Earlier quoted context omitted.
In my experience I’ve seen even technical users (Who were used to windows) struggle with the idea of dragging an .app from an open disk image to the Applications folder. They would end up running the app from the disk image and then getting confused when it disappears after restart.
This system worked so much better when the Applications folder was placed in the Dock by default, and everyone used that folder launch applications (which weren't common enough to keep in the Dock directly). It was actually a really beautiful synergy—you install applications by copying them to a folder, and launch them from that folder. Same way you'd acquire and open files. Lovely. Then Apple ruined it in Lion with…
though preferences files were a bit of a mess.
I vaguely remember if early Macintosh System versions you would be prompted to insert the disk (with the correct disk name in the message) if you tried to open a file belonging to an application which was on an ejected disk.