Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

erikstarck wrote: post #3

“ Significance: Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia.”

So hate to ask this, can you explain this for non-medical spectators? Specifically what TTCR and is "absorption of pneumonia" a good thing (e.g. the body has absorbed the pneumonia and therefore it has gone away) or a bad thing (e.g. the body has absorbed the pneumonia and therefore has "collected" more)?

From Paper:

TTCR: Time to clinical recovery

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#6

Post by arcticbull » Thu, Apr 02, 2020, 2:20 PM UTC

The sample size is 62 and the mortality rates are between 0% and 7% depending primarily on age and co-morbidities. I don't think we can draw any meaningful conclusions from this other than what we already know: seems worth looking into HCQ more.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#7

Post by idclip » Thu, Apr 02, 2020, 2:22 PM UTC

coding123 wrote: post #2

So it works?

It sorta works. Its not a cure, but it seems to help.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#8

Post by zimpenfish » Thu, Apr 02, 2020, 2:22 PM UTC

View from a pharma-focused organic chemist:

https://blogs.sciencemag.org/pipeline/archives/2020/03/31/co...

TL;DR: better than the French paper but that's a low, low bar

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#9

Post by arcticbull » Thu, Apr 02, 2020, 2:22 PM UTC

coding123 wrote: post #2

So it works?

Too small a sample size to say.

Re: Efficacy of hydroxychloroquine in patients with Covid-19: a randomized trial

#10

Post by tgv » Thu, Apr 02, 2020, 2:23 PM UTC

coding123 wrote: post #2

So it works?

It looks as if this was better executed than the earlier, criticized study, but with just 2x32 patients, we'll probably have to wait for replication.

One thing that certainly should be cleared up is the age effect: they report "No difference in the age ... distribution ", but that's not enough.