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First hydroxychloroquine randomized controlled trial: results disappointing
31–40 of 99 posts
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#32For people that didn't read: it's "disappointing" because both the control and study groups largely tested negative (93% and 87% respectively). That 87% figure sounds worse than the control but it actually is better than in the French study. What happened in essence is that almost all cases were mild so the patients almost all got better after a while, with or without medication. This doesn't mean HCQ is ineffective,…
It's disappointing because it's no better than placebo.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#33This is evidence; it isn't great but it also isn't conclusive. We'll need to wait longer for something a little more decisive. A twitter link is also unhelpful because we only get a blurry abstract to go off. The happy dream is maybe hydroxychloroquine has prophylactic tendencies since it is something people can take long term to be at a substantially lower risk vs catching COVID. The abstract doesn't really show muc…
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Re: First hydroxychloroquine randomized controlled trial: results disappointing
#34This is evidence; it isn't great but it also isn't conclusive. We'll need to wait longer for something a little more decisive. A twitter link is also unhelpful because we only get a blurry abstract to go off. The happy dream is maybe hydroxychloroquine has prophylactic tendencies since it is something people can take long term to be at a substantially lower risk vs catching COVID. The abstract doesn't really show muc…
Covid-19: India Recommends Hydroxychloroquine As Prophylaxis For Healthcare Providers, Patient Family Members
https://swarajyamag.com/insta/covid-19-india-recommends-hydr...
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#35For people that didn't read: it's "disappointing" because both the control and study groups largely tested negative (93% and 87% respectively). That 87% figure sounds worse than the control but it actually is better than in the French study. What happened in essence is that almost all cases were mild so the patients almost all got better after a while, with or without medication. This doesn't mean HCQ is ineffective,…
It's disappointing because it's no better than placebo.
In this case (as with many others) placebo is pretty effective, but also, these folks didn't get sick enough to need it, as with the overwhelming majority of young and healthy people. Another, broader study is required. I'm sure we'll find out more soon -- this reads like a mulligan though.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#36For people that didn't read: it's "disappointing" because both the control and study groups largely tested negative (93% and 87% respectively). That 87% figure sounds worse than the control but it actually is better than in the French study. What happened in essence is that almost all cases were mild so the patients almost all got better after a while, with or without medication. This doesn't mean HCQ is ineffective,…
It's disappointing because it's no better than placebo.
You mean "not worse". If almost everyone got cured there's hardly any leeway to be even better.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#37Thank goodness that we are actually getting some RCT results. There has been a huge confirmation bias towards any positive results for chloroquine, no matter how specious or flawed the underlying science was. Everybody wants this to work because the drug is well-tested on humans, cheap, and broadly available. It would be a panacea, a miracle drug. My concern is that the desire for this drug to be effective has clouded people's judgment (even seasoned researchers) and led to bad science.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#38Re: First hydroxychloroquine randomized controlled trial: results disappointing
#39I am sorry, but isn't the mechanism of action that hydroxychloroquine is simply a zinc ionophore, i.e. you need enough free zinc in the blood for this to work? I read doctors suggesting using hydroxychloroquine along with 50mg of ionic zinc.
Like Reelin said, it's effectiveness may be related to it's ability to modulate immune activity by affecting pH. https://www.ncbi.nlm.nih.gov/pubmed/27927040 Course, that'll only work if the symptoms are being caused by an overactive immune system and it's able to mediate that immune response in time.
> Course, that'll only work if the symptoms are being caused by an overactive immune system and it's able to mediate that immune response in time.
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome [1]. HCQ is known to moderate this reaction.
[1] https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#40Earlier quoted context omitted.
Yeah, I'm following a bunch of scientists on Twitter and have been watching from the sidelines with awe and admiration. The contrast to the seeming hordes of dumbfucks could hardly be more remarkable; sometimes it's hard to keep in mind the same platform is host to both sets of people.
This Doctor in NY seems to have had great results so far https://www.thegatewaypundit.com/2020/03/stunning-ny-doctor-... This Doctor, Health Commissioner of NYC, Oxiris Barbot, seemed to take a lot of joy in proclaiming: Today our city is celebrating the #LunarNewYear parade in Chinatown, a beautiful cultural tradition with a rich history in our city. I want to remind everyone to enjoy the parade and not change any p…
> This Doctor in NY seems to have had great results so far https://www.thegatewaypundit.com/2020/03/stunning-ny-doctor-....
Let's stick with legitimate news sources.
Either way no data is provided there, but the case fatality rate for folks under 10 is 0% and under 29 is between 0.1% and 0%. If this hypothetical doctor even exists, it wouldn't be hard to pick 350 people, give them some HCQ and Azithromycin and have 100% of them recover -- as they would have even if they hadn't received anything. That's more or less what this study shows.
In fact, as the fatality rate for under-29s is 0.1%, you have a 70% ((1-0.001)^12) chance that any randomly selected 350 of them will recover.