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Hydroxychloroquine Update for April 6

blogs.sciencemag.org

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Re: Hydroxychloroquine Update for April 6

#71

Post by brandon272 »

threeseed wrote: post #59
moron4hire wrote: post #41

Why are we talking about drugs in the public media? This is like people demanding certain drugs from their doctors because they saw it in pharmaceutical commercial.

Because it's actively being pushed by right-wing media and the President. We have a Presidential election in November. And there is a proven, strong correlation between the strength of the economy and your chance of being elected. You can't have a strong economy and people feeling happy when they are stuck at home without a job and fearful of leaving the house. So they need to get people back to work. And the only wa…

That might work if the election was say, within the next 15 to 30 days. Trying to scam the general population into believing that an unproven drug is some kind of "magic" cure is an awfully bold and risky move 7 months from an election, especially before a potentially staggering number of deaths has been realized.

Re: Hydroxychloroquine Update for April 6

#72

Post by threeseed »

brandon272 wrote: post #71
threeseed wrote: post #59

Earlier quoted context omitted.

Because it's actively being pushed by right-wing media and the President. We have a Presidential election in November. And there is a proven, strong correlation between the strength of the economy and your chance of being elected. You can't have a strong economy and people feeling happy when they are stuck at home without a job and fearful of leaving the house. So they need to get people back to work. And the only wa…

That might work if the election was say, within the next 15 to 30 days. Trying to scam the general population into believing that an unproven drug is some kind of "magic" cure is an awfully bold and risky move 7 months from an election, especially before a potentially staggering number of deaths has been realized.

Consumer confidence, unemployment rate and economy strength are all lagging indicators.

People need to be working, shopping, socialising and the media reports of death and despair completely over before everyone is going to feel happy about the world. If we ended COVID-19 today it would take months for the negative effects to wear off. Just look at what happened after 9-11.

There is a reason that the same right-wing commentators and Trump were so aggressively pushing the "get back to work" easter timeframe and are still talking mostly about jumpstarting the economy. Politics doesn't stop just because of COVID-19.

Re: Hydroxychloroquine Update for April 6

#73

Post by HarryHirsch »

tptacek wrote: post #69
HarryHirsch wrote: post #68

Earlier quoted context omitted.

People with rheumatoid arthritis are not a good population to study. We know that certain comorbidities increase death rate. Now you have people with immune system problems taking an immunosuppressive drug. The outcome tells you nothing.

Jeremy Faust does not agree with you. https://twitter.com/jeremyfaust/status/1246801663345618944 But it's still being given, so I'm certain there are other doctors still holding out hope.

He says "If it does work, it‘s not as good as you hope it is" and "STUDY THE DRUGS!" What he doesn't say is "lovely natural experiment" and "GREAT Stuff".

Re: Hydroxychloroquine Update for April 6

#74

Post by pazimzadeh »

hexl wrote: post #60
pazimzadeh wrote: post #30

Taking Chloroquine too soon might promote viral infection by inhibiting the anti-viral response. https://sciencedirect.com/science/article/abs/pii/S016635421... CQ is for patients who have uncontrolled inflammation in response to the virus, not to be taken as a prophylactic.

If I remember correctly, someone on twiv's podcast said that the inmune inhibition occurs months into treatment for lupus patients taking HCG. So, Could you explain in layman terms why this is not the case? Most of us have no clue about what's being discussed in the paper.

I haven't seen any evidence that (Xydroxy)chloroquine alone directly inhibits anything to do with the viral replication. The closest thing that I found is that Thymoquinone inhibits Mouse coronavirus replication and is generally protective of lungs:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933739/ https://erj.ersjournals.com/content/50/suppl_61/PA4935

Chloroquine is an antipyretic and relieves symptoms like fever from diseases like Malaria and dengue.

Chloroquine stops the inflammation from going out of control, which a good thing during an infection. But if you take it when you don't have an infection, it could stop you from detecting viruses in the first place.

The paper I cited in the previous comment mentions that Chloroquine is a TLR7 inhibitor. TLR7 is a receptor that senses of single-stranded viral RNA. https://www.sciencedirect.com/science/article/abs/pii/S01663...

Re: Hydroxychloroquine Update for April 6

#75

Post by sunnyP »

dmh2000 wrote: post #32

isn't it the azithromycin that causes the arrhythmia and i heard it is recommended to use doxycycline instead for anyone vulnerable to that side effect.

I just read an article where Dr. Mohammud Alam in Long Island is treating covid19 patients that have heart issues with that combination. https://townhall.com/tipsheet/katiepavlich/2020/04/06/here-a...

Re: Hydroxychloroquine Update for April 6

#76

Post by m0zg »

m0zg wrote: post #3

Counterpoint: http://www.leparisien.fr/societe/sante/chloroquine-ne-perdon... You can do double blind studies until your patients are literally blue in the face, or you can try what works now. That is literally the choice at the moment. According to Peter Navarro, a good percentage of NYC patients are getting HCQ at the onset of symptoms now. Cuomo wants more of it, because it "appears to be working". Oklahoma is giv…

Yale School of Medicine is onboard with HCQ as well. I guess they're total schmucks over there, nowhere close to the genius of Derek Lowe, who's not even a doctor. /s

Why can't you people admit that Trump was right?

https://files-profile.medicine.yale.edu/documents/7801c631-3...

Re: Hydroxychloroquine Update for April 6

#77

Post by microtherion »

buboard wrote: post #51
benjohnson wrote: post #24

Earlier quoted context omitted.

Quinine used to come from the bark of a tree - that bark is available as a nutritional supplement. It's also is used to make the bitter taste of Tonic Water.

Someone did the calculations. Ppl need to drink 200 gin tonics per day

Yes, but is there a downside as well?

Re: Hydroxychloroquine Update for April 6

#78

Post by ceejayoz »

legostormtroopr wrote: post #19
ceejayoz wrote: post #7

Earlier quoted context omitted.

“You can do double blind studies until your patients are literally blue in the face, or you can try what works now.” https://en.wikipedia.org/wiki/Politician%27s_syllogism

Linking to wikipedia articles about logical fallacies isn't a debate tactic.

That's debatable.

https://en.wikipedia.org/wiki/Rimshot

Re: Hydroxychloroquine Update for April 6

#79

Post by hprotagonist »

benjohnson wrote: post #24
war1025 wrote: post #17

My completely anecdotal experience with the Hydroxychloroquine story is that researchers keep pooh-poohing it and people in the field keep having success with it. All I know is that based on the aggregate of information I've seen thus far, if I come down with Coronavirus, I want to be prescribed that stuff.

Quinine used to come from the bark of a tree - that bark is available as a nutritional supplement. It's also is used to make the bitter taste of Tonic Water.

it mostly still does. You _can_ synthesize it but the yield's godawful.

Re: Hydroxychloroquine Update for April 6

#80

Post by treeman79 »

robocat wrote: post #55

“hydroxychloroquine itself actually lowers the activity of the innate immune system; that’s why people take it for lupus and for rheumatoid arthritis. Many people are saying that perhaps it will work best if taken early in the course of infection” (from article.) Yet HCQ takes a very long time to act as an efficient immunosuppressant (1 to 3 months for Lupus) as per https://news.ycombinator.com/item?id=22798370 which…

I have Sjogrens. A cousin to Lupus.

One month after starting this drug I noticed a decrease in symptoms.

I stopped taking it for a couple weeks. Symptoms started again.

So works but is slow. The stimulant aspect however hits in an hour and last all day, and into the next morning. And oddly seems have some viagra like effects. I have to really be careful if I take other stimulants.

Antibiotics also keep symptoms at bay, but doctors won’t write script despite success.

This drug does a lot to the body. Good and bad.

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