Live data from Hacker News

Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

medrxiv.org

11–20 of 123 posts

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#12
Seems relevant: https://twitter.com/SquawkCNBC/status/1245669685267439616

Not sure they've been doing proper studies and such because they're so slammed, but it seems they've been trying it in Italy and... maybe it helps some, but doesn't seem like it works miracles.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#13
post #11

I wish the current U.S. administration hadn't tried to turn this into a partisan issue.

It absolutely did not.

The press did.

The mainstream US media has become a one-sided partisan cheerleading squad for the Democrats, and most Americans are sick of it. We'll see how that works out in November.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#14
post #12

Seems relevant: https://twitter.com/SquawkCNBC/status/1245669685267439616 Not sure they've been doing proper studies and such because they're so slammed, but it seems they've been trying it in Italy and... maybe it helps some, but doesn't seem like it works miracles.

In combination with antibiotics and (it seems) zinc it looks quite effective.

A doctor in NY has treated with that combination and is up to almost 700 COVID-19 patients without one dying _or needing a ventilator_.

Some relevant quotes:

>Dr. Zelenko said the whole treatment costs only $20 over a period of 5 days with 100% success. He defines success as “Not to die.” Dr. Zelenko first posted his Facebook video message last week calling on President Trump to “advise the country that they should be taking this medication.”

>There are many other success stories about hydroxychloroquine across the country. Last week, Dr. William Grace, an oncologist at Lenox Hill Hospital in New York City, said they’ve not had a single death in their hospital because of hydroxychloroquine. “Thanks to hydroxychloroquine, we have not had a death in our hospital,’ Dr. Grace said.

From:

https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-...

When people are dying in large numbers, sometimes "anecdotal evidence" (especially with large samples) is plenty.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#15
I know someone with Lupus, as I'm sure many people do. This is really good news for most everyone right now. But for people who need these types of drugs to fight Lupus (and I'd assume many other diseases) this is really bittersweet because they can either not get it at all now, or only get a very small amount. It's good to see this is going to help people with Covid-19, I really hope the drug makers can get this production ramped up fast so others that need these drugs can get what they need again.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#16
post #11

I wish the current U.S. administration hadn't tried to turn this into a partisan issue.

Face it, HCQ is an old and cheap drug that doesn't fit Big Pharma profit visions.

Its much more enticing for Big Pharma to sell new patented solutions, so they will pay their PR mouthpieces (MSM) to "be cautious" of anything that doesn't achieve that end goal.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#17
post #5

“ Significance: Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia.”

So hate to ask this, can you explain this for non-medical spectators? Specifically what TTCR and is "absorption of pneumonia" a good thing (e.g. the body has absorbed the pneumonia and therefore it has gone away) or a bad thing (e.g. the body has absorbed the pneumonia and therefore has "collected" more)? From Paper: TTCR: Time to clinical recovery

In pneumonia, areas of the lungs fill with fluid. This prevents the area from filling with air, which therefore prevents the exchange of CO2 and O2 between the blood and air.

I will assume that 'absorption' in this sense refers to the fluid. It's a good thing when this happens, because that that area of the lung can be accessed by air again.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#18
post #5

“ Significance: Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia.”

So hate to ask this, can you explain this for non-medical spectators? Specifically what TTCR and is "absorption of pneumonia" a good thing (e.g. the body has absorbed the pneumonia and therefore it has gone away) or a bad thing (e.g. the body has absorbed the pneumonia and therefore has "collected" more)? From Paper: TTCR: Time to clinical recovery

I have a feeling that this is a mistranslation, not jargon. Other similar usage of "absorption" that I can find was also written by Chinese researchers.

edit: got downvoted, so adding link to only other "absorption of pneumonia" use that I could find: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344839/

edit2: I could also find some usage of "absorption of inflammation", again also all Chinese researchers.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#19
Based on this and all the other anecdotal studies plus all the people treated with it for other ailments, it seems fairly certain that at a minimum this treatment is not causing more harm. Given that plus all the indications that it seems to help to some degree, we should be pursuing production scale of these drugs aggressively.

It is very unfortunate that the media politicized this treatment in such a way that now everyone who dislikes Trump carries an initial bias against it.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#20

The sample size is 62 and the mortality rates are between 0% and 7% depending primarily on age and co-morbidities. I don't think we can draw any meaningful conclusions from this other than what we already know: seems worth looking into HCQ more.

How does the 2 cases of collateral effects compare to the normal consequences of the drug? It is very likely that we can draw conclusions about those.
Post reply on HN