Live data from Hacker News

Anton (Computer)

en.wikipedia.org

11–20 of 48 posts

Re: Anton (Computer)

#11

Earlier quoted context omitted.

I would say it's likely that the SV Anton was named after this.

I’ve always assumed it was a reference to Anton LaVey (seemed appropriate for Gilfoyle to name his server after the founder of the church of satan). It would be interesting to know which theory is correct.

Good point, and while SV does have a lot of obscure references, this one may be a bit too obscure. Happy coincidence perhaps.

Re: Anton (Computer)

#12
post #9

“The performance of a 512-node Anton machine is over 17,000 nanoseconds of simulated time per day for a protein-water system consisting of 23,558 atoms.[5] In comparison, MD codes running on general-purpose parallel computers with hundreds or thousands of processor cores achieve simulation rates of up to a few hundred nanoseconds per day on the same chemical system.” 17,000 ns of simulation per day sounds crazy small…

There's quite a nice plot from a review paper of D.E. Shaw Research that lists the timescale of several biological processes (and compares it to other experimental methods), https://www.annualreviews.org/doi/full/10.1146/annurev-bioph... (Figure 2). Anton has been extremely helpful for studying the basic science of protein dynamics in academia and has been applied in industry (namely at Relay Therapeutics), but drug discovery is a long process so we still haven't seen the fruits of those long simulations yet.

Re: Anton (Computer)

#13
post #9

“The performance of a 512-node Anton machine is over 17,000 nanoseconds of simulated time per day for a protein-water system consisting of 23,558 atoms.[5] In comparison, MD codes running on general-purpose parallel computers with hundreds or thousands of processor cores achieve simulation rates of up to a few hundred nanoseconds per day on the same chemical system.” 17,000 ns of simulation per day sounds crazy small…

I don't think it's been very helpful, since computational modeling in general doesn't seem to be a cure all for drug discovery challenges

Re: Anton (Computer)

#17
post #7

I have a lot of respect for david shaw. He quit managing his hedge fund day to day because he said something along the lines of finance make me stupid or something and went back to doing something useful. If only more of our elites realized this (and cared to do something useful with themselves)

Me as well. It does seem that the whole point of being a billionaire is to do whatever you want. I can't imagine why so many seem to stick to managing their creations, which after a while can't be much fun.

Most billionaires got their wealth through inheritance. All they know is to manage the wealth creation agent that was handed down to them.

Most of the self made ones too have spent a large chunk of their lives perfecting the wealth generation agent which made them rich. It would be like asking a pro NBA player to also take a shot at being a pro NFL player. It’s not what they trained for; they would need to learn a new skill, a new industry and they will most likely fail anyways.

Only a minority of such billionaires actually end up doing different things; Elon Musk comes to mind. Most are victims of their previous successes.

Re: Anton (Computer)

#20
post #7

I have a lot of respect for david shaw. He quit managing his hedge fund day to day because he said something along the lines of finance make me stupid or something and went back to doing something useful. If only more of our elites realized this (and cared to do something useful with themselves)

https://nymag.com/intelligencer/2019/09/david-e-shaw-college...
Post reply on HN