431–440 of 585 posts
Could we already start with this? There are almost no deaths in young people, so how about we send the youth to a Corona Summer Camp for a week or 3? https://www.worldometers.info/coronavirus/coronavirus-age-se...
relying on numbers from February feels sub-optimal, especially when they're entirely using numbers from one country, not many countries.
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I just sent your article to my contacts at the White House, Department of Defense, DARPA and a couple of other acronym agencies. I sent this to Director level people (or just under) at those agencies. No guarantees (they are all swamped). I hope they respond and put you in touch with the right people.
Thanks. This is the problem I have run into which is all the right people are so busy at the moment that they don’t have time to look at something like this from someone like me.
The results of a study in austria with 1500 randomly selected citizens have just been published, just 5 have been found to be currently infected with SARS-CoV2. The conclusion is that the prevalence of asymptomatic cases is about 0,32%, CL95 is 0,12-0,76%. Link (in german): https://www.sora.at/nc/news-presse/news/news-einzelansicht/n...
This goes contrary to what other studies have found. In the Stockholm metropolitan area they found that 2.5% percent of the population was infected [1]. In in a community in Germany, which was the epicenter of the outbreak for a time, they found that 15% of the population tested positive for antibodies [2]. In Iceland they found that 88-93% of the infections are undetected [3]. [1] https://www.folkhalsomyndigheten.se…
On top of that, other research indicates some folks might be recovering without developing antibodies at all (they could be clearing the infection with only their innate immune systems). In that case we couldn't be totally sure about the upper bound anytime soon:
https://www.medrxiv.org/content/10.1101/2020.03.30.20047365v...
I think this is a great idea to get community involvement upon. I'm sure you know there's a network of researchers on Twitter (I'm aware of the one centered around the Krogan lab in UCSF i.e. @KroganLab), and on Reddit (reddit.com/r/covid19) that have been posting ideas back and forth. Consider posting there.
I like your idea because it circumvents a number of ethical issues, but may be time/resource consuming. Another approach but one that quickly hits those ethical issues during testing would be to knockout immunosuppressant genes as popularly described by: https://www.nytimes.com/interactive/2020/04/03/science/coron... (preprint https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3....). Perhaps mice model? An in between approach that might be better, would be to target your search by looking for changes that likely inactivates the immunosuppressant genes.
I and I'm sure many others dearly hope your approach works. Godspeed sir.
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>ADE is more a problem for the vaccine approaches. It is one reason we may never have a vaccine for this disease. This is at least partly why there are no SARS/MERS vaccines. There's a paper I'll try to dig up where 4-8 (can't remember) modified vaccine candidates were tested in multiple animal species, and in each case except one, immunity was conferred but exposure to the virus lead to a dangerous autoimmune respon…
That's not ADE as I understand it. ADE is where the virus gets grabbed more easily by cells thanks to the antibodies on it proving handles.
That's why I'm waiting for confirmation of immunity. So far I've only seen increasing numbers of reports of reinfection but that may just be faulty testing.
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I mean, yes, Berman/Braga era Trek has a fairly consistent style both visually and thematically because that's how they wanted it, but to privilege that style as "real" (or "proper", as you have it) requires considerable justification as yet not provided. Even from that era, First Contact not only used a largely horror/action-movie style then unprecedented in Trek, but went far out of its way to cast doubt on the Fed…
> but to privilege that style as "real" (or "proper", as you have it) requires considerable justification as yet not provided It's arguably the largest consistent body of work in the entire Star Trek franchise, the one that was the peak of its popularity, the one that fleshed out the universe and is most recognizable. Also somewhat unique compared to other science fiction, which I can't say about post-ENT installatio…
One wonders whether the same might be true of Picard. Unfortunately, we don't get a chance in B&B-era Trek to see how he reacts to the test of the Dominion war, but his behavior in First Contact is nonetheless telling. If even "the conscience of the Federation" so signally fails to live up to the ideal - if it's only the desperate intervention of someone from a time universally regarded in Picard's own as a cesspool of cruelty and horror that saves him from his own mad, vengeful hatred - does that tell us something about the merit of the ideal? If even the person who most exceeds all others in following its guidance can so signally fail, are we wrong to question its value as a guide for those less uniquely exceptional?
I can't disagree that Discovery and Picard are very different from what's gone before. But, then, the TNG-era works were very different from TOS, too. Where we differ, I think, is that I don't see anything wrong with that - indeed, I don't see how it could be any other way. The works are made in the context of, and in dialogue with, their times - as you yourself note with regard to TNG and DS9. These are very different times from those in which the earlier shows were made, and it would be much more of a surprise to see new Trek shows try to ignore that difference than to see them embrace it.
"Infinite diversity in infinite combinations." It's a worthy ideal, and an apropos one to see expressed in the same series of TV shows and movies whose own originator codified it.
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The sequencing is not the important thing here, but the search for strains with gene deletions and contact tracing everyone in the area to find more cases to prove the strain is attenuated. As far as I know nobody is doing this.
You’re fairly hard to get in contact with directly. Would you mind sending me an email? I don’t think I’ll be a your “middle hop”, but I’ll try. My email is lyndsy@ .com My username here is my real name, and I should be easy to find. It’s also my username on Twitter, Keybase, and most other popular platforms.
> If you think you might be that first hop person then please get in contact with me at daniel.tillett@gmail.com
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I invited danieltillett to repost https://news.ycombinator.com/item?id=22798626 . My reason is to build up a body of community reactions to the idea, that can serve as a basis for deciding whether to promote it further. I don't know Bill Gates, but I do know some people inside YC who are hard at work on this problem, and maybe they know someone who knows someone, etc. If it's just a repetition of the previous thread,…
I didn't realize this; I actually flagged this article.
I'm glad people are realizing that all this social distancing is merely a pause button on the virus. Once we press play on society, exponential growth will happen again and we will have effectively rolled back the clock until we reach herd immunity through things like the OP's suggestion. At least this next time we'll hopefully have more PPE.
I'd much rather live in a world where everyone is required to wear masks all the time than live in a world where we are all told to stay home all the time. I believe it's also well established that any measures taken to slow the spread of a new virus will always result in fewer total deaths, in that sense quarantining is much more effective than just being a pause button.
A properly fitting mask is uncomfortable. It hurts your nose, it hurts your ears. If you wear spectacles they fog up. People don't tolerate them, and so they fiddle with the mask, taking it off and putting it back, or dropping it under their chin.
Here's what happens when you wear a mask for a couple of shifts at work.
https://twitter.com/gabbyjackson95x/status/12479391789623255...
https://twitter.com/george_kerris/status/1241821041107906560
https://twitter.com/LeaBasra/status/1246467174589517825
https://twitter.com/CorneliaLG/status/1247309904106393608
https://twitter.com/paigeleigh95/status/1247509440405876738
https://twitter.com/gsmarri/status/1241845315587715073
https://twitter.com/molliemariaa/status/1246285482130059267
https://twitter.com/freyja_woolston/status/12472261992120115...
https://twitter.com/johnnynash69/status/1248278245914693639
https://twitter.com/TJGrundy/status/1247771125553065986
https://twitter.com/rosenorth_/status/1247235204957208577
https://twitter.com/erikalouxx/status/1245240263947227136
https://twitter.com/ilkahannah/status/1248395954102759431
https://twitter.com/LeanneThornex/status/1247587759025504256
1) Wouldn't natural selection result in a milder strain crowding out a more deadly strain? After shelter in place lifts, people with a mild strain will be more likely to go out and spread the virus whereas people with the deadly strain will be more likely to stay home sick.
2) Is there any consensus on whether we become immune to COVID after getting it (e.g. if we get a mild strain will we really be immune to a deadly one)? I've heard different opinions and I'm wondering what the leading hypothesis is at the moment.
Thanks!