First hydroxychloroquine randomized controlled trial: results disappointing
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Re: First hydroxychloroquine randomized controlled trial: results disappointing
#2didnt find a link to the abstract, seems the results are just being published
link to the trial on clinicaltrials.gov is here: https://clinicaltrials.gov/ct2/show/NCT04261517
patients in both tx and control arm fared better than in the french study from earlier this week, suggesting patients were healthier / lower risk at baseline
patients got slightly lower dose in this study (400 mg / day) vs the french study (600 mg / day)
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#3> That was a first run trial without the Zpak. The following trial with both showed 100% efficacy after 5-6 days.
Is that twitter reply accurate?
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#4Not unexpected. A week or two ago a Chinese treatment protocol made the rounds where hydroxychloroquine was suggested as an alternative to HIV protease inhibitors. Since we now know that ritonavir/lopinavir doesn't work well, one wouldn't expect hydroxychloroquine to do any better. If it had remarkable clinical effects it would be the first-line treatment.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#5> That was a first run trial without the Zpak. The following trial with both showed 100% efficacy after 5-6 days. Is that twitter reply accurate?
No, that trial has some glaring flaws. Several threads go into them way better than I could.
https://twitter.com/GaetanBurgio/status/1241201751916568576
https://twitter.com/MicrobiomDigest/status/12414295448478638...
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#6The reported dosage is less than half what the Chinese Government recommends (500mg x 2 (BID)). So it's possible that they didn't hit the effective dose. https://medium.com/@balajis/the-official-chinese-government-...
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#7didnt find a link to the abstract, seems the results are just being published link to the trial on clinicaltrials.gov is here: https://clinicaltrials.gov/ct2/show/NCT04261517 patients in both tx and control arm fared better than in the french study from earlier this week, suggesting patients were healthier / lower risk at baseline patients got slightly lower dose in this study (400 mg / day) vs the french study (600…
Kind of crazy these are not in the open. Especially when we are used to work in software.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#8didnt find a link to the abstract, seems the results are just being published link to the trial on clinicaltrials.gov is here: https://clinicaltrials.gov/ct2/show/NCT04261517 patients in both tx and control arm fared better than in the french study from earlier this week, suggesting patients were healthier / lower risk at baseline patients got slightly lower dose in this study (400 mg / day) vs the french study (600…
Kind of crazy these are not in the open. Especially when we are used to work in software.
It may be that they just presented an abstract and the manuscript has not yet been submitted for publication or peer reviewed
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#9didnt find a link to the abstract, seems the results are just being published link to the trial on clinicaltrials.gov is here: https://clinicaltrials.gov/ct2/show/NCT04261517 patients in both tx and control arm fared better than in the french study from earlier this week, suggesting patients were healthier / lower risk at baseline patients got slightly lower dose in this study (400 mg / day) vs the french study (600…
Someone on the Twitter thread linked to this, which seems to be not exactly the same document but contains very similar text in the abstract:
http://subject.med.wanfangdata.com.cn/UpLoad/Files/202003/43...
I think it helps if you can read Chinese, though Google Translate seems to do a pretty ok job on it.
Re: First hydroxychloroquine randomized controlled trial: results disappointing
#10Earlier quoted context omitted.
Kind of crazy these are not in the open. Especially when we are used to work in software.
It may be that they just presented an abstract and the manuscript has not yet been submitted for publication or peer reviewed
Well let's peer review this wikipedia-style. Not sure why academia is stuck in last century.