21–30 of 186 posts
Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…
As someone who is a very active camper (pre-zombie-apocalypses summers) a human vaccination would be wonderful. When our kid was bitten, she had the same textbook bulls eye pattern so it was easy to see a clue. They use to have one, but it was pulled off the market.
Yes definitely agree. With deer pop growth and climate change the ticks are found in most places now. It’d be nice to know that if bitten they’d be more of a nuisance than a threat to health.
Earlier quoted context omitted.
I don't have any knowledge beyond what's in this article, but it appears that there is some evidence of Lyme bacteria surviving antibiotics, and the reason why this can occur: "According to the recent study, azlocillin shows promise because it appears to be able to kill the two morphological forms of the Lyme bacteria -- the actively replicating spiral forms and the semi-dormant round-body forms. Azlocillin also appe…
Yes, but note that they also admit that we only have some indirect suggestions that persistent infection is the cause of PTLDS symptoms: > Many researchers believe that doxycyline's inability to clear the persisters may account for the ongoing symptoms of some Lyme sufferers "Many researchers believe" is not the language you use when you have concrete evidence supporting the claim. To date, no one has been able to cu…
Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine): > Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne il…
> no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics This is true, but what I think most people don't realize is that the evidence that antibiotics kill the bacteria in the first place is also extremely dubious. If you read the main paper, it literally boils down to "people who take antibiotics are less likely to get a rash."[1] [1] https://www.nejm.org/doi/full/10.1056/nejm20…
Lyme disease treatment protocols are shown here: https://www.cdc.gov/lyme/treatment/index.html
Doxycycline is generally used for 14-21 days, twice daily, not a one-time dose as used in your linked study.
Even the linked study shows that Doxycycline acts on B. burgdorferi, even in the difficult stationary phase. Scroll down to Figure 6: https://www.nature.com/articles/s41598-020-59600-4 . Obviously Azlocillin is superior in this in vitro study, hence the news. But it still shows that Doxycycline is active against the bacteria. It's too bad that the authors didn't continue the test long enough to see Doxycycline either reach zero (presumably) or level off. Seems like a crucial piece of data that they strangely neglected to measure.
Earlier quoted context omitted.
> no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics This is true, but what I think most people don't realize is that the evidence that antibiotics kill the bacteria in the first place is also extremely dubious. If you read the main paper, it literally boils down to "people who take antibiotics are less likely to get a rash."[1] [1] https://www.nejm.org/doi/full/10.1056/nejm20…
You linked to a study of single-dose Doxycycline as potential prophylaxis. That's not how Lyme disease is treated. Lyme disease treatment protocols are shown here: https://www.cdc.gov/lyme/treatment/index.html Doxycycline is generally used for 14-21 days, twice daily, not a one-time dose as used in your linked study. Even the linked study shows that Doxycycline acts on B. burgdorferi, even in the difficult stationary…
As someone who is a very active camper (pre-zombie-apocalypses summers) a human vaccination would be wonderful. When our kid was bitten, she had the same textbook bulls eye pattern so it was easy to see a clue. They use to have one, but it was pulled off the market.
They're working on the new one: https://www.newsweek.com/lyme-disease-vaccine-valneva-fda-ap...
[1] https://valneva.com/wp-content/uploads/2019/06/2018_12_17_VL...
Earlier quoted context omitted.
Yes, but note that they also admit that we only have some indirect suggestions that persistent infection is the cause of PTLDS symptoms: > Many researchers believe that doxycyline's inability to clear the persisters may account for the ongoing symptoms of some Lyme sufferers "Many researchers believe" is not the language you use when you have concrete evidence supporting the claim. To date, no one has been able to cu…
Your evidence bar may be unrealistically high here—Lyme has never been successfully cultured in any context (unless you count xenodiagnosis as a form of culturing).
Not true. Not sure where you are reading that.
Lyme is difficult to culture, but it can be cultured: Scroll down to the "Culture" section: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441761/
Regardless, my bar for evidence would be human trials in PTLDS patients with Azlocillin. Given that Azlocillin is already FDA approved and the researchers initially started studying it in 2016, I'm surprised no one has tried it yet.
Earlier quoted context omitted.
You linked to a study of single-dose Doxycycline as potential prophylaxis. That's not how Lyme disease is treated. Lyme disease treatment protocols are shown here: https://www.cdc.gov/lyme/treatment/index.html Doxycycline is generally used for 14-21 days, twice daily, not a one-time dose as used in your linked study. Even the linked study shows that Doxycycline acts on B. burgdorferi, even in the difficult stationary…
https://www.cdc.gov/ticks/tickbornediseases/tick-bite-prophy...
Please read the study and the CDC web page you're linking to. They don't support your point.
From the CDC link you provided:
> Doxycycline (100 mg orally BID X 14 days) is generally recommended for prophylaxis in adults.
From the study you linked to above:
> A single 200-mg dose of doxycycline given within 72 hours
The CDC recommends a 14-day course of twice-daily dosing (BID = twice daily). It has no relationship to the single-dose NJEM study you linked to above.
Great news! Let’s hope the FDA doesn’t hold this up for years.
Let's hope the FDA does its job of ensuring it is safe and actually works as its proponents say. I'd rather they not give it 737 MAX style review.
Earlier quoted context omitted.
https://www.cdc.gov/ticks/tickbornediseases/tick-bite-prophy...
> https://www.cdc.gov/ticks/tickbornediseases/tick-bite-prophy... Please read the study and the CDC web page you're linking to. They don't support your point. From the CDC link you provided: > Doxycycline (100 mg orally BID X 14 days) is generally recommended for prophylaxis in adults. From the study you linked to above: > A single 200-mg dose of doxycycline given within 72 hours The CDC recommends a 14-day course of…