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Hydroxychloroquine Update for April 6

blogs.sciencemag.org

41–50 of 99 posts

Re: Hydroxychloroquine Update for April 6

#42
post #15
post #9

Earlier quoted context omitted.

> doesn't mean it's universally safe _Table salt_ is not safe. Eat 100 grams of it and you will die. This does, however, mean that it's not as "dangerous" as the mainstream press wants you to believe. It's a 50 year old drug used all over the world. If it was "deadly", we'd know it by now. CDC itself recommends taking it _as a prophylaxis_ when heading to the areas where malaria might be present: https://www.cdc.gov/…

I think we can all intuitively see the distinction in risk tolerance between table salt consumption and HCQ consumption.

> I think we can all intuitively see the distinction in risk tolerance between table salt consumption and HCQ consumption.

Good thing we have doctors that can decide the best course of treatment via HCQ then.

Re: Hydroxychloroquine Update for April 6

#43
post #32

isn't it the azithromycin that causes the arrhythmia and i heard it is recommended to use doxycycline instead for anyone vulnerable to that side effect.

Erythromicin and azithromycin can have a negative effect but supposedly the chloroquine ALSO can have an effect, so subbing in doxycycline will help but might not be enough.

Re: Hydroxychloroquine Update for April 6

#44
post #36

Earlier quoted context omitted.

This drug is not administered to everyone though. It's only been tested and verified for people with I believe lupus and malaria. So we don't know the implications of rolling it out to millions of people worldwide. That's why you do clinical trials.

> So we don't know the implications of rolling it out to millions of people worldwide. It’s 70+ years old. It’s a well-understood drug. It’s an experimental treatment, not an experimental medicine. It’s also frequently prescribed to grandmas with rheumatoid arthritis.

> It’s a well-understood drug

For treating the issues it was designed for. Not for treating COVID-19.

Re: Hydroxychloroquine Update for April 6

#45
post #3

Counterpoint: http://www.leparisien.fr/societe/sante/chloroquine-ne-perdon... You can do double blind studies until your patients are literally blue in the face, or you can try what works now. That is literally the choice at the moment. According to Peter Navarro, a good percentage of NYC patients are getting HCQ at the onset of symptoms now. Cuomo wants more of it, because it "appears to be working". Oklahoma is giv…

Opting to listen to Navarro over Fauci is a very odd choice.

Look, I get that certain discussions on this damn site resist dragging politics into it all, but this is pretty important: Navarro has nowhere near the qualifications that Fauci does and there is no reason to listen to him on this.

You're contributing to a larger problem with misinformation at a time when it's not needed. Listen to the medical professional, not the economist.

Re: Hydroxychloroquine Update for April 6

#46

Why are we talking about drugs in the public media? This is like people demanding certain drugs from their doctors because they saw it in pharmaceutical commercial.

In part there's a desire to tell people that we have "a cure" or "a vaccine" ready to go because it suppresses panic and anxiety by creating the impression that the problem is solved. Naturally, telling people that before it's actually true causes new problems, so now we have people fighting to combat misinformation.

Re: Hydroxychloroquine Update for April 6

#47
post #42
post #15

Earlier quoted context omitted.

I think we can all intuitively see the distinction in risk tolerance between table salt consumption and HCQ consumption.

> I think we can all intuitively see the distinction in risk tolerance between table salt consumption and HCQ consumption. Good thing we have doctors that can decide the best course of treatment via HCQ then.

I completely agree.

Re: Hydroxychloroquine Update for April 6

#48

Taking Chloroquine too soon might promote viral infection by inhibiting the anti-viral response. https://sciencedirect.com/science/article/abs/pii/S016635421... CQ is for patients who have uncontrolled inflammation in response to the virus, not to be taken as a prophylactic.

There is a clinical trial going on to check for just that. The hope is that when taken as a prophylactic it prevents entry into cells and give the immune system an advantage over the pathogen, but as you say, the immunosuppressive effects are a concern. We'll see soon enough.

Re: Hydroxychloroquine Update for April 6

#49
post #3

Counterpoint: http://www.leparisien.fr/societe/sante/chloroquine-ne-perdon... You can do double blind studies until your patients are literally blue in the face, or you can try what works now. That is literally the choice at the moment. According to Peter Navarro, a good percentage of NYC patients are getting HCQ at the onset of symptoms now. Cuomo wants more of it, because it "appears to be working". Oklahoma is giv…

The fact that you can buy the drug over the counter doesn't mean it's universally safe. The people being hospitalized here are already doing poorly so exposing them to additional risk is not something you should just do on a whim. As the linked post mentions, there are clear signs of potential risks associated with the use of HCQ. I hope for the patients being dosed with it now that it both works and is safe, but it'…

> A healthy person taking a reasonable dose as a malaria countermeasure is not the same as a person on a ventilator in the ICU.

Well I don’t think a person on a ventilator is in any position to self medicate, a doctor who presumably knows what they’re doing would be the one to direct the course of treatment. What’s the problem with that? There’s literally no “established” treatment for Covid 19 other than “hope we can keep you alive long enough for your immune system to beat it”, so under a doctor’s care I really don’t think there’s a lot of downside to trying to establish the efficacy of certain drugs in lieu of a long trial process.

Re: Hydroxychloroquine Update for April 6

#50
post #45
post #3

Counterpoint: http://www.leparisien.fr/societe/sante/chloroquine-ne-perdon... You can do double blind studies until your patients are literally blue in the face, or you can try what works now. That is literally the choice at the moment. According to Peter Navarro, a good percentage of NYC patients are getting HCQ at the onset of symptoms now. Cuomo wants more of it, because it "appears to be working". Oklahoma is giv…

Opting to listen to Navarro over Fauci is a very odd choice. Look, I get that certain discussions on this damn site resist dragging politics into it all, but this is pretty important: Navarro has nowhere near the qualifications that Fauci does and there is no reason to listen to him on this. You're contributing to a larger problem with misinformation at a time when it's not needed. Listen to the medical professional,…

I think he's just relying on Navarro's reporting that HCQ is being used in NYC, which, it clearly is; it looks like it's being tried all over the place. You can probably safely quote administration officials on something that simple. If he quoted Navarro saying HCQ was working, that would be problematic, especially because it doesn't seem to be working.
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