle, stonewall) those who do so (or advocate for such ideas), what might be the general quality of ideas that get persisted in people's minds as a consequence of reading the information that exists in such an environment?

And if this is happening on HN, imagine what the state of affairs is on other platforms (Reddit, Facebook, the media, etc). Now, compare this idea ("facts" that people consume are often literally incorrect) to the current level of ~"general understanding" the broader public seems to exhibit when it comes to the "accurate understanding of relevant facts related to what is going on", across a wide range of important topics (something that seems to come up in discussion, now and then). Might some correlations appear?

And if we looked a bit harder, might a plausibly causative relationship be observable, to some degree? Does the idea that people's internal mental model is affected by the quality of information they consume seem implausible, or controversial? Or, does this perhaps vary based on which (out)group of people we're talking about?

But wait...how true is "facts that people consume are often literally incorrect"? This seems like a rather extraordinary claim. And you know what they say about extraordinary claims!

Again, consider how one might physically implement a test of this extraordinary assertion? Not so simple as doing a keyword search this time. I know of no AI that could do it. Maybe it would require a manual analysis. So, here's an interesting idea: let's say one was to go through this entire thread, and tag each post with a boolean or score indicating the epistemic soundness of claims made within it.

Heck, while we're at it, what others dimensions might yield some interesting output? And if we're going to do one thread, why not do 5 or 10, picking topics from a variety of subject areas, including ones that are bound to be controversial, but are simultaneously extremely important public matters (environment, pandemics, politics, tax policy, etc), where the concerns of people who advocate for old-fashioned ideas like high quality discourse, precision in speech and interpretation, and intellectual honesty, can't be so easily dismissed/framed as stupid, a waste of time, invoking flame wars, "gish-galloping", etc.

So, considering this scenario, what would an analysis of actual written words, consistently interpreted in accordance with the HN guidelines, reveal to us of what is going on in our community? If we did the same thing in other communities, what might we find there? How confident is everyone here that our sense-making is so much superior to that of the that are commonly mocked for their "lack of intelligence", and tendency to "believe whatever they uncritically read online"? I for one would like to find this out. I wonder if anyone else would. I wonder if anyone cares.

But enough gish-galloping for one day. I imagine I'm just concerned about nothing, things are really not all that bad out in the real world. Most likely, everything is not only mostly under control, but getting better on a daily basis. And besides, it's not like any of this is our responsibility. No, every problem that does exist in the world is someone else's fault. The world isn't what we make of it, it is what the others make of it. As it has always been, and as it will always be.

Re: Psilocybin Produced in Yeast

#187
post #68

Earlier quoted context omitted.

Many (most?) people taking this substance report having some sort of mystical/spiritual experience. I doubt they are actually convening with the divine, but whether/how/why the substance causes that affect in people is certainly a part of "science". I also don't think the spiritual journey aspect should be dismissed so lightly. Its being investigated to help depression. Perhaps inducing a "spiritual" state in people…

>I doubt they are actually convening with the divine. I appreciated your comment overall but this statement stood out to me. May I ask what guided this choice of words? Why would you have an opinion on it one way or the other?

Its based on my personal beliefs. I don't have much to back it up one way or another (maybe occam's razor at most). Metaphysical claims usually come down to i believe what i believe because i believe it, and i am no exception.

The main reason i included it was because psybin's comment which i was responding to was very dismissive of "spirituality", and i think there is still valid things to talk about related to spiritual "journeys" regardless of if you think there is some metaphysical force you are connecting to, or if you believe its simply a drug-induced altered state.

Re: Psilocybin Produced in Yeast

#188
post #169

Yeast is everywhere. I was recently reading about how to cultivate wild yeast in a jar left on your countertop for use in making sourdough bread. What happens when some of the yeast you capture in the environment is producing psilocybin? I saw no mention in the article of considerations to keep these genetic modifications contained within the psilocybin manufacturing process.

Generally, most genetic modifications like these are harmful to the competitiveness of the microorganism in the wild. It's possible that producing psilocybin could help it be more competitive, but this would be the exception rather than the rule. Generally, the organism expends so much energy and material producing the engineered substance that it's worse at doing other things.

Imagine if it actually started beating out other yeasts until we starting having difficulty baking bread that doesn't make people hallucinate.

I'm not saying this is likely to happen, but just imagine...

Re: Psilocybin Produced in Yeast

#189
post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

I think you could make the same argument about.... everything? Farming and selective breeding vs. hunting and gathering? Inventing modern materials rather than using wood and stone and animal parts? Pretty much everything. "Mistakes from the past?" Which specific ones are you speaking of? I don't doubt there have been many, but if you are talking about choosing not to simply take things as nature gives them to us, well, I guess you want to return to the stone age or something, but the world doesn't support 7 billion people doing things that way.

Re: Psilocybin Produced in Yeast

#190
post #145
post #68

Earlier quoted context omitted.

Many (most?) people taking this substance report having some sort of mystical/spiritual experience. I doubt they are actually convening with the divine, but whether/how/why the substance causes that affect in people is certainly a part of "science". I also don't think the spiritual journey aspect should be dismissed so lightly. Its being investigated to help depression. Perhaps inducing a "spiritual" state in people…

Please can you provide sources?

A source that people believe that psilocybin helps them achieve a mystical state? Or a source about something else?

Isn't the defining feature of a mystical experience that the participant feels that they had one (its a concept about subjective internal states, not an objective thing to measure beyond i guess self-reported surveys). Given that its going to be self reported anyways, i think the general acedotes about psilocybin inducing spirtual "states" is pretty compelling.

Anyways, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772431/ is a study on the effect of psilocybin induced mystical experiences.

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