Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Lyme disease bacteria eradicated by new drug in early tests

scopeblog.stanford.edu

Post reply on HN
Print view View original

31–40 of 186 posts

Re: Lyme disease bacteria eradicated by new drug in early tests

#31

Post by Alex3917 »

PragmaticPulp wrote: post #28
Alex3917 wrote: post #25

Earlier quoted context omitted.

https://www.cdc.gov/ticks/tickbornediseases/tick-bite-prophy...

> https://www.cdc.gov/ticks/tickbornediseases/tick-bite-prophy... Please read the study and the CDC web page you're linking to. They don't support your point. From the CDC link you provided: > Doxycycline (100 mg orally BID X 14 days) is generally recommended for prophylaxis in adults. From the study you linked to above: > A single 200-mg dose of doxycycline given within 72 hours The CDC recommends a 14-day course of…

You're reading the prophylaxis guide for Tularemia, not Lyme. The section on lyme says:

"In areas that are highly endemic for Lyme disease, a single prophylactic dose of doxycycline (200 mg for adults or 4.4 mg/kg for children of any age weighing less than 45 kg) may be used to reduce the risk of acquiring Lyme disease after the bite of a high risk tick bite."

You can also see their guidelines for doctors here:

https://www.cdc.gov/lyme/resources/FS-Guidance-for-Clinician...

Re: Lyme disease bacteria eradicated by new drug in early tests

#32

Post by foobarian »

PragmaticPulp wrote: post #2

Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…

Out of curiosity how come you have such detailed familiarity with the topic? Sorry if may be a sensitive question but it seems a relatively obscure thing to randomly get into. And to be sure I really appreciate your posts.

Re: Lyme disease bacteria eradicated by new drug in early tests

#33

Post by vimy »

PragmaticPulp wrote: post #2

Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease.

>RESULTS: Motile spirochetes identified histopathologically as Borrelia were detected in culture specimens, and these spirochetes were genetically identified as Borreliaburgdorferi by three distinct polymerase chain reaction (PCR)-based approaches. Spirochetes identified as Borrelia burgdorferi were cultured from the blood of seven subjects, from the genital secretions of ten subjects, and from a skin lesion of one subject. Cultures from control subjects without Lyme disease were negative for Borrelia using these methods https://www.ncbi.nlm.nih.gov/pubmed/29662016

The CDC is wrong and negligent about persistent Lyme. Just like they are about the masks for covid-19.

This is just one study demonstrating spirochetes surviving. I'm not gonna bother digging up the others, honestly not worth my time to try and convince one random person.

Look up disulfiram and it's effects on Lyme patients. It's another drug discovered in the same way as this one. Miraculous.

Re: Lyme disease bacteria eradicated by new drug in early tests

#34

Post by megous »

mrfusion wrote: post #17
megous wrote: post #12

Earlier quoted context omitted.

"Antibodies normally persist in the blood for months or even years after the infection is gone; therefore, the test cannot be used to determine cure." https://www.cdc.gov/lyme/diagnosistesting/index.html

Sorry I meant IgM not IgG.

The page says that: "Positive IgM results should be disregarded if the patient has been ill for more than 30 days."

The reason may be this:

https://www.sciencedirect.com/science/article/pii/S1198743X1...

Re: Lyme disease bacteria eradicated by new drug in early tests

#35

Post by wolco »

PragmaticPulp wrote: post #13
James_Henry wrote: post #11

Earlier quoted context omitted.

>> A recent study in humans demonstrated that B. burgdorferi DNA was identified in PTDLS patient by xenodiagnosis but unable to culture viable spirochete17. In about 85% of Lyme arthritis patients, B. burgdorferi DNA was detected in synovial fluid by polymerase chain reaction (PCR) testing The previous sentence is also important: >Many research studies has [sic] shown that B. burgdorferi establishes persistent infect…

I'll review the citations in this study once again, but the evidence for lingering spirochetes in humans is always thin. Much of it relies on indirect testing that is difficult to replicate or prone to laboratory errors. I'd love to be completely wrong and for this to be a game-changing solution, but after years of following this research I'm suspicious of the idea that persistent yet mysteriously undetectable (in hu…

The idea of lingering unwanted resistant bacteria not being killed by antibiotics have been shown true with other spore type bacteria. I don't have the background in this specific bacteria, why do you believe it would be so different?

Re: Lyme disease bacteria eradicated by new drug in early tests

#36

Post by hinkley »

PragmaticPulp wrote: post #2

Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…

Lyme disease talk just makes me think of Nicholas Zakas and then I get bummed out.

I know there's a guy, or maybe he represents a group of researchers, who thinks that Chronic Fatigue Syndrome is caused by inflammation in the brain, either due to some undetectable infection, or just a misfiring that is a lingering effect of some other insult (sounds to me like a histamine response aka allergy).

If your body thought you had the flu but you didn't, you'd be knocked on your ass not unlike many people with CFS or Lyme. And if it never stopped you'd be in pretty bad shape a year in.

So. Are we treating microbes that don't culture in a petri dish, or are we solving an autoimmune response gone whacky? You could really ask the same question about Crohn's or IBS.

I recall years ago reading a long story about a consultant who was called in to figure out why this black soot was all over a neighborhood around a brewery. The brewery said it was diesel exhaust. But why only this neighborhood? He heard of a similar problem is some town in the UK. But Petri dish after Petri dish cultured nothing that could explain the black soot. Ergo, it's not microbial.

Our intrepid consultant pours a small amount of distilled spirits onto a sample dish, and gets a bunch of black shit. The 'soot' was feeding off the Angel's Share (evaporative losses from the brewery), and would barely grow without it. Vigorous growth in vivo, negligible growth in vitro.

We've come up with a cure or treatment for so many microbes that we can detect, but how do we know we're detecting them all? People die of cancer not because cancer is getting worse (well, pollution notwithstanding) but because Cancer is patient. There's a lot of space in the middle for new vectors to slip in.

Re: Lyme disease bacteria eradicated by new drug in early tests

#37

Post by shmageggy »

foobarian wrote: post #32
PragmaticPulp wrote: post #2

Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…

Out of curiosity how come you have such detailed familiarity with the topic? Sorry if may be a sensitive question but it seems a relatively obscure thing to randomly get into. And to be sure I really appreciate your posts.

Hundreds of thousands of people have been diagnosed with Lyme, so probably millions know someone who has. There are posters about ticks at nearly every trailhead I've visited in the northeast US in the past five years. It's not obscure.

Re: Lyme disease bacteria eradicated by new drug in early tests

#39

Post by Ericson2314 »

PragmaticPulp wrote: post #2

Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…

Not to get in this heavily politicized fray, but PTDLS sure sounds easiest to explain as permanent damage after the disease. I mean, we already know nerves heal poorly. Why don't I hear more about this hypothesis?
Post reply on HN